Article Category:
Review Article

The Impact of the Mycobacterium tuberculosis RDRio Subfamily on Multidrug-Resistant Tuberculosis in Latin America: A Comprehensive Review

Bernardo Castro-Rodríguez One Health Research Group, Universidad de Las Américas, Quito, Ecuador;

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Cristina Cazar-Ramos One Health Research Group, Universidad de Las Américas, Quito, Ecuador;

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Greta Franco-Sotomayor Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador;
Universidad Católica Santiago de Guayaquil, Guayaquil, Ecuador;

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Greta Ester Cardenas-Franco Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador;

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Solon Alberto Orlando Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador;
Universidad Espíritu Santo, Guayaquil, Ecuador

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Miguel Angel García-Bereguiain One Health Research Group, Universidad de Las Américas, Quito, Ecuador;

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DOI:
https://doi.org/10.4269/ajtmh.24-0073
Volume/Issue:
Volume 111: Issue 2
Page(s):
230–236
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ABSTRACT.

Latin American region is a high-burden setting for tuberculosis where multidrug-resistant tuberculosis (MDR-TB) is among the main challenge to move forward the End TB Strategy goals. It has been shown that MDR-TB is associated to certain Mycobacterium tuberculosis (MTB) lineages like L2-Beijing sublineage or L4-LAM. Although L2-Beijing is present in South America, the L4 lineage is the most prevalent with values ranging from 75% to 99% depending on the country. Within L4, Latin American–Mediterranean (LAM) family is the most prevalent. Moreover, within LAM, RDRio subfamily is present in high prevalence in several countries in South America like Venezuela or Brazil. RDRio has been associated to MDR-TB in several studies in Brazil but more epidemiological information is needed for South America. Here we discuss the problem of MDR-TB in Latin America and the potential threat that RDRio could represent. At this time, more molecular epidemiology studies are necessary to improve TB surveillance programs in Latin America by tracking MTB strains potentially responsible for MDR-TB spread.

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Author Notes

Financial support: This research was funded by Universidad de las Américas (MED.MGB.23.01).

Current contact information: Bernardo Castro-Rodríguez, Cristina Cazar-Ramos, and Miguel Angel García-Bereguiain, One Health Research Group, Universidad de las Américas, Quito, Ecuador, E-mails: bernardo.castro@udla.edu.ec, cristina.cazar@udla.edu.ec, and magbereguiain@gmail.com. Greta Franco-Sotomayor, Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador, and Universidad Católica Santiago de Guayaquil, Guayaquil, Ecuador, E-mail: gfranco@inspi.gob.ec. Greta Ester Cardenas-Franco, Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador, E-mail: greta_card2210@outlook.es. Solon Alberto Orlando, Instituto Nacional de Salud Pública e Investigación, Guayaquil, Ecuador, and Universidad Espíritu Santo, Guayaquil, Ecuador, E-mail: aorlando@inspi.gob.ec.

Address correspondence to Miguel Angel Garcia-Bereguiain, Redondel del Ciclista, Antigua Vía a Nayón, Campus UDLAPark, Quito, Ecuador. E-mail: magbereguiain@gmail.com
Copyright:
© American Society of Tropical Medicine and Hygiene 2024
Received:
30 Jan 2024
|
Accepted:
24 Apr 2024
|
Published Online:
02 Jul 2024
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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