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1.
Limmathurotsakul D, et al., 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
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2.
Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ, 2024. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol 22: 155–169.
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3.
Somayaji R, Hantrakun V, Teparrukkul P, Wongsuvan G, Rudd KE, Day NPJ, West TE, Limmathurotsakul D, 2021. Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: A prospective observational study (Ubon-sepsis). PLoS Negl Trop Dis 15: e0009704.
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Currie BJ, et al., 2000. Endemic melioidosis in tropical northern Australia: A 10-year prospective study and review of the literature. Clin Infect Dis 31: 981–986.
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Laohapensang K, Rutherford RB, Arworn S, 2010. Infected aneurysm. Ann Vasc Dis 3: 16–23.
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6.
Wu H, Wang X, Zhou X, Wu Z, Wang Y, Pan M, Lu B, 2020. Mycotic aneurysm secondary to melioidosis in China: A series of eight cases and a review of literature. PLoS Negl Trop Dis 14: e0008525.
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Zheng X, Xia Q, Xia L, Li W, 2019. Endemic melioidosis in Southern China: Past and present. Trop Med Infect Dis 4: 39.
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Jesinger RA, Thoreson AA, Lamba R, 2013. Abdominal and pelvic aneurysms and pseudoaneurysms: Imaging review with clinical, radiologic, and treatment correlation. Radiographics 33: E71–E96.
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Wang Y, et al., 2022. A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics. Infect Dis Poverty 11: 87.
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Case Report: Burkholderia pseudomallei Infection with Sepsis and Aortic Pseudoaneurysm
Dai Kuang
Dai Kuang
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China;
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Wei Liu
Wei Liu
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China;
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Daohu Chen
Daohu Chen
The Second Affiliated Hospital of Hainan Medical University, Haikou, China;
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Jingsi Jiang
Jingsi Jiang
School of Hainan Provincial Drug Safety Evaluation Research Center, Hainan Medical University, Haikou, China
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Yi Wang
wayne0108@126.com
Yi Wang
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China;
The Second Affiliated Hospital of Hainan Medical University, Haikou, China;
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The Second Affiliated Hospital of Hainan Medical University, Haikou, China;
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Qianfeng Xia
xiaqianfeng@hainmc.edu.cn
Qianfeng Xia
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China;
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ABSTRACT.
Burkholderia pseudomallei is a Gram-negative bacterium found predominantly in tropical and subtropical regions. A 49-year-old individual with type 2 diabetes in Hainan, China, with a 4-month history of intermittent fever and 20 days of chest-back pain was diagnosed with aortic pseudoaneurysm through a computerized tomography scan. Burkholderia pseudomallei was identified through bacteriological examination of the patient’s blood. The patient received supportive care, with management of hyperthermia, heart rate, blood pressure, and blood glucose levels. Intravenous meropenem and oral sulfamethoxazole were administered for anti-infection treatment. Within 10 days, the patient’s temperature normalized, vital signs stabilized, chest pain subsided, and blood cultures cleared. This case highlights the potential severity of B. pseudomallei infections, underscoring the critical role of appropriate antibiotics, supportive care, and long-term follow-up in ensuring comprehensive management and preventing further transmission.
Author Notes
Financial support: This study was funded under the
Current contact information: Dai Kuang, Wei Liu, and Qianfeng Xia, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China, E-mails: daikuang@hainmc.edu.cn, liuwei03@hainmc.edu.cn and xiaqianfeng@hainmc.edu.cn; Daohu Chen, The Second Affiliated Hospital of Hainan Medical University, Haikou, China, E-mail: chendaohu3@163.com; Jingsi Jiang, School of Hainan Provincial Drug Safety Evaluation Research Center, Hainan Medical University, Haikou, China, E-mail: jjs1103@sina.com; Yi Wang, Department of Organ Transplantation, The Second Affiliated Hospital of Hainan Medical University, Haikou, China, E-mail: wayne0108@126.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Limmathurotsakul D, et al., 2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
2.
Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ, 2024. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol 22: 155–169.
-
3.
Somayaji R, Hantrakun V, Teparrukkul P, Wongsuvan G, Rudd KE, Day NPJ, West TE, Limmathurotsakul D, 2021. Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: A prospective observational study (Ubon-sepsis). PLoS Negl Trop Dis 15: e0009704.
-
4.
Currie BJ, et al., 2000. Endemic melioidosis in tropical northern Australia: A 10-year prospective study and review of the literature. Clin Infect Dis 31: 981–986.
-
5.
Laohapensang K, Rutherford RB, Arworn S, 2010. Infected aneurysm. Ann Vasc Dis 3: 16–23.
-
6.
Wu H, Wang X, Zhou X, Wu Z, Wang Y, Pan M, Lu B, 2020. Mycotic aneurysm secondary to melioidosis in China: A series of eight cases and a review of literature. PLoS Negl Trop Dis 14: e0008525.
-
7.
Fang Y, Chen H, Li YL, Li Q, Ye ZJ, Mao XH, 2015. Melioidosis in Hainan, China: A restrospective study. Trans R Soc Trop Med Hyg 109: 636–642.
-
8.
Zheng X, Xia Q, Xia L, Li W, 2019. Endemic melioidosis in Southern China: Past and present. Trop Med Infect Dis 4: 39.
-
9.
Jesinger RA, Thoreson AA, Lamba R, 2013. Abdominal and pelvic aneurysms and pseudoaneurysms: Imaging review with clinical, radiologic, and treatment correlation. Radiographics 33: E71–E96.
-
10.
Saad NE, Saad WE, Davies MG, Waldman DL, Fultz PJ, Rubens DJ, 2005. Pseudoaneurysms and the role of minimally invasive techniques in their management. Radiographics 25 (Suppl 1 ):S173–S189.
-
11.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
12.
Currie BJ, et al., 2021. The Darwin Prospective Melioidosis Study: A 30-year prospective, observational investigation. Lancet Infect Dis 21: 1737–1746.
-
13.
Smith S, Hanson J, Currie BJ, 2018. Melioidosis: An Australian perspective. Trop Med Infect Dis 3: 27.
-
14.
Wang Y, et al., 2022. A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics. Infect Dis Poverty 11: 87.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4397 | 4397 | 123 |
| Full Text Views | 76 | 76 | 7 |
| PDF Downloads | 98 | 98 | 8 |