Fluorescent-Antibody Studies on Simian Malaria

II. Development of Antibodies to Plasmodium Cynomolgi

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  • National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Primate Malaria, P. O. Box 190, Chamblee, Georgia 30005


The fluorescent-antibody responses were determined during the course of infection in nine Macaca mulatta monkeys infected with Plasmodium cynomolgi.

FA response increased initially in both sporozoite and blood-induced infections, reaching an initial peak titer that was often as high as, or higher than, that found after extended periods of parasitemia. There was a rapid decline in FA response in one case following the elimination of the infection by chemotherapy after a brief parasitemia. Similarly, splenectomy of two animals during the infection resulted in a rapid, but temporary, decline in FA response.

The FA response to the P. fieldi antigen was similar to the homologous response, suggesting the usefulness of this antigen as a substitute for homologous antigens in such studies.