ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Werthelm HFL, Nghia HDT, Taylor W, Schultsz C, 2009. Streptococcus suis: An emerging human pathogen. Clin Infect Dis 48: 617–625.
-
2.
World Bank, 2013. Data—Population Total. Available at: https://data.worldbank.org/indicator/SP.POP.TOTL/. Accessed June 25, 2013.
-
3.
Yu H, et al., 2006. Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis 12: 914–920.
-
4.
Brizuela J, et al., 2023. Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand. Microb Genom 9: mgen000952.
-
5.
Mai NTH, et al., 2008. Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis 46: 659–667.
-
6.
Nghia HDT, et al., 2011. Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS One 6: e17604.
-
7.
Man NTT, Dorny P, Lebailly P, Chau LTM, Huyen NTT, Dermauw V, 2020. Mapping the pork value chain in Vietnam: A systematic review. Trop Anim Health Prod 52: 2799–2808.
-
8.
Lemke U, Mergenthaler M, Roessler R, Huyen LTT, Herold P, Kaufmann B, Zarata A, 2008. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 23.
-
9.
Statista, 2023. Pork Production in Vietnam from 2018 to 2023. Available at: https://www.statista.com/statistics/661016/vietnam-pig-production/. Accessed April 30, 2024.
-
10.
Lunha K, Chumpol W, Samngamnim S, Jiemsup S, Assavacheep P, Yongkiettrakul S, 2022. Antimicrobial susceptibility of Streptococcus suis isolated from diseased pigs in Thailand, 2018–2020. Antibiotics (Basel) 11: 410.
-
11.
Uruén C, García C, Fraile L, Tommassen J, Arenas J, 2022. How Streptococcus suis escapes antibiotic treatments. Vet Res 53: 91.
-
12.
Karavanonth N, Sukkasem I, Songkram S, Jirapongsa C, 2019. Outbreak of human Streptococcus suis cases in Chum Phuang District, Nakhon Ratchasima Province, Thailand, 2018. OSIR 12: 136–143.
-
13.
Huong VTL, et al., 2014. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis 20: 1105–1114.
-
14.
Goyette-Desjardins G, Auger JP, Xu J, Segura M, Gottschalk M, 2014. Streptococcus suis, an important pig pathogen and emerging zoonotic agent – An update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect 3: e45.
-
15.
Callejo R, Zheng H, Du P, Prieto M, Xu J, Zielinski G, Auger JP, Gottschalk M, 2016. Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans. JMM Case Rep 3: e005066.
-
16.
Ip M, Fung KS, Chi F, Cheuk ES, Chau SS, Wong BW, Lui S, Hui M, Lai RW, Chan PK, 2007. Streptococcus suis in Hong Kong. Diagn Microbiol Infect Dis 57: 15–20.
-
17.
Susilawathi NM, Tarini NMA, Fatmawati NND, Mayura PIB, Suryapraba AAA, Subrata M, Sudewi AAR, Mahardika GN, 2019. Streptococcus suis-associated meningitis, Bali, Indonesia, 2014–2017. Emerg Infect Dis 25: 2235–2242.
-
18.
Wertheim HFL, et al., 2009. Streptococcus suis, an important cause of adult bacterial meningitis in Northern Vietnam. PLoS One 4: e5973.
-
19.
Nguyen D-Q, Renwick J, McGregor J, 2014. Variations of surface temperature and rainfall in Vietnam from 1971 to 2010. Int J Climatol 34: 249–264.
-
20.
Kerdsin A, 2022. Human Streptococcus suis infections in Thailand: Epidemiology, clinical features, genotypes, and susceptibility. Trop Med Infect Dis 7: 359.
-
21.
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, 2015. Streptococcus suis meningitis: A systematic review and meta-analysis. PLoS Negl Trop Dis 9: e0004191.
-
22.
Rayanakorn A, Katip W, Goh BH, Oberdorfer P, Lee LH, 2020. A risk scoring system for predicting Streptococcus suis hearing loss: A 13-year retrospective cohort study. PLoS One 15: e0228488.
-
23.
Khadthasrima N, et al., 2008. Human Streptococcus suis outbreak in Phayao province, Thailand, 2007. OSIR 1: 4–7.
-
24.
Arends JP, Zanen HC, 1988. Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10: 131–137.
-
25.
Takeuchi D, et al., 2017. Impact of a food safety campaign on Streptococcus suis infection in humans in Thailand. Am J Trop Med Hyg 96: 1370–1377.
-
26.
van de Beek D, de Gans J, Tunkel AR, Wijdicks EF, 2006. Community-acquired bacterial meningitis in adults. N Engl J Med 354: 44–53.
-
27.
Nguyen THM, et al., 2007. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 357: 2431–2440.
-
28.
Zhang C, et al., 2020. Capsular serotypes, antimicrobial susceptibility, and the presence of transferable oxazolidinone resistance genes in Streptococcus suis isolated from healthy pigs in China. Vet Microbiol 247: 108750.
-
29.
