ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Bach E , Sant’Anna FH , Magrich Dos Passos JF , Balsanelli E , de Baura VA , Pedrosa FO , de Souza EM , Passaglia LMP , 2017. Detection of misidentifications of species from the Burkholderia cepacia complex and description of a new member, the soil bacterium Burkholderia catarinensis sp. nov. Pathog Dis 75: 1–22.
-
2.
Vermis K , Coenye T , Mahenthiralingam E , Nelis HJ , Vandamme P , 2002. Evaluation of species-specific recA-based PCR tests for genomovar level identification within the Burkholderia cepacia complex. J Med Microbiol 51: 937–940.
-
3.
Sfeir MM , 2018. Burkholderia cepacia complex infections: More complex than the bacterium name suggests. J Infect 77: 166–170.
-
4.
Abe K , D’Angelo MT , Sunenshine R , Noble-Wang J , Cope J , Jensen B , Srinivasan A , 2007. Outbreak of Burkholderia cepacia bloodstream infection at an outpatient hematology and oncology practice. Infect Control Hosp Epidemiol 28: 1311–1313.
-
5.
Drevinek P , Mahenthiralingam E , 2010. Burkholderia cenocepacia in cystic fibrosis: Epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect 16: 821–830.
-
6.
Liao CH , Chang HT , Lai CC , Huang YT , Hsu MS , Liu CY , Yang CJ , Hsueh PR , 2011. Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. Diagn Microbiol Infect Dis 70: 260–266.
-
7.
Pegues CF , Pegues DA , Ford DS , Hibberd PL , Carson LA , Raine CM , Hooper DC , 1996. Burkholderia cepacia respiratory tract acquisition: Epidemiology and molecular characterization of a large nosocomial outbreak. Epidemiol Infect 116: 309–317.
-
8.
El Chakhtoura NG , Saade E , Wilson BM , Perez F , Papp-Wallace KM , Bonomo RA , 2017. A 17-year nationwide study of Burkholderia cepacia complex bloodstream infections among patients in the United States Veterans Health Administration. Clin Infect Dis 65: 1327–1334.
-
9.
Hobson R , Gould I , Govan J , 1995. Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. Eur J Clin Microbiol Infect Dis 14: 908–911.
-
10.
Yıldız B , Duyu M , Sözeri B , Karapınar B , 2012. Soft tissue infection caused by Burkholderia cepacia in a child with polyarteritis nodosa. Turk J Pediatr 54: 664–666.
-
11.
Bedir Demirdag T , Ozkaya Parlakay A , Aygar IS , Gulhan B , Kanik Yuksek S , 2020. Major aspects of Burkholderia gladioli and Burkholderia cepacia infections in children. Pediatr Infect Dis J 39: 374–378.
-
12.
Patra S , Bhat YR , Lewis LE , Purakayastha J , Sivaramaraju VV , Kalwaje EV , Mishra S , 2014. Burkholderia cepacia sepsis among neonates. Indian J Pediatr 81: 1233–1236.
-
13.
Zurita J , Mejia L , Zapata S , Trueba G , Vargas AC , Aguirre S , Falconi G , 2014. Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash. Int J Infect Dis 29: 96–99.
-
14.
Song JE , Kwak YG , Um TH , Cho CR , Kim S , Park IS , Hwang JH , Kim N , Oh GB , 2018. Outbreak of Burkholderia cepacia pseudobacteraemia caused by intrinsically contaminated commercial 0.5% chlorhexidine solution in neonatal intensive care units. J Hosp Infect 98: 295–299.
-
15.
Magalhães M , Doherty C , Govan JRW , Vandamme P , 2003. Polyclonal outbreak of Burkholderia cepacia complex bacteraemia in haemodialysis patients. J Hosp Infect 54: 120–123.
-
16.
Gilbert DN , Moellering RC Jr. , Eliopoulos GM , Chambers HF , Saag MS , 2010. The Sanford Guide to Antimicrobial Therapy. 40th ed. Sperryville, VA: Antimicrobial Therapy, Inc.
-
17.
Rhodes KA , Schweizer HP , 2016. Antibiotic resistance in Burkholderia species. Drug Resist Updat 28: 82–90.
-
18.
Coenye T , 2010. Social interactions in the Burkholderia cepacia complex: Biofilms and quorum sensing. Future Microbiol 5: 1087–1099.
-
19.
Siddiqui T , Sahu C , Patel SS , Ghoshal U , 2022. Clinical and microbiological profile of patients with bloodstream infections caused by Burkholderia cepacia complex. J Lab Physicians 14: 312–316.
-
20.
