Alterations in Serum Proteins and 19S Antibody Production during the Course of Induced Malarial Infections in Man

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  • National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland


Increases in β2M macroglobulins have been detected by means of immunoelectrophoresis during the course of induced malarial infections in man. The increase in this serum globulin coincides closely with the appearance of antibodies to malaria as detected by fluorescent antibody studies. Evidence is presented that 19S β2M macroglobulin antibodies as well as 7S gamma globulin antibodies are formed during the course of primary malarial infections in human volunteers.

Author Notes

Laboratory of Immunology.

Laboratory of Germfree Animal Research.

Laboratory of Clinical Investigations.

Laboratory of Parasite Chemotherapy.