Chagres Virus: A New Human Isolate from Panama

Pauline H. Peralta U. S. Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Tropical Virology, Middle America Research Unit, Bethesda, Maryland

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Alexis Shelokov U. S. Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Tropical Virology, Middle America Research Unit, Bethesda, Maryland

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Jacob A. Brody U. S. Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Tropical Virology, Middle America Research Unit, Bethesda, Maryland

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Summary

A virus new to Middle America, the Chagres virus, was isolated in Panama from the blood of a patient who was infected with the virus. It was found to be pathogenic for suckling and weanling mice and to be sensitive to sodium desoxycholate. A hemagglutinin was demonstrated which exhibited unusual characteristics under certain conditions. No relationship of this virus to 49 other arboviruses could be demonstrated by means of the complement-fixation test. The presence of neutralizing antibody in human sera from one Panamanian community was demonstrated.

Author Notes

Present address: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014.

Present address: Arctic Health Research Center, Anchorage, Alaska.

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