Chromium51 Red Cell Half-Life in Severe Iron Deficiency Anemia

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  • Medical and Biochemistry Department, U. S. Naval Medical Research Unit No. 3, Division of Nutrition and Department of Biochemistry, Vanderbilt University School of Medicine, Cairo, Egypt


The relationship between Cr51 red cell half-life, degree of iron deficiency anemia, and intestinal blood loss was studied in twenty-seven patients and the half-life found to be shortened in all patients with hemoglobin values under 6.5 g per 100 ml, irrespective of intestinal blood loss. Treatment of the anemia corrected the half-life. Sequestration of the iron-depleted red cells by the enlarged spleen was demonstrated in two severely anemic patients.