Shi H , Chen X , Chen L , Zhu B , Yan W , Ma X , 2023. Burkholderia cepacia infection in children without cystic fibrosis: A clinical analysis of 50 cases. Front Pediatr 11: 1115877.
-
21.
Folescu TW , da Costa CH , Cohen RW , Neto OC , Albano RM , Marques EA , 2015. Burkholderia cepacia complex: Clinical course in cystic fibrosis patients. BMC Pulm Med 15: 1–6.
-
22.
Heo ST , Kim SJ , Jeong YG , Bae IG , Jin JS , Lee JC , 2008. Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters. J Hosp Infect 70: 241–245.
-
23.
Jia Y , Liu Y , Liu Y , Yang K , Liu Y , 2022. Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients. BMC Infect Dis 22: 1–9.
-
24.
Kandemir O , Erbey F , Asarcıklı F , Sözmen BO , Özen MA , Aktürk H , 2022. Catheter-related bloodstream infection caused by Burkholderia cepacia in a pediatric oncology patient. Germs 12: 316.
-
25.
Ku NS , Han SH , Kim CO , Baek JH , Jeong SJ , Jin SJ , Choi JY , Song YG , Kim JM , 2011. Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. Scand J Infect Dis 43: 792–797.
-
26.
Huang CH , Jang TN , Liu CY , Fung CP , Yu KW , Wong WW , 2001. Characteristics of patients with Burkholderia cepacia bacteremia. J Microbiol Immunol Infect 34: 215–219.
-
27.
Souza AV et al., 2004. Characterizing uncommon Burkholderia cepacia complex isolates from an outbreak in a haemodialysis unit. J Med Microbiol 53: 999–1005.
-
28.
Rastogi N et al., 2019. Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit. Int J Infect Dis 79: 4–11.
-
29.
Righi E et al., 2013. Characteristics and outcome predictors of patients involved in an outbreak of Burkholderia cepacia complex. J Hosp Infect 85: 73–75.
-
30.
El Chakhtoura NG , Saade E , Wilson BM , Perez F , Papp-Wallace KM , Bonomo RA , 2017. A 17-year nationwide study of Burkholderia cepacia complex bloodstream infections among patients in the United States Veterans Health Administration. Clin Infect Dis 65: 1327–1334.
-
31.
Chang TH , Chuang YC , Wang JT , Sheng WH , 2021. Clinical characteristics and outcomes of non-cystic fibrosis patients with Burkholderia cepacia complex bacteremia at a medical center in Taiwan. J Microbiol Immunol Infect 55: 1301–1309.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 849 | 849 | 180 |
| Full Text Views | 26 | 26 | 3 |
| PDF Downloads | 34 | 34 | 3 |
Epidemiology and Clinical Features of Burkholderia Bacteremia at a Hospital in India
Mitra Kar
Mitra Kar
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Mitra Kar in
Current site
Google Scholar
PubMed
Search for other papers by Mitra Kar in
Current site
Google Scholar
PubMed
Nidhi Tejan
Nidhi Tejan
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Nidhi Tejan in
Current site
Google Scholar
PubMed
Search for other papers by Nidhi Tejan in
Current site
Google Scholar
PubMed
Ashima Jamwal
Ashima Jamwal
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Ashima Jamwal in
Current site
Google Scholar
PubMed
Search for other papers by Ashima Jamwal in
Current site
Google Scholar
PubMed
Akanksha Dubey
Akanksha Dubey
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Akanksha Dubey in
Current site
Google Scholar
PubMed
Search for other papers by Akanksha Dubey in
Current site
Google Scholar
PubMed
Romya Singh
Romya Singh
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Romya Singh in
Current site
Google Scholar
PubMed
Search for other papers by Romya Singh in
Current site
Google Scholar
PubMed
Chinmoy Sahu
Chinmoy Sahu
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Chinmoy Sahu in
Current site
Google Scholar
PubMed
Search for other papers by Chinmoy Sahu in
Current site
Google Scholar
PubMed
Sangram Singh Patel
Sangram Singh Patel
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Sangram Singh Patel in
Current site
Google Scholar
PubMed
Search for other papers by Sangram Singh Patel in
Current site
Google Scholar
PubMed
Pooja Kumari
Pooja Kumari
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Pooja Kumari in
Current site
Google Scholar
PubMed
Search for other papers by Pooja Kumari in
Current site
Google Scholar
PubMed
Malay Ghar
Malay Ghar
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for other papers by Malay Ghar in
Current site
Google Scholar
PubMed
Search for other papers by Malay Ghar in
Current site
Google Scholar
PubMed
ABSTRACT.
