Fluorescent Antibody Studies in Human Malaria

I. Development of Antibodies to Plasmodium Malariae

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  • Department of Health, Education, and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Cytology, P. O. Box 195, Chamblee, Georgia
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Using the indirect fluorescent antibody method, the production and persistence of specific antibody was demonstrated in three patients inoculated with blood parasites of Plasmodium malariae. In one case a relatively high antibody level was maintained in association with persistent asymptomatic parasitemia, while in one of the others, termination of the infection resulted in a delayed, slow decline in antibody titer to a persistent lower level. Higher antibody titer appeared to be associated with the primary infection characterized by reduced parasitemia and febrile attack.

Author Notes

Present address: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland.