Effect of Frequency of Administration on Antimony Activity Against Schistosoma Mansoni in Mice

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  • U. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, Maryland 20014
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The trivalent antimony compounds stibophen and sodium dimercaptosuccinate were shown to be much more effective against adult Schistosoma mansoni worms in mice when administered in a series of small closely spaced injections than when the total dose was given in fewer injections over the same period of treatment. The beneficial effects of feeding a purified type of diet were also demonstrated.