Comparison of the Effect of Cortisone and of Trichinella Spiralis Infection on Injury to Rats by Encephalomyocarditis Virus Infection

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  • Department of Health, Education, and Welfare, U. S. Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda 14, Maryland
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Rats treated with large doses of cortisone acetate were less susceptible to paralysis following challenge with encephalomyocarditis (EMC) virus than were rats previously infected with Trichinella spiralis. Trichinella infection did not affect the weight of spleen, thymus or adrenal glands and is therefore presumed to have had little influence on endogenous corticosteroid secretion.

Author Notes

With the technical assistance of Ned M. Etherington.