Effect of Frequency of Administration on Antimony Activity Against Schistosoma Mansoni in Mice

William B. DeWittU. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, Maryland 20014

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The trivalent antimony compounds stibophen and sodium dimercaptosuccinate were shown to be much more effective against adult Schistosoma mansoni worms in mice when administered in a series of small closely spaced injections than when the total dose was given in fewer injections over the same period of treatment. The beneficial effects of feeding a purified type of diet were also demonstrated.