Petrocchi-Rilo M, Martínez-Martínez S, Aguarón-Turrientes Á, Roca-Martínez E, García-Iglesias MJ, Pérez-Fernández E, González-Fernández A, Herencia-Lagunar E, Gutiérrez-Martín CB, 2021. Anatomical site, typing, virulence gene profiling, antimicrobial susceptibility and resistance genes of Streptococcus suis isolates recovered from pigs in Spain. Antibiotics (Basel) 10: 707.
-
30.
Hendriksen RS, et al., 2008. Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002–2004: The ARBAO-II study. Acta Vet Scand 50: 19.
-
31.
Varela NP, Gadbois P, Thibault C, Gottschalk M, Dick P, Wilson J, 2013. Antimicrobial resistance and prudent drug use for Streptococcus suis. Anim Health Res Rev 14: 68–77.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3490 | 3490 | 156 |
| Full Text Views | 97 | 97 | 13 |
| PDF Downloads | 83 | 83 | 12 |
Streptococcus suis-Associated Meningitis in a Southern Region of Vietnam
Nguyen Huu Thanh
Nguyen Huu Thanh
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
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Doan Thanh Huy
Doan Thanh Huy
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
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Vo Thi Tram Anh
Vo Thi Tram Anh
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
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Nguyen Ngoc Anh
Nguyen Ngoc Anh
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
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Nguyen Thi Thu Uyen
Nguyen Thi Thu Uyen
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
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Nguyen Ho Hong Hanh
Nguyen Ho Hong Hanh
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
Department of Infectious Disease, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
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Department of Infectious Disease, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
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Nguyen Hoan Phu
phunh@oucru.org
Nguyen Hoan Phu
School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam;
Department of Infectious Disease, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
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Department of Infectious Disease, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
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ABSTRACT.
Streptococcus suis is the most common and severe cause of meningitis in Vietnam, but the recent data about epidemiological characteristics and sequelae are still inadequate. We performed a retrospective study to describe the epidemiology, clinical characteristics, and outcomes of patients with S. suis-associated meningitis. A retrospective study was carried out by searching records from the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, between January 2016 and January 2020. All data concerning epidemiological, clinical, and subclinical characteristics and treatment results were collected and analyzed. Over the study period, 153 cases were included in this study, with 95 cases occurring in the 2016–2017 period. The median age of all patients was 52 years (range, 29–90 years), and 70.6% of patients were male. Fifty-two patients (34%) were farmers, and the Mekong Delta was the region with the highest number of cases (60.1%). The most frequent manifestation of infection was fever (151/153, 98.7%), followed by hearing loss (64/153, 41.8%), and one patient (0.7%) died. All isolates remained susceptible to ceftriaxone, penicillin, vancomycin, and levofloxacin, whereas 99.2% of isolates were resistant to tetracycline. Occupational exposure to pigs and the consumption of contaminated food have been identified as primary risk factors associated with this zoonosis, and our study found no significant changes in epidemiological factors compared with past data. The Mekong Delta continues to be the most affected region for S. suis meningitis in southern Vietnam, with S. suis serotype 2 remaining the most relevant agent.
- Supplemental Materials (PDF 298.71 KB)
Author Notes
Financial support: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Disclosure: This study was approved by the Ethics Committee of the School of Medicine, Vietnam National University - Ho Chi Minh City, Vietnam.
Current contact information: Nguyen Huu Thanh, College of Health Sciences, VinUniversity, Hanoi, Vietnam, E-mail: nhthanh.dr1@gmail.com. Doan Thanh Huy, Vo Thi Tram Anh, Nguyen Ngoc Anh, and Nguyen Thi Thu Uyen, School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam, E-mails: dthuy.stu14@medvnu.edu.vn, vttanh.stu14@medvnu.edu.vn, nnanh.stu14@medvnu.edu.vn, and nttuyen2.stu14@medvnu.edu.vn. Nguyen Ho Hong Hanh and Nguyen Hoan Phu, University of Health Sciences, Vietnam National University, Ho Chi Minh City, Vietnam and Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, E-mails: phunh@oucru.org and honghanh.nguyenho@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Werthelm HFL, Nghia HDT, Taylor W, Schultsz C, 2009. Streptococcus suis: An emerging human pathogen. Clin Infect Dis 48: 617–625.
-
2.
World Bank, 2013. Data—Population Total. Available at: https://data.worldbank.org/indicator/SP.POP.TOTL/. Accessed June 25, 2013.
-
3.
Yu H, et al., 2006. Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis 12: 914–920.
-
4.
Brizuela J, et al., 2023. Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand. Microb Genom 9: mgen000952.
-
5.
Mai NTH, et al., 2008. Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis 46: 659–667.
-
6.
Nghia HDT, et al., 2011. Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS One 6: e17604.
-
7.
Man NTT, Dorny P, Lebailly P, Chau LTM, Huyen NTT, Dermauw V, 2020. Mapping the pork value chain in Vietnam: A systematic review. Trop Anim Health Prod 52: 2799–2808.
-
8.
