Epidemiology of Machupo Virus Infection

II. Ecological and Control Studies of Hemorrhagic Fever

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  • Middle America Research Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Balboa Heights, Canal Zone


The localities in Bolivia from which cases of hemorrhagic fever have been reported are farming communities with characteristic ecological features. The rodent, Calomys callosus, is an important reservoir host of the Machupo virus. An experimental program of disease control was successfully carried out in San Joaquín, Beni, Bolivia. Rodent control measures directed primarily against Calomys callosus populations in the houses of the village resulted in a prompt and dramatic cessation of human cases.