ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Oz FN , Tanir G , Simsek G , Kaya NG , Akin I , 2013. A case of underdiagnosed Brucella meningitis presented with hearing loss. Infect Dis Clin Pract 21: 136–138.
-
2.
Bricker BJ , Ewalt DR , Halling SM , 2003. Brucella ‘HOOF-Prints’: strain typing by multi-locus analysis of variable number tandem repeats (VNTRs). BMC Microbiol 3: 15.
-
3.
American Academy of Pediatrics , 2021. Red Book: 2021–2024 Report of the Committee on Infectious Diseases. Itasca, IL; American Academy of Pediatrics.
-
4.
Gul HC , Erdem H , Bek S , 2009. Overview of neurobrucellosis: A pooled analysis of 187 cases. Int J Infect Dis 13: 339–343.
-
5.
Akdeniz H , Irmak H , Anlar O , Demiroz AP , 1998. Central nervous system brucellosis: Presentation, diagnosis and treatment. J Infect 36: 297–301.
-
6.
Qasim SS , Baharoon S , Layqah L , 2021. A case of seronegative pediatric neurobrucellosis presenting with ataxia. Cureus 13: e12540.
-
7.
Sanchez-Sousa A , Torres C , Campello MG , Garcia C , Parras F , Cercenado E , Baquero F , 1990. Serological diagnosis of neurobrucellosis. J Clin Pathol 43: 79–81.
-
8.
Araj GF , Lulu AR , Saadah MA , Mousa AM , Strannegard IL , Shakir RA , 1986. Rapid diagnosis of central nervous system brucellosis by ELISA. J Neuroimmunol 12: 173–182.
-
9.
Guven T , Ugurlu K , Ergonul O , Celikbas AK , Gok SE , Comoglu S , Baykam N , Dokuzoguz B , 2013. Neurobrucellosis: Clinical and diagnostic features. Clin Infect Dis 56: 1407–1412.
-
10.
Al-Sous MW , Bohlega S , Al-Kawi MZ , Alwatban J , McLean DR , 2004. Neurobrucellosis: Clinical and neuroimaging correlation. AJNR Am J Neuroradiol 25: 395–401.
-
11.
Mousa AR , Koshy TS , Araj GF , Marafie AA , Muhtaseb SA , Al-Mudallal DS , Busharetulla MS , 1986. Brucella meningitis: Presentation, diagnosis and treatment—a prospective study of ten cases. Q J Med 60: 873–885.
-
12.
CDC , 2010. Brucellosis (Brucella spp.). 2010 Case Definition. Available at: https://ndc.services.cdc.gov/case-definitions/brucellosis-2010/. Accessed September 19, 2023.
-
13.
Al-Tawfiq JA , 2008. Therapeutic options for human brucellosis. Expert Rev Anti Infect Ther 6: 109–120.
-
14.
Young EJ , 1995. An overview of human brucellosis. Clin Infect Dis 21: 283–290.
-
15.
Alp E , Doğanay M , Willke Topçu A , Söyletir G & Doğanay M Infectious Diseases and Microbiology, 4th edition. Istanbul, Turkey: Nobel Medical Bookstores, 1827–1834.
-
16.
Akcam FZ , Akcam M , Yilmaz M , Temei E , 2020. Neurobrucellosis: Two cases, two different presentation. Turk J Neurol. 26: 342–345.
-
17.
Erdem H et al., 2012. Efficacy and tolerability of antibiotic combinations in neurobrucellosis: Results of the Istanbul study. Antimicrob Agents Chemother 56: 1523–1528.
-
18.
Yetkin MA , Bulut C , Erdinc FS , Oral B , Tulek N , 2006. Evaluation of the clinical presentations in neurobrucellosis. Int J Infect Dis 10: 446–452.
-
19.
Bodur H , Erbay A , Akinci E , Colpan A , Cevik MA , Balaban N , 2003. Neurobrucellosis in an endemic area of brucellosis. Scand J Infect Dis 35: 94–97.
-
20.
Pascual J , Combarros O , Polo JM , Berciano J , 1988. Localized CNS brucellosis: Report of 7 cases. Acta Neurol Scand 78: 282–289.
-
21.
