Laboratory Studies with Wild Rodents and Viruses Native to Trinidad

II. Studies with the Trinidad Caraparu-like Agent TRVL 34053-1

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  • University of the West Indies, Trinidad Regional Virus Laboratory, P. O. Box 164, Port of Spain, Trinidad, W. I.
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Trinidad virus TRVL 34053-1, belonging in group C and closely related to Caraparu virus, was shown to circulate in the blood of naturally and experimentally infected Oryzomys laticeps velutinus. All seven experimental animals circulated virus; the maximum virus level observed in their serum was 5.8 dex LD50 for adult mice inoculated intracerebrally with 0.03 ml.

Studies with 80 experimentally infected animals, 40 Oryzomys and 40 Zygodontomys b. brevicauda, showed that hemagglutination-inhibiting (HI), complement-fixing and neutralizing antibodies persist for at least 1 year after infection with 34053-1 virus. HI antibodies derived from experimentally infected mothers of these two species persisted for about 2 months after birth and neutralizing antibodies persisted for about 1 month longer.

Author Notes

With the technical assistance of Owen M. Olivier.