Kidney Biopsy in Human Leptospirosis

D. Penna Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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T. de Brito Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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A. Aguiar Pupo Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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M. Marcondes Machado Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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P. A. Ayroza Galvão Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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S. Soares de Almeida Medical School of São Paulo, Hospital das Clinicas, Institute of Tropical Medicine, and Hospital Emilio Ribas, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1963.12.896
Volume/Issue:
Volume 12: Issue 6
Page(s):
896–901
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Summary

Percutaneous kidney biopsies were performed on thirteen patients with leptospirosis. The method is considered to be safe and in some cases useful for research and diagnostic purposes. Since the specific agglutination test may not become positive for a relatively long time, the biopsy can provide confirmatory evidence in doubtful cases.

No marked difference was found between the histopathological findings of autopsy and at biopsy except that the lesions in biopsy material were less severe and more focal. A close similarity was noted between acute tubular necrosis and the interstitial nephritis seen in leptospirosis, the peculiarities in the latter being determined by the recurrent character of this entity. The functional impairment can possible also be explained by the observation that mitochondria of tubule cells were markedly depleted in the regenerating epithelium.

Author Notes

Copyright:
Copyright © 1963, By The American Society of Tropical Medicine and Hygiene 1963
Published Online:
Nov 1963
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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