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1.
Trabelsi H , Dendana F , Sallami A , Sellami H , Cheikhrouhou F , Neji S , Makni F , Ayadi A , 2012. Pathogenic free-living amoebae: Epidemiology and clinical review. Pathol Biol (Paris) 60: 399–405.
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2.
Haston JC , O’Laughlin K , Matteson K , Roy S , Qvarnstrom Y , Ali IKM , Cope JR , 2023. The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956–2020. Open Forum Infect Dis 10: ofac682.
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3.
Tami TA , Wawrose MMSF , 1992. Diseases of the nose and pnasal sinuses in the human immunodeficiency virus-infected population. Otolaryngol Clin North Am 25: 1199–1210.
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4.
Guirguis D , Kashat L , Moradi S , Bonaiuto GS , 2022. An unusual source of sinonasal disease in an immunocompromised patient: A case report of the clinical presentation, diagnosis, and treatment of Acanthamoeba rhinosinusitis. Ear Nose Throat J 101: NP316–NP310.
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5.
Rice CA , Colon BL , Chen E , Hull MV , Kyle DE , 2020. Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae. PLoS Negl Trop Dis 14: e0008353.
-
6.
McLean AC , Bishop JA , Guarner J , Montone KT , Morris CP , Sloan P , Rooper LM , 2023. Sinonasal amoebiasis: An unexpected cause of sinonasal necroinflammatory disease. Am J Surg Pathol 47: 102–110.
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7.
Teknos TN , Poulin MD , Laruentano AM , Li KK , 2000. Acanthamoeba rhinosinusitis: Characterization, diagnosis, and treatment. Am J Rhinol 21: 398–391.
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8.
Simner PJ , Miller S , Carroll KC , 2018. Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases. Clin Infect Dis 66: 778–788.
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9.
Taravaud A , Fechtali-Moute Z , Loiseau PM , Pomel S , 2021. Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae. Clin Transl Sci 14: 791–805.
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10.
CDC , 2017. Sinus Rinsing For Health or Religious Practice. Available at: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html. Accessed December 7, 2023.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1886 | 1886 | 61 |
| Full Text Views | 69 | 69 | 5 |
| PDF Downloads | 88 | 88 | 5 |
Case Report: Management of Acanthamoeba Rhinosinusitis in a Patient with Chronic Lymphocytic Leukemia
Elizabeth Di Valerio
Elizabeth Di Valerio
University of Florida College of Medicine, Gainesville, Florida;
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Jeb M. Justice
Jeb M. Justice
Division of Rhinology and Skull Base Surgery, Department of Otolaryngology, University of Florida College of Medicine, Gainesville, Florida;
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Alexis C. Gushiken
Alexis C. Gushiken
Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;
Section of Infectious Diseases, North Florida/South Georgia Veterans Health System, Gainesville, Florida
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Section of Infectious Diseases, North Florida/South Georgia Veterans Health System, Gainesville, Florida
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ABSTRACT.
Infections caused by free-living amoebae pose a significant public health threat owing to growing populations of immunocompromised hosts combined with diagnostic delays, treatment difficulties, and high case fatality rates. Nasopharyngeal infections caused by Acanthamoeba are rare and the optimal treatment is not well established. We report a case of Acanthamoeba rhinosinusitis in a patient with chronic lymphocytic leukemia who presented with headaches and chronic rhinosinusitis refractory to multiple courses of antibiotics. A diagnosis of Acanthamoeba rhinosinusitis was established through broad-range polymerase chain reaction testing on sinus tissue. The patient had a favorable response to treatment, which included surgical debridement, cessation of immunosuppressants, and a three-drug regimen consisting of miltefosine, fluconazole, and sulfadiazine.
Author Notes
Authors’ addresses: Elizabeth Di Valerio, Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, E-mail: divalerio@wustl.edu. Jeb M. Justice, Division of Rhinology and Skull Base Surgery, Department of Otolaryngology, University of Florida College of Medicine, Gainesville, FL, E-mail: jeb.justice@ent.ufl.edu. Alexis C. Gushiken, Section of Infectious Diseases, North Florida/South Georgia Veterans Affairs Health System, Gainesville, FL, E-mail: alexis.gushiken@medicine.ufl.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Trabelsi H , Dendana F , Sallami A , Sellami H , Cheikhrouhou F , Neji S , Makni F , Ayadi A , 2012. Pathogenic free-living amoebae: Epidemiology and clinical review. Pathol Biol (Paris) 60: 399–405.
-
2.
Haston JC , O’Laughlin K , Matteson K , Roy S , Qvarnstrom Y , Ali IKM , Cope JR , 2023. The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956–2020. Open Forum Infect Dis 10: ofac682.
-
3.
Tami TA , Wawrose MMSF , 1992. Diseases of the nose and pnasal sinuses in the human immunodeficiency virus-infected population. Otolaryngol Clin North Am 25: 1199–1210.
-
4.
Guirguis D , Kashat L , Moradi S , Bonaiuto GS , 2022. An unusual source of sinonasal disease in an immunocompromised patient: A case report of the clinical presentation, diagnosis, and treatment of Acanthamoeba rhinosinusitis. Ear Nose Throat J 101: NP316–NP310.
-
5.
Rice CA , Colon BL , Chen E , Hull MV , Kyle DE , 2020. Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae. PLoS Negl Trop Dis 14: e0008353.
-
6.
McLean AC , Bishop JA , Guarner J , Montone KT , Morris CP , Sloan P , Rooper LM , 2023. Sinonasal amoebiasis: An unexpected cause of sinonasal necroinflammatory disease. Am J Surg Pathol 47: 102–110.
-
7.
Teknos TN , Poulin MD , Laruentano AM , Li KK , 2000. Acanthamoeba rhinosinusitis: Characterization, diagnosis, and treatment. Am J Rhinol 21: 398–391.
-
8.
Simner PJ , Miller S , Carroll KC , 2018. Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases. Clin Infect Dis 66: 778–788.
-
9.
Taravaud A , Fechtali-Moute Z , Loiseau PM , Pomel S , 2021. Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae. Clin Transl Sci 14: 791–805.
-
10.
CDC , 2017. Sinus Rinsing For Health or Religious Practice. Available at: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html. Accessed December 7, 2023.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1886 | 1886 | 61 |
| Full Text Views | 69 | 69 | 5 |
| PDF Downloads | 88 | 88 | 5 |