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1.
Özdem S , Tanır G , Öz FN , Yalçınkaya R , Cinni RG , Savaş Şen Z , Nur Aydin N , Kaman A , Polat M , Aydin Teke T , 2022. Bacteremic and nonbacteremic brucellosis in children in Turkey. J Trop Pediatr 68: fmab114.
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2.
Pappas G , Papadimitriou P , Akritidis N , Christou L , Tsianos EV , 2006. The new global map of human brucellosis. Lancet Infect Dis 6: 91–99.
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3.
Bosilkovski M , Dimzova M , Grozdanovski K , 2009. Natural history of brucellosis in an endemic region in different time periods. Acta Clin Croat 48: 41–46.
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4.
Çiftdoğan DY , Aslan S , 2020. Osteoarticular involvement of brucellosis in pediatric patients: Clinical and laboratory characteristics. Turk J Pediatr 62: 199–207.
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5.
Justman N , Fruchtman Y , Greenberg D , Ben-Shimol S , 2018. Hematologic manifestations of brucellosis in children. Pediatr Infect Dis J 37: 586–591.
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6.
Qasim SS , Alshuwaier K , Alosaimi MQ , Alghafees MA , Alrasheed A , Layqah L , Baharoon S , 2020. Brucellosis in Saudi children: Presentation, complications, and treatment outcome. Cureus 12: e11289.
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7.
Corbel MJ, 2006. Food and Agriculture Organization of the United Nations, World Health Organization & World Organisation for Animal Health. Brucellosis in Humans and Animals. World Health Organization. Available at: https://iris.who.int/handle/10665/43597. Accessed April 8, 2024.
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Varikkodan I , Naushad VA , Purayil NK , Mathew J , Alrawi FM , 2021. Complicated brucellosis with multisystem involvement: Two case reports. Cureus 13: e15950.
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Ma L , Ma J , Chen X , Dong L , 2021. A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults. J Infect Dev Ctries 15: 1147–1154.
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Woods CR et al., 2021. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Pediatric Infect Dis Soc 10: 801–844.
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11.
Gür A , Geyik MF , Dikici B , Nas K , Cevik R , Sarac J , Hosoglu S , 2003. Complications of brucellosis in different age groups: A study of 283 cases in southeastern Anatolia of Turkey. Yonsei Med J 44: 33–44.
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12.
Al Dahouk S , Tomaso H , Nöckler K , Neubauer H , Frangoulidis D , 2003. Laboratory-based diagnosis of brucellosis–a review of the literature. Part II: Serological tests for brucellosis. Clin Lab 49: 577–589.
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13.
Demirdal T , Sen P , 2020. Risk factors for focal involvement in brucellosis. Diagn Microbiol Infect Dis 97: 115003.
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14.
Çiftdoğan DY , Aslan S , 2017. Unrecognized pediatric and adult family members of children with acute brucellosis. Braz J Infect Dis 21: 520–524.
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Bosilkovski M , Kirova-Urosevic V , Cekovska Z , Labacevski N , Cvetanovska M , Rangelov G , Cana F , Bogoeva-Tasevska S , 2013. Osteoarticular involvement in childhood brucellosis: Experience with 133 cases in an endemic region. Pediatr Infect Dis J 32: 815–819.
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Karli A , Sensoy G , Albayrak C , Koken O , Cirakli S , Belet N , Albayrak D , 2015. Pancytopenia as the initial manifestation of brucellosis in children. Vector Borne Zoonotic Dis 15: 545–549.
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Colmenero JD , Ruiz-Mesa JD , Plata A , Bermúdez P , Martín-Rico P , Queipo-Ortuño MI , Reguera JM , 2008. Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis. Clin Infect Dis 46: 426–433.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1269 | 1269 | 270 |
| Full Text Views | 41 | 41 | 7 |
| PDF Downloads | 54 | 54 | 13 |
Comparative Analysis of Pediatric Patients with Different Involvements of Brucellosis
Melis Deniz
Melis Deniz
Department of Pediatric Infectious Diseases, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey;
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Hande Şenol
Hande Şenol
Department of Biostatistics, Pamukkale University, Denizli, Turkey;
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Kerim Parlak
Kerim Parlak
Department of Microbiology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey;
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Feyza Kabar
Feyza Kabar
Department of Pediatric Radiology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey
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ABSTRACT.
Brucellosis is a zoonotic disease that mimics many other diseases, making diagnosis difficult in pediatric patients. If the clinical signs of the disease are not well known and there is a delay in diagnosis and treatment, complicated brucellosis involving different body sites can develop. This study aimed to analyze the demographics, clinical information, laboratory test results, and imaging findings of children with brucellosis. Particular attention was paid to the involvement of organs and potential complications. Pediatric patients diagnosed with brucellosis at the Sanlıurfa Training and Research Hospital in Turkey were retrospectively evaluated. In total, 101 patients diagnosed with brucellosis were included in this study. Bone-joint involvement was observed in 21 (20.7%) patients. High Brucella Coombs gel test (CT) titers (≥1/640) and increased erythrocyte sedimentation rate (ESR) were significant in the bone-joint brucellosis group (P = 0.022 and P = 0.0205, respectively). Fourteen (13.9%) patients had at least one organomegaly in which Brucella CT titers and C-reactive protein (CRP) levels were substantially higher than those in patients without organomegaly (P = 0.02 and P = 0.0049, respectively). Anemia, leukopenia, and thrombocytopenia were observed in 36 (35.6%), 10 (9.9%), and 4 (3.9%) patients, respectively. At least one elevation in liver function test (LFT) results was observed in 32 (31.7%) patients. High acute-phase reactants, such as ESR, CRP levels, and Brucella CT titers, may help identify complicated brucellosis. This study highlights that pediatric brucellosis can lead to cytopenia and elevated LFT results and should therefore be considered as a differential diagnosis.
