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1.
Tande AJ, Patel R, 2014. Prosthetic joint infection. Clin Microbiol Rev 27: 302–345.
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2.
Porrino J, Wang A, Moats A, Mulcahy H, Kani K, 2020. Prosthetic joint infections: Diagnosis, management, and complications of the two-stage replacement arthroplasty. Skeletal Radiol 49: 847–859.
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3.
Bauer TW, Parvizi J, Kobayashi N, Krebs V, 2006. Diagnosis of periprosthetic infection. J Bone Joint Surg Am 88: 869–882.
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4.
Parvizi J, Tan TL, Goswami K, Higuera C, Della Valle C, Chen AF, Shohat N, 2018. The 2018 definition of periprosthetic hip and knee infection: An evidence-based and validated criteria. J Arthroplasty 33: 1309–1314.e2.
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5.
Sebastian S, Malhotra R, Sreenivas V, Kapil A, Chaudhry R, Dhawan B, 2019. A clinico-microbiological study of prosthetic joint infections in an Indian tertiary care hospital: Role of universal 16S rRNA gene polymerase chain reaction and sequencing in diagnosis. Indian J Orthop 53: 646–654.
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6.
Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J, 2008. Periprosthetic joint infection: The incidence, timing, and predisposing factors. Clin Orthop Relat Res 466: 1710–1715.
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7.
Patel R, 2023. Periprosthetic joint infection. N Engl J Med 388: 251–262.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 317 | 317 | 80 |
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Microbiological Profile of Periprosthetic Joint Infections: A Retrospective Analysis from North India
Souradeep Chowdhury
Souradeep Chowdhury
Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India;
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Sunit Sikdar
Sunit Sikdar
Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India;
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Rajesh Malhotra
Rajesh Malhotra
Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India;
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Benu Dhawan
dhawanb@gmail.com
Benu Dhawan
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
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ABSTRACT.
With the rise in total joint arthroplasties, prosthetic joint infections (PJIs) have become a significant complication, leading to high morbidity. The causative organisms of PJIs vary by region, and the rates of drug-resistant organisms are growing, thus complicating the initial empiric choice of antibiotics. This retrospective study analyzed records of patients with orthopedic implants and intraoperative tissue samples sent for sonication and culture at a tertiary care hospital in India. The most common organism was Staphylococcus aureus (14 out of 86 bacterial isolates, 16.3%), followed by Pseudomonas aeruginosa (12 out of 86, 13.9%), and both Staphylococcus epidermidis and Klebsiella pneumoniae (11 each out of 86, 12.8%). There was a high prevalence of multidrug-resistant organisms, and 35% of the gram-negative organisms were carbapenem resistant. Our study reveals that in our setting, PJIs are chiefly driven by multidrug resistant gram-negative bacteria.
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Author Notes
Current contact information: Souradeep Chowdhury and Sunit Sikdar, Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India, E-mails: chowdhurysouradeep150@gmail.com and sikdarsunit@gmail.com. Rajesh Malhotra, Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India, E-mail: rmalhotra62@gmail.com. Benu Dhawan, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: dhawanb@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tande AJ, Patel R, 2014. Prosthetic joint infection. Clin Microbiol Rev 27: 302–345.
-
2.
Porrino J, Wang A, Moats A, Mulcahy H, Kani K, 2020. Prosthetic joint infections: Diagnosis, management, and complications of the two-stage replacement arthroplasty. Skeletal Radiol 49: 847–859.
-
3.
Bauer TW, Parvizi J, Kobayashi N, Krebs V, 2006. Diagnosis of periprosthetic infection. J Bone Joint Surg Am 88: 869–882.
-
4.
Parvizi J, Tan TL, Goswami K, Higuera C, Della Valle C, Chen AF, Shohat N, 2018. The 2018 definition of periprosthetic hip and knee infection: An evidence-based and validated criteria. J Arthroplasty 33: 1309–1314.e2.
-
5.
Sebastian S, Malhotra R, Sreenivas V, Kapil A, Chaudhry R, Dhawan B, 2019. A clinico-microbiological study of prosthetic joint infections in an Indian tertiary care hospital: Role of universal 16S rRNA gene polymerase chain reaction and sequencing in diagnosis. Indian J Orthop 53: 646–654.
-
6.
Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J, 2008. Periprosthetic joint infection: The incidence, timing, and predisposing factors. Clin Orthop Relat Res 466: 1710–1715.
-
7.
Patel R, 2023. Periprosthetic joint infection. N Engl J Med 388: 251–262.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 317 | 317 | 80 |
| Full Text Views | 13 | 13 | 8 |
| PDF Downloads | 13 | 13 | 7 |