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Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia

Ayzsa Tannis National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;
Eagle Global Scientific, LLC, San Antonio, Texas;

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Suzanne Newton National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Angelica Rico Division of Research in Public Health, National Institute of Health, Bogota, Colombia;

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Maritza Gonzalez Division of Research in Public Health, National Institute of Health, Bogota, Colombia;

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Monica Benavides Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;

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Jessica N. Ricaldi National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Helena Rodriguez Division of Research in Public Health, National Institute of Health, Bogota, Colombia;

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Laura D. Zambrano National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Marcela Daza Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;

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Shana Godfred-Cato National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Jennifer D. Thomas National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Jacqueline Acosta Research Division, Vysnova Partners, Bethesda, Maryland;

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Panagiotis Maniatis National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Jonathan B. Daniels Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Veronica Burkel National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;
Eagle Global Scientific, LLC, San Antonio, Texas;

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Elizabeth C. Ailes National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Diana Valencia National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Suzanne M. Gilboa National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Denise J. Jamieson Carver College of Medicine, University of Iowa, Iowa City, Iowa;

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Marcela Mercado Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;

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Julie M. Villanueva National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Margaret A. Honein National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

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Martha L. Ospina Global Health Department, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida;
Department of Health Sciences, Simon Boliviar University, Bogota, Colombia

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Van T. Tong National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;

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DOI:
https://doi.org/10.4269/ajtmh.23-0873
Volume/Issue:
Volume 111: Issue 3
Page(s):
622–626
Restricted access
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ABSTRACT.

Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (n = 1,519) during February 2017–September 2018 and their infants (n = 1,080) during June 2017–March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3–7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7–2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.

    • Supplemental Materials (PDF 495.98 KB)

Author Notes

Financial support: This research was made possible through support provided by the CDC, the INS, and the Office of Infectious Disease, Bureau for Global Health, USAID under the terms of an Interagency Agreement with the CDC. A Memorandum of Understanding between the CDC and the INS was signed in August 2016 to support areas of collaboration including public health surveillance, epidemiology, laboratory screening and diagnosis, vector control, and other public health response activities for the ZIKV outbreak. The work was implemented through contract numbers 200-2016-91589 and 200-2017-95780 to Vysnova Partners, Inc.

Current contact information: Ayzsa Tannis, Centers for Disease Control and Prevention, Atlanta, GA, and Eagle Global Scientific, LLC, San Antonio, TX, E-mail: qpc5@cdc.gov. Suzanne Newton, Jessica N. Ricaldi, Laura D. Zambrano, Shana Godfred-Cato, Jennifer D. Thomas, Panagiotis Maniatis, Jonathan B. Daniels, Veronica Burkel, Elizabeth C. Ailes, Diana Valencia, Suzanne M. Gilboa, Julie M. Villanueva, Margaret A. Honein, and Van T. Tong, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: ogc4@cdc.gov, mpi7@cdc.gov, xbs6@cdc.gov, nzt6@cdc.gov, fsu8@cdc.gov, vhd2@cdc.gov, yer1@cdc.gov, xee5@cdc.gov, eha0@cdc.gov, ile9@cdc.gov, suz0@cdc.gov, julie.villanueva@hhs.gov, mrh7@cdc.gov, and vct2@cdc.gov. Angelica Rico, Maritza Gonzalez, Monica Benavides, Marcela Daza, and Marcela Mercado, National Institute of Health, Bogota, Colombia, E-mails: arico@ins.gov.co, magonzalez@ins.gov.co, mbenavides@ins.gov.co, madazaca@unal.edu.co, and mercado.marcela10@gmail.com. Helena Rodriguez, Chancellery, Bogota, Colombia, E-mail: helenamrp17@gmail.com. Jacqueline Acosta, Vysnova Partners, Bethesda, MD, E-mail: jadfaesp@yahoo.es. Denise J. Jamieson, University of Iowa, Iowa City, IA, E-mail: djjamieson@uiowa.edu. Martha L. Ospina, Florida International University, Miami, FL, and Simon Boliviar University, Bogota, Colombia, E-mail: ospina.ml@gmail.com.

Address correspondence to Ayzsa Tannis, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341. E-mail: setnet@cdc.gov
Copyright:
© American Society of Tropical Medicine and Hygiene 2024
Received:
07 Dec 2023
|
Accepted:
29 Mar 2024
|
Published Online:
09 Jul 2024
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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