Kaygusuz TO , Kaygusuz I , Kilic SS , Yalcin S , Felek S , 2005. Investigation of hearing loss in patients with acute brucellosis by standard and high-frequency audiometry. Clin Microbiol Infect 11: 559–563.
-
22.
Diaz Espejo CE , Chaves FV , Ramis BS , 1987. Chronic intracranial hypertension secondary to neurobrucellosis. J Neurol 234: 59–61.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3887 | 3887 | 188 |
| Full Text Views | 46 | 46 | 4 |
| PDF Downloads | 73 | 73 | 8 |
Case Report: Brucellosis Mimicking Tuberculous Meningitis in a Child
Sevgi Aslan Tuncay
Sevgi Aslan Tuncay
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Sevgi Aslan Tuncay in
Current site
Google Scholar
PubMed
Search for other papers by Sevgi Aslan Tuncay in
Current site
Google Scholar
PubMed
Gulsen Akkoc
Gulsen Akkoc
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Gulsen Akkoc in
Current site
Google Scholar
PubMed
Search for other papers by Gulsen Akkoc in
Current site
Google Scholar
PubMed
Seyhan Yilmaz
Seyhan Yilmaz
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Seyhan Yilmaz in
Current site
Google Scholar
PubMed
Search for other papers by Seyhan Yilmaz in
Current site
Google Scholar
PubMed
Burcu Parlak
Burcu Parlak
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Burcu Parlak in
Current site
Google Scholar
PubMed
Search for other papers by Burcu Parlak in
Current site
Google Scholar
PubMed
Pinar Canizci Erdemli
Pinar Canizci Erdemli
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Pinar Canizci Erdemli in
Current site
Google Scholar
PubMed
Search for other papers by Pinar Canizci Erdemli in
Current site
Google Scholar
PubMed
Aylin Dizi Isik
Aylin Dizi Isik
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Aylin Dizi Isik in
Current site
Google Scholar
PubMed
Search for other papers by Aylin Dizi Isik in
Current site
Google Scholar
PubMed
Eda Kepenekli
ekepenekli@yahoo.com
Eda Kepenekli
Marmara University School of Medicine, Department of Pediatric Infectious Diseases, Istanbul, Turkey
Search for other papers by Eda Kepenekli in
Current site
Google Scholar
PubMed
Search for other papers by Eda Kepenekli in
Current site
Google Scholar
PubMed
ABSTRACT.
Neurobrucellosis is rare in children, presenting with a variety of clinical manifestations, including meningitis, meningoencephalitis, cranial neuropathies, and intracranial mass-like lesions. We present a case of a 17-year-old girl admitted to the hospital in Istanbul for headache. Lumbar puncture showed elevated intracranial pressure, monocytic pleocytosis, elevated total protein, and hypoglycorrhachia. Brucella melitensis grew from the cerebrospinal fluid. The patient was treated with doxycycline, rifampin, amikacin, and ceftriaxone and showed persistent sensorineural hearing loss. It is essential to consider brucellosis in the differential diagnosis of infectious neurological disease in areas where the disease is endemic. Serologic tests and cultures are needed for diagnosis, and efforts need to be made to identify the infecting organism to the species level to guide zoonotic source control efforts.
Author Notes
Current contact information: Sevgi Aslan Tuncay, Gülşen Akkoç, Seyhan Yılmaz, Burcu Parlak, Pınar Canizci Erdemli, and Aylin Dizi Işık, Marmara University Faculty of Medicine, Department of Pediatric Infectious Disease, Istanbul, Turkey, E-mails: aslan.svgi@gmail.com, agulsenakkoc@gmail.com, seyhanbirinci@gmail.com, drbparlak47@gmail.com, pinarcanizci@hotmail.com, and aylindizi_91@hotmail.com. Eda Kepenekli, Bahcesehir University, Medical Park Goztepe Hospital, Department of Pediatric Infectious Diseases, Istanbul, Turkey, E-mail: ekepenekli@yahoo.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Oz FN , Tanir G , Simsek G , Kaya NG , Akin I , 2013. A case of underdiagnosed Brucella meningitis presented with hearing loss. Infect Dis Clin Pract 21: 136–138.
-
2.
Bricker BJ , Ewalt DR , Halling SM , 2003. Brucella ‘HOOF-Prints’: strain typing by multi-locus analysis of variable number tandem repeats (VNTRs). BMC Microbiol 3: 15.
