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Alterations in Serum Proteins and 19S Antibody Production during the Course of Induced Malarial Infections in Man
Donald C. Abele
Donald C. Abele
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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John E. Tobie
John E. Tobie
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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George J. Hill
George J. Hill
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Peter G. Contacos
Peter G. Contacos
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Charles B. Evans
Charles B. Evans
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Summary
Increases in Ī²2M macroglobulins have been detected by means of immunoelectrophoresis during the course of induced malarial infections in man. The increase in this serum globulin coincides closely with the appearance of antibodies to malaria as detected by fluorescent antibody studies. Evidence is presented that 19S Ī²2M macroglobulin antibodies as well as 7S gamma globulin antibodies are formed during the course of primary malarial infections in human volunteers.
Author Notes
Laboratory of Immunology.
Laboratory of Germfree Animal Research.
Laboratory of Clinical Investigations.
Laboratory of Parasite Chemotherapy.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 257 | 111 | 5 |
| Full Text Views | 4 | 0 | 0 |
| PDF Downloads | 1 | 0 | 0 |