Authors:
, , , , , , , , , , , , , , , , , and
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Haseeb AN, el-Shazly AM, Arafa MA, Morsy AT, 2002. A review on fascioliasis in Egypt. J Egypt Soc Parasitol 32: 317–354.
-
2.
Sohn BW, Kang GS, Han TH, 1992. Studies on the optimal time for therapy of Fasciola spp. infected cattle in central area of Korea. Korean J Vet Serv 15: 1–6.
-
3.
Sohn BH, 2000. Current status and plan of the fascioliasis in cattle. J Korean Vet Med Assoc 39: 806–818.
-
4.
Kim YH, Kang KJ, Kwon JH, 2005. Four cases of hepatic fascioliasis mimicking cholangiocarcinoma. Korean J Hepatol 11: 169–175.
-
5.
World Health Organization, 2007. Report of the WHO Informal Meeting on use of triclabendazole in fascioliasis control, WHO headquarters, Geneva, Switzerland, 17–18 October 2006. Geneva, Switzerland: WHO.
-
6.
Apt W, Aguilera X, Vega F, Miranda C, Zulantay I, Perez C, Gabor M, Apt P, 1995. Treatment of human chronic fascioliasis with triclabendazole: Drug efficacy and serologic response. Am J Trop Med Hyg 52: 532–535.
-
7.
Choi S, Park S, Hong S, Shin H, Jung BK, Kim MJ, 2022. Green vegetable juice as a potential source of human fascioliasis in Korea. One Health 15: 100441.
-
8.
Jin Y, Kim EM, Choi MH, Oh MD, Hong ST, 2017. Significance of serology by multi-antigen ELISA for tissue helminthiases in Korea. J Korean Med Sci 32: 1118–1123.
-
9.
Venkatesh SK et al.; IPSCSG, 2022. Reporting standards for primary sclerosing cholangitis using MRI and MR cholangiopancreatography: Guidelines from MR Working Group of the International Primary Sclerosing Cholangitis Study Group. Eur Radiol 32: 923–937.
-
10.
Marcos LA, Terashima A, Gotuzzo E, 2008. Update on hepatobiliary flukes: Fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis 21: 523–530.
-
11.
Parkinson M, O’Neill SM, Dalton JP, 2007. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect 135: 669–674.
-
12.
Kaya M, Bestas R, Cetin S, 2011. Clinical presentation and management of Fasciola hepatica infection: Single-center experience. World J Gastroenterol 17: 4899–4904.
-
13.
Aksoy DY, Kerimoglu U, Oto A, Erguven S, Arslan S, Unal S, Batman F, Bayraktar Y, 2005. Infection with Fasciola hepatica. Clin Microbiol Infect 11: 859–861.
-
14.
Mas-Coma S, Bargues MD, Valero MA, 2014. Diagnosis of human fascioliasis by stool and blood techniques: Update for the present global scenario. Parasitology 141: 1918–1946.
-
15.
Schiappacasse RH, Mohammadi D, Christie AJ, 1985. Successful treatment of severe infection with Fasciola hepatica with praziquantel. J Infect Dis 152: 1339–1340.
-
16.
Dusak A, Onur MR, Cicek M, Firat U, Ren T, Dogra VS, 2012. Radiological imaging features of Fasciola hepatica infection – A pictorial review. J Clin Imaging Sci 2: 2.
-
17.
Richter J, Freise S, Mull R, Millán JC, 1999. Fascioliasis: Sonographic abnormalities of the biliary tract and evolution after treatment with triclabendazole. Trop Med Int Health 4: 774–781.
-
18.
Kang BK, Jung BK, Lee YS, Hwang IK, Lim H, Cho J, Hwang JH, Chai JY, 2014. A case of Fasciola hepatica infection mimicking cholangiocarcinoma and ITS-1 sequencing of the worm. Korean J Parasitol 52: 193–196.
-
19.
