Oral Candidiasis in Acute Flaviviral Infection

Mohammad Khalid Department of Emergency Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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Prithvishree Ravindra Department of Emergency Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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Praveen Kumar Tirlangi Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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Rachana Bhat Department of Emergency Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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Chandrashekar UK Department of Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Muralidhar Varma Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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Nitin Gupta Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India;

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ABSTRACT.

Kyasanur forest disease (KFD) is an endemic flaviviral hemorrhagic fever in south India. We report seven cases of oral candidiasis in patients from Karnataka, India, who presented in March and April 2024 with the first phase of KFD. Except for lymphopenia, no other risk factors for oral candidiasis were identified in these patients. All patients were managed with antifungals and did well at the 28-day follow-up. We report this case series to highlight the possibility of transient immunosuppression and the occurrence of opportunistic infections in flaviviral infections such as KFD.

Author Notes

Current contact information: Mohammed Khalid, Prithvishree Ravindra, and Rachana Bhat, Department of Emergency Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India, E-mails: khalid.mohammad@manipal.edu, prithvishree.r@manipal.edu, and rachana2806@gmail.com. Praveen Kumar Tirlangi, Muralidhar Varma, and Nitin Gupta, Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India, E-mails: praveenkuma.124@gmail.com, drmuralidharvarma@yahoo.co.in, and nityanitingupta@gmail.com. Chandrashekar UK, Department of Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India, E-mail: shekar.uk@manipal.edu.

Address correspondence to Nitin Gupta, Centre of Tropical Febrile Illness, Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Madhavnagar 576104, Karnataka, India. E-mail: nityanitingupta@gmail.com
  • 1.

    Gupta N, Wilson W, Neumayr A, Saravu K, 2022. Kyasanur forest disease: A state-of-the-art review. QJM Mon J Assoc Physicians 115: 351–358.

  • 2.

    Gupta N, Chunduru K, Safeer KM, Saravu K, 2021. Clinical and laboratory profile of patients with Kyasanur forest disease: A single-centre study of 192 patients from Karnataka, India. J Clin Virol Off Publ Pan Am Soc Clin Virol 135: 104735.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Vila T, Sultan AS, Montelongo-Jauregui D, Jabra-Rizk MA, 2020. Oral candidiasis: A disease of opportunity. J Fungi (Basel) 6: 15.

  • 4.

    Munivenkatappa A, Sahay RR, Yadav PD, Viswanathan R, Mourya DT, 2018. Clinical & epidemiological significance of Kyasanur forest disease. Indian J Med Res 148: 145–150.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Vogt MB, Lahon A, Arya RP, Clinton JLS, Rico-Hesse R, 2019. Dengue viruses infect human megakaryocytes, with probable clinical consequences. PLoS Negl Trop Dis 13: e0007837.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Das D, Sahu SN, Panda PK, Panda M, 2024. Oro-pharyngeal candidiasis in two dengue patients. Cureus 16: e52627.

  • 7.

    Malavige GN, Ranatunga PK, Velathanthiri VGNS, Fernando S, Karunatilaka DH, Aaskov J, Seneviratne SL, 2006. Patterns of disease in Sri Lankan dengue patients. Arch Dis Child 91: 396–400.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Trunfio M, Savoldi A, Viganò O, d’Arminio Monforte A, 2017. Bacterial coinfections in dengue virus disease: What we know and what is still obscure about an emerging concern. Infection 45: 1–10.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Zhou ZX, Yin XD, Zhang Y, Shao QH, Mao XY, Hu WJ, Shen YL, Zhao B, Li ZL, 2022. Antifungal drugs and drug-induced liver injury: A real-world study leveraging the FDA Adverse Event Reporting System Database. Front Pharmacol 13: 891336.

    • PubMed
    • Search Google Scholar
    • Export Citation
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