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1.
Kumar S, Ghosh RS, Iyer H, Ray A, Vannice K, MacLennan C, Shewchuk T, Steele D, 2021. Typhoid in India: An age-old problem with an existing solution. J Infect Dis 224 (Suppl 5 ):S469–S474.
-
2.
John J, Van Aart CJ, Grassly NC, 2016. The burden of typhoid and paratyphoid in India: Systematic review and meta-analysis. PLoS Negl Trop Dis 10: e0004616.
-
3.
Mylavarapu NA, Rajangam M, Sharma P, John SM, Goyal P, Singh S, Verma S, Angurana SK, 2024. A tale of complicated enteric fever: Common disease with unusual complications. Pediatr Infect Dis J 43: e27–e28.
-
4.
John J, et al., 2023. Burden of typhoid and paratyphoid fever in India. N Engl J Med 388: 1491–1500.
-
5.
Parajuli B, Angurana SK, Awasthi P, Nallasamy K, Baranwal A, Bansal A, Bansal D, Rawat A, Varma N, Jayashree M, 2021. Hemophagocytic lymphohistiocytosis in a PICU of a developing economy: Clinical profile, intensive care needs, outcome, and predictors of mortality. Pediatr Crit Care Med 22: e44–e57.
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6.
Birkhold M, et al., 2023. Characterization of typhoid intestinal perforation in Africa: Results from the severe typhoid fever surveillance in Africa. Open Forum Infect Dis 10 (Suppl 1 ):S67–S73.
-
7.
Srinivasan M, Sindhu KN, Kumar JS, Ramasamy RK, Pragasam AK, Aasaithampi P, Mohan VR, Kang G, 2022. Outbreak of typhoid fever in children of urban Vellore: A report from the Surveillance for Enteric Fever in India cohort. Am J Trop Med Hyg 107: 82–85.
-
8.
Laps AM, Foster CB, Laurens MB, 2020. High-dose dexamethasone in a child with enteric encephalopathy caused by Salmonella enterica serovar Typhi. Pediatr Infect Dis J 39: e49–e51.
-
9.
Majid A, Bin Waqar SH, Rehan A, Kumar S, 2019. From gut to heart: Havoc in a young patient with typhoid-associated cardiomyopathy. Cureus 11: e5049.
-
10.
Biber A, Nof E, Schwartz E, 2019. Cardiac involvement in travelers with enteric fever. Am J Trop Med Hyg 100: 1098–1100.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2637 | 2637 | 135 |
| Full Text Views | 22 | 22 | 10 |
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Enteric Fever with Intussusception, Myocardial Dysfunction, Encephalopathy, and Hemophagocytic Lymphohistiocytosis in an Indian Child
Puspraj Awasthi
Puspraj Awasthi
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Suresh Kumar Angurana
sureshangurana@gmail.com
Suresh Kumar Angurana
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Karthi Nallasamy
Karthi Nallasamy
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Arun Bansal
Arun Bansal
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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ABSTRACT.
Enteric fever is an endemic disease in developing and low-middle income countries due to poor sanitation and hygiene. The majority of cases have mild symptoms and resolve with oral or intravenous antibiotics. However, multisystemic involvement due to enteric fever requiring intensive care is not uncommon and is associated with high mortality and morbidity. We report a 5-year-old boy from Mohali, Punjab, India with enteric fever who had fulminant course with several complications including transient intussusception, myocardial dysfunction, encephalopathy, and secondary hemophagocytic lymphohistiocytosis. He was treated with ceftriaxone, vasoactive drugs, mechanical ventilation, dexamethasone, and intravenous immunoglobulin and had favorable outcome despite life-threatening complications.
Author Notes
Current contact information: Puspraj Awasthi, Suresh Kumar Angurana, Karthi Nallasamy, and Arun Bansal, Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mails: prapgi697@gmail.com, sureshangurana@gmail.com, ny.karthi@gmail.com, and drarunbansal@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Kumar S, Ghosh RS, Iyer H, Ray A, Vannice K, MacLennan C, Shewchuk T, Steele D, 2021. Typhoid in India: An age-old problem with an existing solution. J Infect Dis 224 (Suppl 5 ):S469–S474.
-
2.
John J, Van Aart CJ, Grassly NC, 2016. The burden of typhoid and paratyphoid in India: Systematic review and meta-analysis. PLoS Negl Trop Dis 10: e0004616.
-
3.
Mylavarapu NA, Rajangam M, Sharma P, John SM, Goyal P, Singh S, Verma S, Angurana SK, 2024. A tale of complicated enteric fever: Common disease with unusual complications. Pediatr Infect Dis J 43: e27–e28.
-
4.
John J, et al., 2023. Burden of typhoid and paratyphoid fever in India. N Engl J Med 388: 1491–1500.
-
5.
Parajuli B, Angurana SK, Awasthi P, Nallasamy K, Baranwal A, Bansal A, Bansal D, Rawat A, Varma N, Jayashree M, 2021. Hemophagocytic lymphohistiocytosis in a PICU of a developing economy: Clinical profile, intensive care needs, outcome, and predictors of mortality. Pediatr Crit Care Med 22: e44–e57.
-
6.
Birkhold M, et al., 2023. Characterization of typhoid intestinal perforation in Africa: Results from the severe typhoid fever surveillance in Africa. Open Forum Infect Dis 10 (Suppl 1 ):S67–S73.
-
7.
Srinivasan M, Sindhu KN, Kumar JS, Ramasamy RK, Pragasam AK, Aasaithampi P, Mohan VR, Kang G, 2022. Outbreak of typhoid fever in children of urban Vellore: A report from the Surveillance for Enteric Fever in India cohort. Am J Trop Med Hyg 107: 82–85.
-
8.
Laps AM, Foster CB, Laurens MB, 2020. High-dose dexamethasone in a child with enteric encephalopathy caused by Salmonella enterica serovar Typhi. Pediatr Infect Dis J 39: e49–e51.
-
9.
Majid A, Bin Waqar SH, Rehan A, Kumar S, 2019. From gut to heart: Havoc in a young patient with typhoid-associated cardiomyopathy. Cureus 11: e5049.
-
10.
Biber A, Nof E, Schwartz E, 2019. Cardiac involvement in travelers with enteric fever. Am J Trop Med Hyg 100: 1098–1100.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2637 | 2637 | 135 |
| Full Text Views | 22 | 22 | 10 |
| PDF Downloads | 31 | 31 | 10 |