A Clinical Trial of Two Bephenium Hydroxynaphthoate Preparations Against Hookworm and Roundworm in West Pakistan

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Two preparations of bephenium hydroxynaphthoate were compared in the treatment of 140 persons with Ancylostoma duodenale and Ascaris lumbricoides infections. A single dose of 2.5 g (base) gave excellent results against both parasites.

Against A. duodenale a single dose of 1.25 g (base) as pellets gave a high cure rate, while 0.625 g (base) produced considerable reductions in egg counts.

Results against A. lumbricoides indicated that the minimum effective single dose lay between 1.25 g and 1.75 g (base).

Both preparations were easy to administer and well tolerated.

Author Notes

The Institute of Hygiene and Preventive Medicine, Birdwood Road, Lahore.

The Wellcome Laboratories of Tropical Medicine, Euston Road, London.