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Clinical Trials of Stilbazium Iodide (Monopar®) in the Treatment of Trichuris and Ascaris Infections
Wen-Hsien Huang
Wen-Hsien Huang
College of Medicine, National Taiwan University, College of Physicians and Surgeons, Columbia University, Taipei, Taiwan
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Harold W. Brown
Harold W. Brown
College of Medicine, National Taiwan University, College of Physicians and Surgeons, Columbia University, Taipei, Taiwan
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Summary
Stilbazium iodide (Monopar®) in doses of 8.8 mg/kg twice daily for 3 days was effective against Trichuris trichiura and Ascaris lumbricoides. In a group of children given this dosage, 9 of 23 with Trichuris, and 13 of 18 with Ascaris infections were cured. In the above dosage the drug showed only moderate efficacy against Ancylostoma duodenale and Necator americanus. For Ascaris infection, 10 mg/kg given once daily for 3 days was as effective as was the 8.8 mg/kg twice daily schedule. Vomiting was common but no other side-effects were noted.
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