edited by W. H. Taliaferro, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, and J. H. Humphrey, National Institute of Medical Research, London, England. Vol. 1, x + 423 pages, illustrated. New York, London, Academic Press. 1961. $12.00
V. Evaluation of Cross-Immunity against Type 1 Dengue Fever in Human Subjects Convalescent from Subclinical Natural Japanese Encephalitis Virus Infection and Vaccinated with 17D Strain Yellow Fever Vaccine
The test for passive cutaneous anaphylaxis (PCA) proved relatively simple and easy to perform. Within limits, the minimal amount of challenge Trichinella antigen was dependent on the amount of antibody used for sensitization. The optimal concentrations of Trichinella and Toxocara antigens to use in PCA tests with these experimental infections were determined. Studies with rabbit and guinea pig antisera indicate that antibodies involved in PCA reactions may differ from those involved in bentonite flocculation or hemagglutination tests. PCA reactions with heterologous antigens are common. The simplicity of the procedure is considered of distinct value and advantageous, but the amount of antigen required for a reaction and the possibility of cross-reactions are drawbacks.
Department of Microbiology, University of Missouri, Columbia, Missouri.