Boer CG et al., 2021. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell 184: 4784–4818.e17.
Auffray C , Charron D , Hood L , 2010. Predictive, preventive, personalized and participatory medicine: Back to the future. Genome Med 2: 57.
McGuire AL et al., 2020. The road ahead in genetics and genomics. Nat Rev Genet 21: 581–596.
Ceballos FC et al., 2020. Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study. Nat Commun 11: 5754.
Lucas-Sánchez M , Serradell JM , Comas D , 2021. Population history of North Africa based on modern and ancient genomes. Hum Mol Genet 30: R17–R23.
Fatumo S , Chikowore T , Choudhury A , Ayub M , Martin AR , Kuchenbaecker K , 2022. A roadmap to increase diversity in genomic studies. Nat Med 28: 243–250.
McHenry ML , Wampande EM , Joloba ML , Malone LL , Mayanja-Kizza H , Bush WS , Boom WH , Williams SM , Stein CM , 2021. Interaction between M. tuberculosis lineage and human genetic variants reveals novel pathway associations with severity of TB. Pathogens 10: 1487.
Perroud N , Rutembesa E , Paoloni-Giacobino A , Mutabaruka J , Mutesa L , Stenz L , Malafosse A , Karege F , 2014. The Tutsi genocide and transgenerational transmission of maternal stress: Epigenetics and biology of the HPA axis. World J Biol Psychiatry 15: 334–345.
Abdrabou W et al., 2021. Metabolome modulation of the host adaptive immunity in human malaria. Nat Metab 3: 1001–1016.
Wardi M , Slimani N , Alla AA , Belmouden A , 2023. First study of the effect of wastewater treatment on microbial biodiversity at three wastewater treatment plants in Agadir, Morocco, using 16S rRNA sequencing. Environ Pollut 337: 122528.
El Ahanidi H et al., 2022. Immune checkpoint and telomerase crosstalk is mediated by miRNA-138 in bladder cancer. Front Oncol 11: 795242.
Pavlovic K , Tristán-Manzano M , Maldonado-Pérez N , Cortijo-Gutierrez M , Sánchez-Hernández S , Justicia-Lirio P , Carmona MD , Herrera C , Martin F , Benabdellah K , 2020. Using gene editing approaches to fine-tune the immune system. Front Immunol 11: 570672.
Quintana-Bustamante O , Fañanas-Baquero S , Dessy-Rodriguez M , Ojeda-Pérez I , Segovia JC , 2022. Gene editing for inherited red blood cell diseases. Front Physiol 13: 848261.
Murillo O et al., 2022. High value of 64Cu as a tool to evaluate the restoration of physiological copper excretion after gene therapy in Wilson’s disease. Mol Ther Methods Clin Dev 26: 98–106.
Zabaleta N et al., 2018. CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I. Nat Commun 9: 5454.
Li J , Li L , Sun X , Deng T , Huang G , Li X , Xie Z , Zhou Z , 2021. Role of Tet2 in regulating adaptive and innate immunity. Front Cell Dev Biol 9: 665897.
Atilla E , Benabdellah K , 2023. The black hole: CAR T cell therapy in AML. Cancers (Basel) 15: 2713.
Maldonado-Pérez N et al., 2022. Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma. Front Immunol 13: 1011858.
Past two years | Past Year | Past 30 Days | |
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Abstract Views | 3151 | 2515 | 137 |
Full Text Views | 100 | 84 | 5 |
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The 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference’s overarching theme was “Applications of Genomics Medicine in Africa,” covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders, cancer genetics, and translational genetics. The conference aimed to address the lag in the field of genetics in Africa and highlight the potential for genetic research and personalized medicine on the continent. The goal was to improve the health of African populations and global communities while nurturing the careers of young African scientists in the field. Distinguished scientists from around the world shared their recent findings in genetics, immunogenetics, genomics, genome editing, immunotherapy, and ethics genomics. Precongress activities included a 2-day bioinformatics workshop, “NGS Analysis for Monogenic Disease in African Populations,” and a Young Investigators Forum, providing opportunities for young African researchers to showcase their work. The vast genetic diversity of the African continent poses a significant challenge in investigating and characterizing public health issues at the genetic and functional levels. Training, research, and the development of expertise in genetics, immunology, genomics, and bioinformatics are vital for addressing these challenges and advancing genetics in Africa. The AfSHG is committed to leading efforts to enhance genetic research, coordinate training, and foster research collaborations on the continent.
Financial support: The meeting was sponsored by the
Disclosure: A. Matiba and K. Chappell are employed by the Wellcome Connecting Science, a funder based in the United Kingdom; however, no Wellcome funds have contributed to this publication. The authors declare no conflict of interest.