Lemke U, Mergenthaler M, Roessler R, Huyen LTT, Herold P, Kaufmann B, Zarata A, 2008. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 23.
-
9.
Statista, 2023. Pork Production in Vietnam from 2018 to 2023. Available at: https://www.statista.com/statistics/661016/vietnam-pig-production/. Accessed April 30, 2024.
-
10.
Lunha K, Chumpol W, Samngamnim S, Jiemsup S, Assavacheep P, Yongkiettrakul S, 2022. Antimicrobial susceptibility of Streptococcus suis isolated from diseased pigs in Thailand, 2018–2020. Antibiotics (Basel) 11: 410.
-
11.
Uruén C, García C, Fraile L, Tommassen J, Arenas J, 2022. How Streptococcus suis escapes antibiotic treatments. Vet Res 53: 91.
-
12.
Karavanonth N, Sukkasem I, Songkram S, Jirapongsa C, 2019. Outbreak of human Streptococcus suis cases in Chum Phuang District, Nakhon Ratchasima Province, Thailand, 2018. OSIR 12: 136–143.
-
13.
Huong VTL, et al., 2014. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis 20: 1105–1114.
-
14.
Goyette-Desjardins G, Auger JP, Xu J, Segura M, Gottschalk M, 2014. Streptococcus suis, an important pig pathogen and emerging zoonotic agent – An update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect 3: e45.
-
15.
Callejo R, Zheng H, Du P, Prieto M, Xu J, Zielinski G, Auger JP, Gottschalk M, 2016. Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans. JMM Case Rep 3: e005066.
-
16.
Ip M, Fung KS, Chi F, Cheuk ES, Chau SS, Wong BW, Lui S, Hui M, Lai RW, Chan PK, 2007. Streptococcus suis in Hong Kong. Diagn Microbiol Infect Dis 57: 15–20.
-
17.
Susilawathi NM, Tarini NMA, Fatmawati NND, Mayura PIB, Suryapraba AAA, Subrata M, Sudewi AAR, Mahardika GN, 2019. Streptococcus suis-associated meningitis, Bali, Indonesia, 2014–2017. Emerg Infect Dis 25: 2235–2242.
-
18.
Wertheim HFL, et al., 2009. Streptococcus suis, an important cause of adult bacterial meningitis in Northern Vietnam. PLoS One 4: e5973.
-
19.
Nguyen D-Q, Renwick J, McGregor J, 2014. Variations of surface temperature and rainfall in Vietnam from 1971 to 2010. Int J Climatol 34: 249–264.
-
20.
Kerdsin A, 2022. Human Streptococcus suis infections in Thailand: Epidemiology, clinical features, genotypes, and susceptibility. Trop Med Infect Dis 7: 359.
-
21.
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, 2015. Streptococcus suis meningitis: A systematic review and meta-analysis. PLoS Negl Trop Dis 9: e0004191.
-
22.
Rayanakorn A, Katip W, Goh BH, Oberdorfer P, Lee LH, 2020. A risk scoring system for predicting Streptococcus suis hearing loss: A 13-year retrospective cohort study. PLoS One 15: e0228488.
-
23.
Khadthasrima N, et al., 2008. Human Streptococcus suis outbreak in Phayao province, Thailand, 2007. OSIR 1: 4–7.
-
24.
Arends JP, Zanen HC, 1988. Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10: 131–137.
-
25.
Takeuchi D, et al., 2017. Impact of a food safety campaign on Streptococcus suis infection in humans in Thailand. Am J Trop Med Hyg 96: 1370–1377.
-
26.
van de Beek D, de Gans J, Tunkel AR, Wijdicks EF, 2006. Community-acquired bacterial meningitis in adults. N Engl J Med 354: 44–53.
-
27.
Nguyen THM, et al., 2007. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 357: 2431–2440.
-
28.
Zhang C, et al., 2020. Capsular serotypes, antimicrobial susceptibility, and the presence of transferable oxazolidinone resistance genes in Streptococcus suis isolated from healthy pigs in China. Vet Microbiol 247: 108750.
-
29.
Petrocchi-Rilo M, Martínez-Martínez S, Aguarón-Turrientes Á, Roca-Martínez E, García-Iglesias MJ, Pérez-Fernández E, González-Fernández A, Herencia-Lagunar E, Gutiérrez-Martín CB, 2021. Anatomical site, typing, virulence gene profiling, antimicrobial susceptibility and resistance genes of Streptococcus suis isolates recovered from pigs in Spain. Antibiotics (Basel) 10: 707.
-
30.
Hendriksen RS, et al., 2008. Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002–2004: The ARBAO-II study. Acta Vet Scand 50: 19.
-
31.
Varela NP, Gadbois P, Thibault C, Gottschalk M, Dick P, Wilson J, 2013. Antimicrobial resistance and prudent drug use for Streptococcus suis. Anim Health Res Rev 14: 68–77.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3490 | 3490 | 156 |
| Full Text Views | 97 | 97 | 13 |
| PDF Downloads | 83 | 83 | 12 |