Hillyer GV, Serrano AE, 1983. The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani. Am J Trop Med Hyg 32: 350–358.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1428 | 1428 | 492 |
| Full Text Views | 12 | 12 | 3 |
| PDF Downloads | 14 | 14 | 5 |
Initial Magnetic Resonance Imaging Findings in Hepatic Fascioliasis and Serological and Radiological Response After Triclabendazole Treatment
Eun Jeong Won
Eun Jeong Won
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
Search for other papers by Eun Jeong Won in
Current site
Google Scholar
PubMed
Search for other papers by Eun Jeong Won in
Current site
Google Scholar
PubMed
Kyung-Won Kim
Kyung-Won Kim
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
Search for other papers by Kyung-Won Kim in
Current site
Google Scholar
PubMed
Search for other papers by Kyung-Won Kim in
Current site
Google Scholar
PubMed
Eui-Jin Chang
Eui-Jin Chang
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Eui-Jin Chang in
Current site
Google Scholar
PubMed
Search for other papers by Eui-Jin Chang in
Current site
Google Scholar
PubMed
Seongman Bae
Seongman Bae
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Seongman Bae in
Current site
Google Scholar
PubMed
Search for other papers by Seongman Bae in
Current site
Google Scholar
PubMed
Jiwon Jung
Jiwon Jung
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Jiwon Jung in
Current site
Google Scholar
PubMed
Search for other papers by Jiwon Jung in
Current site
Google Scholar
PubMed
Yong Pil Chong
Yong Pil Chong
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Yong Pil Chong in
Current site
Google Scholar
PubMed
Search for other papers by Yong Pil Chong in
Current site
Google Scholar
PubMed
Sang-Oh Lee
Sang-Oh Lee
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Sang-Oh Lee in
Current site
Google Scholar
PubMed
Search for other papers by Sang-Oh Lee in
Current site
Google Scholar
PubMed
Sang-Ho Choi
Sang-Ho Choi
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Sang-Ho Choi in
Current site
Google Scholar
PubMed
Search for other papers by Sang-Ho Choi in
Current site
Google Scholar
PubMed
Yang Soo Kim
Yang Soo Kim
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Yang Soo Kim in
Current site
Google Scholar
PubMed
Search for other papers by Yang Soo Kim in
Current site
Google Scholar
PubMed
Sung-Han Kim
Sung-Han Kim
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Sung-Han Kim in
Current site
Google Scholar
PubMed
Search for other papers by Sung-Han Kim in
Current site
Google Scholar
PubMed
Min Jae Kim
nahani99@gmail.com
Min Jae Kim
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Search for other papers by Min Jae Kim in
Current site
Google Scholar
PubMed
Search for other papers by Min Jae Kim in
Current site
Google Scholar
PubMed
ABSTRACT.
Fascioliasis, a food-borne trematodiasis, is a disease primarily identified in livestock, such as sheep and cattle. Human fascioliasis has been reported sporadically in Korea, but a recent increase in patients has been associated with a green vegetable juice delivery service. We aimed to investigate the serological and radiological findings of the patients treated for fascioliasis. Patients with peripheral eosinophilia, which is a positive antibody for Fasciola hepatica (F. hepatica) and liver abscess, were considered to have fascioliasis and were treated with triclabendazole at a dose of 10 mg/kg, administered twice. A total of 21 patients diagnosed with fascioliasis were included. Patients were categorized into the early and late diagnosis groups according to the time gap between the presentation and diagnosis. A comparison of initial magnetic resonance imaging (MRI) between the two groups revealed a filling defect of the bile duct that was more commonly observed in the late diagnosis group (72.7% versus 0%; P = 0.003). Hepatic abscess lesions resolved slowly, with 14.3%, 50%, and 85.7% of patients showing complete resolution on computed tomography 6, 12, and 24 months after treatment, respectively. The mean levels of anti-F. hepatica antibodies decreased after a 6-month follow-up (mean levels, onset versus 6-month, 12-month, or 24-month follow-up; 4.36 versus 3.29, 3.17, or 2.31, respectively; all P <0.01). Eosinophil counts reduced significantly 1 month after treatment and remained normal thereafter in both groups. This study suggests that MRI could be useful for diagnosing fascioliasis in a subgroup of patients and that hepatic abscesses and positive antibody results could last for several months after treatment.
- Supplemental Materials (PDF 613.59 KB)
Author Notes
Financial support: This research was supported by the
Disclosures: This study was approved by the ethical committee of Asan Medical Center (2023-1830). The requirement for informed consent was waived given the retrospective nature of the study.
