By H. J. Bensted, W. Bulloch, L. Dudgeon, A. G. Gardner, E. D. W. Greig, D. Harvey, W. F. Harvey, T. J. Mackie, R. A. O'Brien, H. M. Perry, H. Scutze, P. Bruce White, W. J. Wilson. London, 1929. His Majesty's Stationery Office. Pp. 1–482
by A. Trevor Willis, M.D., B.S. (Melb.), Ph.D. (Leeds), M.C.Path., M.C.P.A., Reader in Microbiology, Monash University, formerly Lecturer in Bacteriology, University of Leeds. xiv + 234 pages, illustrated, second edition. Butterworth Inc., Washington. 1965. $8.50
CI-564, a 1:1 mixture of cycloguanil pamoate (CI-501) and 4,4′-diacetylaminodiphenyl sulfone (CI-556), was evaluated as a therapeutic agent against blood-induced infections of the Chesson strain of Plasmodium vivax. With a dose of 5 mg per kg of body weight given intramuscularly, cure was effected in each of two volunteers infected with the chlorguanide-sensitive strain. Clearance of patent parasitemia required 3 to 4 days. In two other volunteers infected with the chlorguanide-resistant strain, the clinical and parasitologic courses were modified, but parasitemia was not cleared after 14 and 28 days.
Present address: Department of Pharmacology, Louisiana State University School of Medicine, New Orleans, Louisiana.