Burkholderia spp. are opportunistic pathogens that cause infection in patients with disrupted immunity. The study intended to demonstrate the epidemiology and clinical features associated with Burkholderia spp. bacteremia. This retrospective study was performed to assess the clinical and laboratory characteristics of patients whose blood cultures were growing Burkholderia spp. and, based on their underlying comorbidities, were subjected to survival analysis from January 2022 to December 2022 at a university hospital in northern India. Three hundred patients with Burkholderia spp. bacteremia were included in this study conducted over 1 year. The mean age of the patients was 33.86 years with a male predominance of 56.67% (170/300, 56.67%). Underlying malignancies (207/300, 69.0%) were the most common clinical diagnosis, and catheter in situ (300/300, 100.0%) was the most common risk factor. Burkholderia cenocepacia (244/300, 81.33%) was the most common Burkholderia spp. isolated. All isolates were highly susceptible to minocycline. Kidney disease (P = 0.029), hypertension (P = 0.005), type 2 diabetes mellitus (P = 0.039), and respiratory disease (P <0.001) in patients were significantly associated with death owing to Burkholderia spp. bacteremia, whereas patients with malignancies (P <0.001) and undergoing treatment were significantly associated with a better outcome when the microorganism was susceptible to empirical antibiotics. The presence of indwelling devices, mechanical ventilation (P <0.001), and a hemodialysis catheter (P = 0.026) were statistically significant risk factors associated with poor outcomes.
Author Notes
Disclosures: All authors read and approved the final version of the manuscript. Ethical approval was received from the Institute Ethics Committee (2021-52-EMP-EXP Dated 13/04/21). All individuals provided consent to participate in the study. No supporting data in publicly available repositories (where available and appropriate) were added to the main work.
Current contact information: Mitra Kar, Nidhi Tejan, Ashima Jamwal, Akanksha Dubey, Romya Singh, Chinmoy Sahu, Sangram Singh Patel, Pooja Kumari, and Malay Ghar, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, E-mails: mitrakar25@gmail.com, drnidhitejan@gmail.com, ashi.jamwal@gmail.com, akanksha.dubey232@gmail.com, singh.romya3010@gmail.com, sahu.chinmoy@gmail.com, sangramsgpgi@gmail.com, poojaavni395@gmail.com, and malayghar@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Bach E , Sant’Anna FH , Magrich Dos Passos JF , Balsanelli E , de Baura VA , Pedrosa FO , de Souza EM , Passaglia LMP , 2017. Detection of misidentifications of species from the Burkholderia cepacia complex and description of a new member, the soil bacterium Burkholderia catarinensis sp. nov. Pathog Dis 75: 1–22.
-
2.
Vermis K , Coenye T , Mahenthiralingam E , Nelis HJ , Vandamme P , 2002. Evaluation of species-specific recA-based PCR tests for genomovar level identification within the Burkholderia cepacia complex. J Med Microbiol 51: 937–940.
-
3.
Sfeir MM , 2018. Burkholderia cepacia complex infections: More complex than the bacterium name suggests. J Infect 77: 166–170.
-
4.
Abe K , D’Angelo MT , Sunenshine R , Noble-Wang J , Cope J , Jensen B , Srinivasan A , 2007. Outbreak of Burkholderia cepacia bloodstream infection at an outpatient hematology and oncology practice. Infect Control Hosp Epidemiol 28: 1311–1313.
-
5.
Drevinek P , Mahenthiralingam E , 2010. Burkholderia cenocepacia in cystic fibrosis: Epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect 16: 821–830.
-
6.
Liao CH , Chang HT , Lai CC , Huang YT , Hsu MS , Liu CY , Yang CJ , Hsueh PR , 2011. Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. Diagn Microbiol Infect Dis 70: 260–266.
-
7.
Pegues CF , Pegues DA , Ford DS , Hibberd PL , Carson LA , Raine CM , Hooper DC , 1996. Burkholderia cepacia respiratory tract acquisition: Epidemiology and molecular characterization of a large nosocomial outbreak. Epidemiol Infect 116: 309–317.
-
8.
El Chakhtoura NG , Saade E , Wilson BM , Perez F , Papp-Wallace KM , Bonomo RA , 2017. A 17-year nationwide study of Burkholderia cepacia complex bloodstream infections among patients in the United States Veterans Health Administration. Clin Infect Dis 65: 1327–1334.
-
9.
Hobson R , Gould I , Govan J , 1995. Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. Eur J Clin Microbiol Infect Dis 14: 908–911.
-
10.
Yıldız B , Duyu M , Sözeri B , Karapınar B , 2012. Soft tissue infection caused by Burkholderia cepacia in a child with polyarteritis nodosa. Turk J Pediatr 54: 664–666.
-
11.
