Active Immunization Against Malaria

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Active immunization against malaria is a subject notable for the attention it has not received during the last decade or decade and a half. Early evaluation of the potential of active immunization in man yielded either negative or inconclusive results. During and immediately after World War II, other investigative approaches aimed at combating malaria seemed more promising and were pursued vigorously. Active immunization was relegated a position far in the background.

The introduction of DDT and the development of other effective residual insecticides made possible a new approach to global control of malaria. A new foundation was provided for massive efforts to eradicate malaria by interruption of transmission through the definitive host, the mosquito. In addition, persistent, methodical, and industrious efforts to develop effective chemotherapeutic agents led to some brilliant achievements. Impressive successes that resulted in both the insecticidal and chemotherapeutic fronts took wind out of the sails of malaria research.

Author Notes

Army Medical Research Project of the Department of Medicine, Division of the Biological Sciences, University of Chicago, Chicago, Illinois.