Current contact information: Min Jae Kim, E-mail: nahani99@gmail.com. Eun Jeong Won, Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, E-mail: ejwon@amc.seoul.kr. Kyung-Won Kim, Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, E-mail: kyungwon.kim@amc.seoul.kr, Eui-Jin Chang, Jiwon Jung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim and Min Jae Kim, Department of Infectious diseases, Asan Medical Center ,University of Ulsan College of Medicine, Seoul, Korea, E-mails: radiohead0618@amc.seoul.kr, trueblue27@naver.com, drchong@amc.seoul.kr, soleemd@amc.seoul.kr, sangho@amc.seoul.kr, yskim@amc.seoul.kr, shkimmd@amc.seoul.kr, and nahani99@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Haseeb AN, el-Shazly AM, Arafa MA, Morsy AT, 2002. A review on fascioliasis in Egypt. J Egypt Soc Parasitol 32: 317–354.
-
2.
Sohn BW, Kang GS, Han TH, 1992. Studies on the optimal time for therapy of Fasciola spp. infected cattle in central area of Korea. Korean J Vet Serv 15: 1–6.
-
3.
Sohn BH, 2000. Current status and plan of the fascioliasis in cattle. J Korean Vet Med Assoc 39: 806–818.
-
4.
Kim YH, Kang KJ, Kwon JH, 2005. Four cases of hepatic fascioliasis mimicking cholangiocarcinoma. Korean J Hepatol 11: 169–175.
-
5.
World Health Organization, 2007. Report of the WHO Informal Meeting on use of triclabendazole in fascioliasis control, WHO headquarters, Geneva, Switzerland, 17–18 October 2006. Geneva, Switzerland: WHO.
-
6.
Apt W, Aguilera X, Vega F, Miranda C, Zulantay I, Perez C, Gabor M, Apt P, 1995. Treatment of human chronic fascioliasis with triclabendazole: Drug efficacy and serologic response. Am J Trop Med Hyg 52: 532–535.
-
7.
Choi S, Park S, Hong S, Shin H, Jung BK, Kim MJ, 2022. Green vegetable juice as a potential source of human fascioliasis in Korea. One Health 15: 100441.
-
8.
Jin Y, Kim EM, Choi MH, Oh MD, Hong ST, 2017. Significance of serology by multi-antigen ELISA for tissue helminthiases in Korea. J Korean Med Sci 32: 1118–1123.
-
9.
Venkatesh SK et al.; IPSCSG, 2022. Reporting standards for primary sclerosing cholangitis using MRI and MR cholangiopancreatography: Guidelines from MR Working Group of the International Primary Sclerosing Cholangitis Study Group. Eur Radiol 32: 923–937.
-
10.
Marcos LA, Terashima A, Gotuzzo E, 2008. Update on hepatobiliary flukes: Fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis 21: 523–530.
-
11.
Parkinson M, O’Neill SM, Dalton JP, 2007. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect 135: 669–674.
-
12.
Kaya M, Bestas R, Cetin S, 2011. Clinical presentation and management of Fasciola hepatica infection: Single-center experience. World J Gastroenterol 17: 4899–4904.
-
13.
Aksoy DY, Kerimoglu U, Oto A, Erguven S, Arslan S, Unal S, Batman F, Bayraktar Y, 2005. Infection with Fasciola hepatica. Clin Microbiol Infect 11: 859–861.
-
14.
Mas-Coma S, Bargues MD, Valero MA, 2014. Diagnosis of human fascioliasis by stool and blood techniques: Update for the present global scenario. Parasitology 141: 1918–1946.
-
15.
Schiappacasse RH, Mohammadi D, Christie AJ, 1985. Successful treatment of severe infection with Fasciola hepatica with praziquantel. J Infect Dis 152: 1339–1340.
-
16.
Dusak A, Onur MR, Cicek M, Firat U, Ren T, Dogra VS, 2012. Radiological imaging features of Fasciola hepatica infection – A pictorial review. J Clin Imaging Sci 2: 2.
-
17.
Richter J, Freise S, Mull R, Millán JC, 1999. Fascioliasis: Sonographic abnormalities of the biliary tract and evolution after treatment with triclabendazole. Trop Med Int Health 4: 774–781.
-
18.
Kang BK, Jung BK, Lee YS, Hwang IK, Lim H, Cho J, Hwang JH, Chai JY, 2014. A case of Fasciola hepatica infection mimicking cholangiocarcinoma and ITS-1 sequencing of the worm. Korean J Parasitol 52: 193–196.
-
19.
Hillyer GV, Serrano AE, 1983. The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani. Am J Trop Med Hyg 32: 350–358.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1428 | 1428 | 492 |
| Full Text Views | 12 | 12 | 3 |
| PDF Downloads | 14 | 14 | 5 |