Author Notes
Current contact information: Melis Deniz, Department of Pediatric Infectious Diseases, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey, E-mail: mlsdnz@gmail.com. Hande Şenol, Department of Biostatistics, Pamukkale University, Denizli, Turkey, E-mail: handesenol@gmail.com. Kerim Parlak, Department of Microbiology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey, E-mail: kerimparlak1@gmail.com. Feyza Kabar, Department of Pediatric Radiology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey, E-mail: feyzakabar@uludag.edu.tr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Özdem S , Tanır G , Öz FN , Yalçınkaya R , Cinni RG , Savaş Şen Z , Nur Aydin N , Kaman A , Polat M , Aydin Teke T , 2022. Bacteremic and nonbacteremic brucellosis in children in Turkey. J Trop Pediatr 68: fmab114.
-
2.
Pappas G , Papadimitriou P , Akritidis N , Christou L , Tsianos EV , 2006. The new global map of human brucellosis. Lancet Infect Dis 6: 91–99.
-
3.
Bosilkovski M , Dimzova M , Grozdanovski K , 2009. Natural history of brucellosis in an endemic region in different time periods. Acta Clin Croat 48: 41–46.
-
4.
Çiftdoğan DY , Aslan S , 2020. Osteoarticular involvement of brucellosis in pediatric patients: Clinical and laboratory characteristics. Turk J Pediatr 62: 199–207.
-
5.
Justman N , Fruchtman Y , Greenberg D , Ben-Shimol S , 2018. Hematologic manifestations of brucellosis in children. Pediatr Infect Dis J 37: 586–591.
-
6.
Qasim SS , Alshuwaier K , Alosaimi MQ , Alghafees MA , Alrasheed A , Layqah L , Baharoon S , 2020. Brucellosis in Saudi children: Presentation, complications, and treatment outcome. Cureus 12: e11289.
-
7.
Corbel MJ, 2006. Food and Agriculture Organization of the United Nations, World Health Organization & World Organisation for Animal Health. Brucellosis in Humans and Animals. World Health Organization. Available at: https://iris.who.int/handle/10665/43597. Accessed April 8, 2024.
-
8.
Varikkodan I , Naushad VA , Purayil NK , Mathew J , Alrawi FM , 2021. Complicated brucellosis with multisystem involvement: Two case reports. Cureus 13: e15950.
-
9.
Ma L , Ma J , Chen X , Dong L , 2021. A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults. J Infect Dev Ctries 15: 1147–1154.
-
10.
Woods CR et al., 2021. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Pediatric Infect Dis Soc 10: 801–844.
-
11.
Gür A , Geyik MF , Dikici B , Nas K , Cevik R , Sarac J , Hosoglu S , 2003. Complications of brucellosis in different age groups: A study of 283 cases in southeastern Anatolia of Turkey. Yonsei Med J 44: 33–44.
-
12.
Al Dahouk S , Tomaso H , Nöckler K , Neubauer H , Frangoulidis D , 2003. Laboratory-based diagnosis of brucellosis–a review of the literature. Part II: Serological tests for brucellosis. Clin Lab 49: 577–589.
-
13.
Demirdal T , Sen P , 2020. Risk factors for focal involvement in brucellosis. Diagn Microbiol Infect Dis 97: 115003.
-
14.
Çiftdoğan DY , Aslan S , 2017. Unrecognized pediatric and adult family members of children with acute brucellosis. Braz J Infect Dis 21: 520–524.
-
15.
Bosilkovski M , Kirova-Urosevic V , Cekovska Z , Labacevski N , Cvetanovska M , Rangelov G , Cana F , Bogoeva-Tasevska S , 2013. Osteoarticular involvement in childhood brucellosis: Experience with 133 cases in an endemic region. Pediatr Infect Dis J 32: 815–819.
-
16.
Karli A , Sensoy G , Albayrak C , Koken O , Cirakli S , Belet N , Albayrak D , 2015. Pancytopenia as the initial manifestation of brucellosis in children. Vector Borne Zoonotic Dis 15: 545–549.
-
17.
Young EJ , Long SS , Prober CG & Fischer M Principles and Practice of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: Elsevier, 4562–4566.
-
18.
Colmenero JD , Ruiz-Mesa JD , Plata A , Bermúdez P , Martín-Rico P , Queipo-Ortuño MI , Reguera JM , 2008. Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis. Clin Infect Dis 46: 426–433.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1269 | 1269 | 270 |
| Full Text Views | 41 | 41 | 7 |
| PDF Downloads | 54 | 54 | 13 |