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Studies on Trachoma
III. Comparison of Virus Infectivity for Man and Chick Embryos
Samuel D. Bell Jr.
Samuel D. Bell Jr.
Department of Microbiology, Harvard University, School of Public Health, Boston, Massachusetts
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Edward S. Murray
Edward S. Murray
Department of Microbiology, Harvard University, School of Public Health, Boston, Massachusetts
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Thomas J. Carroll
Thomas J. Carroll
Department of Microbiology, Harvard University, School of Public Health, Boston, Massachusetts
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John C. Snyder
John C. Snyder
Department of Microbiology, Harvard University, School of Public Health, Boston, Massachusetts
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Summary
Three experiments on six volunteers challenged with aliquots of the same pool of trachoma virus (Saudi Arabian strain 2) are described. Under the conditions of the experiments the endpoints for infectivity for chick embryos and the human eye closely approximated each other. Incubation of chick embryos infected with trachoma virus at 34.0° to 35.0°C with constant, high relative humidity increased the accuracy of titrations and raised the infectious endpoint several fold. The effects of formalin-killed vaccines on individuals vaccinated 3 years previously and boostered just prior to challenge were inconclusive.
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