V. Evaluation of Cross-Immunity against Type 1 Dengue Fever in Human Subjects Convalescent from Subclinical Natural Japanese Encephalitis Virus Infection and Vaccinated with 17D Strain Yellow Fever Vaccine
Mice infected with an average of less than three pairs of Schistosoma japonicum worms developed signs that closely resemble clinical Schistosomiasis japonica. By 8 weeks after exposure to 14 cercariae, the animals had esophageal varices, a 70% increase in liver weight, a 100% increase in portal pressure, and a 200% increase in spleen weight. The livers contained numerous schistosome eggs (frequently in aggregates of as many as 10) surrounded by severe granulomatous reactions. Total serum protein concentration rose 20%, albumin concentration fell 70%, beta globulin concentration rose 65% and gamma globulin concentration rose 200%.
Murine Schistosomiasis japonica appears to be a more severe disease than murine schistosomiasis mansoni.
Work carried out in partial fulfillment of the requirements for the M.D. degree, School of Medicine, Western Reserve University.