Charles Bowesman, O.B.E., B.A., M.D., F.R.C.S.E., F.A.C.S., D.T.M.&H., Editor. 1st edition, 1068 + viii pages, illustrated. Edinburgh and London, E. & S. Livingstone Ltd. (The Williams & Wilkins Co., Baltimore, exclusive U.S. agents), 1960. $22.50
The fluorescent-antibody responses were determined during the course of infection in nine Macaca mulatta monkeys infected with Plasmodium cynomolgi.
FA response increased initially in both sporozoite and blood-induced infections, reaching an initial peak titer that was often as high as, or higher than, that found after extended periods of parasitemia. There was a rapid decline in FA response in one case following the elimination of the infection by chemotherapy after a brief parasitemia. Similarly, splenectomy of two animals during the infection resulted in a rapid, but temporary, decline in FA response.
The FA response to the P. fieldi antigen was similar to the homologous response, suggesting the usefulness of this antigen as a substitute for homologous antigens in such studies.