by Richard R. Kudo, D. Sc., Professor of Zoology, the University of Illinois, Urbana, Illinois. Seven hundred seventy eight pages with 336 illustrations. Third edition, Charles C. Thomas, Springfield, Illinois, 1946
Tlacotalpan virus, a new Bunyamwera-group virus, was recovered from Mansonia titillans, and closely related, probably identical viruses were isolated from Anopheles albimanus, An. spp., and Aedes taeniorhynchus mosquitoes collected during July and August 1961 and 1963 at Tlacotalpan, Veracruz, on the tropical southeastern coast of Mexico. This virus killed suckling and weanling mice, and produced plaques in primary chicken or duck embryonic-cell cultures and CPE in HeLa and L but not primary hamster-kidney-cell cultures. Neutralization tests of plasmas or sera revealed antibodies in persons at Tlacotalpan, in cattle and pigs at several locations along the tropical southeastern coast in Veracruz and Tabasco, and in one cow from the tropical western central coast in Nayarit. Thus Tlacotalpan virus infected man and domestic animals, but its disease-producing potentialities remain to be assessed.
These investigations were performed by collaboration among persons from the above institutions, the Pan American Health Organization, and the Government of the United States of Mexico; they were supported in part by United States Public Health Service training grants No. 2E-188 and 5-T1-AI-231 from the National Institute of Allergy and Infectious Disease and in part by the Surgeon General, Department of the Army, under sponsorship of the Commission on Viral Infections of the Armed Forces Epidemiological Board.