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Dengue Virus Serotypes 1 and 2 Responsible for Dengue Burden in Amazonas: Epidemiological and Clinical Features

Fátima Burgos Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;

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Lourdes Ramírez-Orrego Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;

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Luis M. Rojas Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;
Laboratorio Referencial de Salud Pública, Dirección Regional de Salud de Amazonas, Chachapoyas, Peru;

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Rafael Tapia-Limonchi Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;
Facultad de Medicina, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru

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Carmen Gutierrez Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;
Facultad de Medicina, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru

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Stella M. Chenet Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru;
Facultad de Medicina, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru

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DOI:
https://doi.org/10.4269/ajtmh.24-0280
Volume/Issue:
Volume 112: Issue 1
Page(s):
189–193
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ABSTRACT.

The increase in dengue cases in Amazonas poses a public health risk. This study aimed to examine the circulating serotypes in the region of Amazonas, Peru, from 2021 to 2023, along with the associated clinical and epidemiological characteristics. Serotype identification was determined for 420 serum samples using a multiplex real-time reverse transcription–polymerase chain reaction assay, revealing that 194 patients were infected by dengue virus (DENV)-1 and 226 by DENV-2. Both serotypes co-circulated in all affected provinces. Warning signs were more frequent in patients with DENV-2 (P = 0.004), and the manifestation of abdominal pain was correlated with this serotype (P = 0.004), highlighting its association with severe forms of the disease. In conclusion, this study emphasizes the widespread circulation of DENV-1 and DENV-2 in Amazonas. Furthermore, it underscores the importance of real-time molecular surveillance that could provide an early prognosis of disease severity.

Author Notes

Financial support: This research was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (N° 050-2021-FONDECYT).

Current contact information: Fátima Burgos and Lourdes Ramírez-Orrego, Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru, E-mails: maria.burgos@untrm.edu.pe and lourdes.ramirez@untrm.edu.pe. Luis M. Rojas, Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru, and Laboratorio Referencial de Salud Pública, Dirección Regional de Salud de Amazonas, Chachapoyas, Peru, E-mail: luis.rojas@upch.edu.pe. Rafael Tapia-Limonchi, Carmen Gutierrez, and Stella M. Chenet, Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru, and Facultad de Medicina, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru, E-mails: rafael.tapia@untrm.edu.pe, carmen.gutierrez@untrm.edu.pe, and stella.chenet@untrm.edu.pe.

Address correspondence to Stella M. Chenet, Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza, Calle Higos Urco N° 342-350-356, Chachapoyas 01001, Amazonas, Peru. E-mail: stella.chenet@untrm.edu.pe
Copyright:
© American Society of Tropical Medicine and Hygiene 2025
Received:
25 Apr 2024
|
Accepted:
28 Jun 2024
|
Published Online:
29 Oct 2024
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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