Authors’ addresses: Meryem Fakhkhari, Ikram Salih, Najwa Maazaz, and Khalid Sadki, Research Laboratory in Oral Biology and Biotechnology, Faculty of Dental Medicine, Mohammed V University in Rabat, Morocco, and Institut of Biological Sciences, Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben Guerir, Morocco, E-mails: Meryem_Fakhkhari@um5.ac.ma, Ikram.salih@um5r.ac.ma, Najwa.MAAZAZ@um6p.ma, and k.sadki@um5r.ac.ma. Victoria Nembaware and Nchangwi Syntia Munung, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, E-mails: victoria.nembaware@uct.ac.za and nchangwisyntia@yahoo.com. Alice Matimba and Karon Chappell, Advanced Courses and Scientific Conferences, Wellcome Genome Campus, Hinxston, United Kingdom, E-mails: alice.matimba@wellcomeconnectingscience.org and karon.chappell@wellcomeconnectingscience.org. Sanaa Chala, Mohamed V Hospital of Military Instruction, Mohamed V University, Faculty of Dental Medicine of Rabat, Morocco, E-mail: s.chala@um5r.ac.ma. Ahmed Belmouden, Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco, E-mail: a.belmouden@uiz.ac.ma. Leon Mutesa, Einstein-Rwanda Research and Capacity Building Program, Research for Development, Kigali, Rwanda, Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda, E-mail: lmutesa@gmail.com. Ghada El-Kamah, Department of Clinical Genetics, Human Genetics and Genome Research Division, National Research Center, Cairo, Egypt. E-mail: ghadaelkamah@hotmail.com. Hicham Oumzil, Medical Biotechnology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, E-mail: droumzil@gmail.com. Larbi Baassi, Office of the Laboratories of the National Institute of Hygiene, Ministry of Health, Rabat, Morocco, E-mail: larbi.baassi@gmail.com. Younes Abbas, Polyvalent Team in R&D, Polydisciplinary Faculty, Sultan Moulay Slimane University, Beni Mellal, Morocco, E-mail: abbayouns@gmail.com. Mohamed Zahir Alimohamed, Department of Biochemistry and Molecular Biology, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Tanzania Human Genetics Organisation, Dar-es-Salaam, Tanzania, E-mail: mzahir89@gmail.com. Michele Ramsay, Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, E-mail: Michele.Ramsay@wits.ac.za. Scott Williams, Department of Population and Quantitative Health Sciences, School of Medicine, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, E-mail: smw154@case.edu. Karim Benabdelah, Department of Genomic Medicine, Pfizer-University of Granada, Andalusian Regional Government Center for Genomics and Oncological Research, Granada, Spain, E-mail: karim.benabdel@genyo.es. Youssef Idaghdour, Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Saadiyat Island, Abu Dhabi, United Arab Emirates, E-mail: youssef.idaghdour@nyu.edu. Ambroise Wonkam, McKusick-Nathans Institute and Department of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, MD, E-mail: awonkam1@jhmi.edu.
Boer CG et al., 2021. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell 184: 4784–4818.e17.
Auffray C , Charron D , Hood L , 2010. Predictive, preventive, personalized and participatory medicine: Back to the future. Genome Med 2: 57.
McGuire AL et al., 2020. The road ahead in genetics and genomics. Nat Rev Genet 21: 581–596.
Ceballos FC et al., 2020. Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study. Nat Commun 11: 5754.
Lucas-Sánchez M , Serradell JM , Comas D , 2021. Population history of North Africa based on modern and ancient genomes. Hum Mol Genet 30: R17–R23.
Fatumo S , Chikowore T , Choudhury A , Ayub M , Martin AR , Kuchenbaecker K , 2022. A roadmap to increase diversity in genomic studies. Nat Med 28: 243–250.
McHenry ML , Wampande EM , Joloba ML , Malone LL , Mayanja-Kizza H , Bush WS , Boom WH , Williams SM , Stein CM , 2021. Interaction between M. tuberculosis lineage and human genetic variants reveals novel pathway associations with severity of TB. Pathogens 10: 1487.
Perroud N , Rutembesa E , Paoloni-Giacobino A , Mutabaruka J , Mutesa L , Stenz L , Malafosse A , Karege F , 2014. The Tutsi genocide and transgenerational transmission of maternal stress: Epigenetics and biology of the HPA axis. World J Biol Psychiatry 15: 334–345.
Abdrabou W et al., 2021. Metabolome modulation of the host adaptive immunity in human malaria. Nat Metab 3: 1001–1016.
Wardi M , Slimani N , Alla AA , Belmouden A , 2023. First study of the effect of wastewater treatment on microbial biodiversity at three wastewater treatment plants in Agadir, Morocco, using 16S rRNA sequencing. Environ Pollut 337: 122528.
El Ahanidi H et al., 2022. Immune checkpoint and telomerase crosstalk is mediated by miRNA-138 in bladder cancer. Front Oncol 11: 795242.
Pavlovic K , Tristán-Manzano M , Maldonado-Pérez N , Cortijo-Gutierrez M , Sánchez-Hernández S , Justicia-Lirio P , Carmona MD , Herrera C , Martin F , Benabdellah K , 2020. Using gene editing approaches to fine-tune the immune system. Front Immunol 11: 570672.
Quintana-Bustamante O , Fañanas-Baquero S , Dessy-Rodriguez M , Ojeda-Pérez I , Segovia JC , 2022. Gene editing for inherited red blood cell diseases. Front Physiol 13: 848261.
Murillo O et al., 2022. High value of 64Cu as a tool to evaluate the restoration of physiological copper excretion after gene therapy in Wilson’s disease. Mol Ther Methods Clin Dev 26: 98–106.
Zabaleta N et al., 2018. CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I. Nat Commun 9: 5454.
Li J , Li L , Sun X , Deng T , Huang G , Li X , Xie Z , Zhou Z , 2021. Role of Tet2 in regulating adaptive and innate immunity. Front Cell Dev Biol 9: 665897.
Atilla E , Benabdellah K , 2023. The black hole: CAR T cell therapy in AML. Cancers (Basel) 15: 2713.
Maldonado-Pérez N et al., 2022. Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma. Front Immunol 13: 1011858.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 3151 | 2515 | 137 |
Full Text Views | 100 | 84 | 5 |
PDF Downloads | 96 | 79 | 5 |