-
3.
American Academy of Pediatrics , 2021. Red Book: 2021–2024 Report of the Committee on Infectious Diseases. Itasca, IL; American Academy of Pediatrics.
-
4.
Gul HC , Erdem H , Bek S , 2009. Overview of neurobrucellosis: A pooled analysis of 187 cases. Int J Infect Dis 13: 339–343.
-
5.
Akdeniz H , Irmak H , Anlar O , Demiroz AP , 1998. Central nervous system brucellosis: Presentation, diagnosis and treatment. J Infect 36: 297–301.
-
6.
Qasim SS , Baharoon S , Layqah L , 2021. A case of seronegative pediatric neurobrucellosis presenting with ataxia. Cureus 13: e12540.
-
7.
Sanchez-Sousa A , Torres C , Campello MG , Garcia C , Parras F , Cercenado E , Baquero F , 1990. Serological diagnosis of neurobrucellosis. J Clin Pathol 43: 79–81.
-
8.
Araj GF , Lulu AR , Saadah MA , Mousa AM , Strannegard IL , Shakir RA , 1986. Rapid diagnosis of central nervous system brucellosis by ELISA. J Neuroimmunol 12: 173–182.
-
9.
Guven T , Ugurlu K , Ergonul O , Celikbas AK , Gok SE , Comoglu S , Baykam N , Dokuzoguz B , 2013. Neurobrucellosis: Clinical and diagnostic features. Clin Infect Dis 56: 1407–1412.
-
10.
Al-Sous MW , Bohlega S , Al-Kawi MZ , Alwatban J , McLean DR , 2004. Neurobrucellosis: Clinical and neuroimaging correlation. AJNR Am J Neuroradiol 25: 395–401.
-
11.
Mousa AR , Koshy TS , Araj GF , Marafie AA , Muhtaseb SA , Al-Mudallal DS , Busharetulla MS , 1986. Brucella meningitis: Presentation, diagnosis and treatment—a prospective study of ten cases. Q J Med 60: 873–885.
-
12.
CDC , 2010. Brucellosis (Brucella spp.). 2010 Case Definition. Available at: https://ndc.services.cdc.gov/case-definitions/brucellosis-2010/. Accessed September 19, 2023.
-
13.
Al-Tawfiq JA , 2008. Therapeutic options for human brucellosis. Expert Rev Anti Infect Ther 6: 109–120.
-
14.
Young EJ , 1995. An overview of human brucellosis. Clin Infect Dis 21: 283–290.
-
15.
Alp E , Doğanay M , Willke Topçu A , Söyletir G & Doğanay M Infectious Diseases and Microbiology, 4th edition. Istanbul, Turkey: Nobel Medical Bookstores, 1827–1834.
-
16.
Akcam FZ , Akcam M , Yilmaz M , Temei E , 2020. Neurobrucellosis: Two cases, two different presentation. Turk J Neurol. 26: 342–345.
-
17.
Erdem H et al., 2012. Efficacy and tolerability of antibiotic combinations in neurobrucellosis: Results of the Istanbul study. Antimicrob Agents Chemother 56: 1523–1528.
-
18.
Yetkin MA , Bulut C , Erdinc FS , Oral B , Tulek N , 2006. Evaluation of the clinical presentations in neurobrucellosis. Int J Infect Dis 10: 446–452.
-
19.
Bodur H , Erbay A , Akinci E , Colpan A , Cevik MA , Balaban N , 2003. Neurobrucellosis in an endemic area of brucellosis. Scand J Infect Dis 35: 94–97.
-
20.
Pascual J , Combarros O , Polo JM , Berciano J , 1988. Localized CNS brucellosis: Report of 7 cases. Acta Neurol Scand 78: 282–289.
-
21.
Kaygusuz TO , Kaygusuz I , Kilic SS , Yalcin S , Felek S , 2005. Investigation of hearing loss in patients with acute brucellosis by standard and high-frequency audiometry. Clin Microbiol Infect 11: 559–563.
-
22.
Diaz Espejo CE , Chaves FV , Ramis BS , 1987. Chronic intracranial hypertension secondary to neurobrucellosis. J Neurol 234: 59–61.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3887 | 3887 | 188 |
| Full Text Views | 46 | 46 | 4 |
| PDF Downloads | 73 | 73 | 8 |