Bedir Demirdag T , Ozkaya Parlakay A , Aygar IS , Gulhan B , Kanik Yuksek S , 2020. Major aspects of Burkholderia gladioli and Burkholderia cepacia infections in children. Pediatr Infect Dis J 39: 374–378.
-
12.
Patra S , Bhat YR , Lewis LE , Purakayastha J , Sivaramaraju VV , Kalwaje EV , Mishra S , 2014. Burkholderia cepacia sepsis among neonates. Indian J Pediatr 81: 1233–1236.
-
13.
Zurita J , Mejia L , Zapata S , Trueba G , Vargas AC , Aguirre S , Falconi G , 2014. Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash. Int J Infect Dis 29: 96–99.
-
14.
Song JE , Kwak YG , Um TH , Cho CR , Kim S , Park IS , Hwang JH , Kim N , Oh GB , 2018. Outbreak of Burkholderia cepacia pseudobacteraemia caused by intrinsically contaminated commercial 0.5% chlorhexidine solution in neonatal intensive care units. J Hosp Infect 98: 295–299.
-
15.
Magalhães M , Doherty C , Govan JRW , Vandamme P , 2003. Polyclonal outbreak of Burkholderia cepacia complex bacteraemia in haemodialysis patients. J Hosp Infect 54: 120–123.
-
16.
Gilbert DN , Moellering RC Jr. , Eliopoulos GM , Chambers HF , Saag MS , 2010. The Sanford Guide to Antimicrobial Therapy. 40th ed. Sperryville, VA: Antimicrobial Therapy, Inc.
-
17.
Rhodes KA , Schweizer HP , 2016. Antibiotic resistance in Burkholderia species. Drug Resist Updat 28: 82–90.
-
18.
Coenye T , 2010. Social interactions in the Burkholderia cepacia complex: Biofilms and quorum sensing. Future Microbiol 5: 1087–1099.
-
19.
Siddiqui T , Sahu C , Patel SS , Ghoshal U , 2022. Clinical and microbiological profile of patients with bloodstream infections caused by Burkholderia cepacia complex. J Lab Physicians 14: 312–316.
-
20.
Shi H , Chen X , Chen L , Zhu B , Yan W , Ma X , 2023. Burkholderia cepacia infection in children without cystic fibrosis: A clinical analysis of 50 cases. Front Pediatr 11: 1115877.
-
21.
Folescu TW , da Costa CH , Cohen RW , Neto OC , Albano RM , Marques EA , 2015. Burkholderia cepacia complex: Clinical course in cystic fibrosis patients. BMC Pulm Med 15: 1–6.
-
22.
Heo ST , Kim SJ , Jeong YG , Bae IG , Jin JS , Lee JC , 2008. Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters. J Hosp Infect 70: 241–245.
-
23.
Jia Y , Liu Y , Liu Y , Yang K , Liu Y , 2022. Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients. BMC Infect Dis 22: 1–9.
-
24.
Kandemir O , Erbey F , Asarcıklı F , Sözmen BO , Özen MA , Aktürk H , 2022. Catheter-related bloodstream infection caused by Burkholderia cepacia in a pediatric oncology patient. Germs 12: 316.
-
25.
Ku NS , Han SH , Kim CO , Baek JH , Jeong SJ , Jin SJ , Choi JY , Song YG , Kim JM , 2011. Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. Scand J Infect Dis 43: 792–797.
-
26.
Huang CH , Jang TN , Liu CY , Fung CP , Yu KW , Wong WW , 2001. Characteristics of patients with Burkholderia cepacia bacteremia. J Microbiol Immunol Infect 34: 215–219.
-
27.
Souza AV et al., 2004. Characterizing uncommon Burkholderia cepacia complex isolates from an outbreak in a haemodialysis unit. J Med Microbiol 53: 999–1005.
-
28.
Rastogi N et al., 2019. Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit. Int J Infect Dis 79: 4–11.
-
29.
Righi E et al., 2013. Characteristics and outcome predictors of patients involved in an outbreak of Burkholderia cepacia complex. J Hosp Infect 85: 73–75.
-
30.
El Chakhtoura NG , Saade E , Wilson BM , Perez F , Papp-Wallace KM , Bonomo RA , 2017. A 17-year nationwide study of Burkholderia cepacia complex bloodstream infections among patients in the United States Veterans Health Administration. Clin Infect Dis 65: 1327–1334.
-
31.
Chang TH , Chuang YC , Wang JT , Sheng WH , 2021. Clinical characteristics and outcomes of non-cystic fibrosis patients with Burkholderia cepacia complex bacteremia at a medical center in Taiwan. J Microbiol Immunol Infect 55: 1301–1309.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 849 | 849 | 180 |
| Full Text Views | 26 | 26 | 3 |
| PDF Downloads | 34 | 34 | 3 |