Studies on the Antimalarial Effects of Cycloguanil Pamoate (CI-501) in Man

Robin D. PowellArmy Medical Research Unit of the Department of Medicine, Division of the Biological Sciences, University of Chicago, Chicago, Illinois

Search for other papers by Robin D. Powell in
Current site
Google Scholar
PubMed
Close
,
Richard L. DeGowinArmy Medical Research Unit of the Department of Medicine, Division of the Biological Sciences, University of Chicago, Chicago, Illinois

Search for other papers by Richard L. DeGowin in
Current site
Google Scholar
PubMed
Close
, and
R. Bennett EppesArmy Medical Research Unit of the Department of Medicine, Division of the Biological Sciences, University of Chicago, Chicago, Illinois

Search for other papers by R. Bennett Eppes in
Current site
Google Scholar
PubMed
Close
Restricted access

Summary

Studies on the antimalarial effects of cycloguanil pamoate (CI-501) were conducted with healthy, adult, male volunteers. Investigations were carried out in a non-malarious area and under conditions precluding reinfection. Evidence obtained confirmed findings reported previously by other workers indicating that a single intramuscular dose of CI-501 can confer protection for months against patency of sporozoite-induced infections with the Chesson strain of Plasmodium vivax. CI-501 did not exert a similar long-lasting protective effect against sporozoite-induced infections with strains of chloroquine-resistant (and chlorguanide-resistant) P. falciparum from Southeast Asia.

Author Notes

Department of Medicine, University of Chicago.

Medical Corps, United States Army.

Save