Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Wiersinga WJ , Virk HS , Torres AG , Currie BJ , Peacock SJ , Dance DAB , Limmathurotsakul D , 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
-
2.
Teparrakkul P , Tsai JJ , Chierakul W , Gerstenmaier JF , Wacharaprechasgu T , Piyaphanee W , Limmathurotsakul D , Chaowagul W , Day NP , Peacock SJ , 2008. Rheumatological manifestations in patients with melioidosis. Southeast Asian J Trop Med Public Health 39: 649–655.
-
3.
Morse LP , Smith J , Mehta J , Ward L , Cheng AC , Currie BJ , 2013. Osteomyelitis and septic arthritis from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study from northern Australia. J Orthop 10: 86–91.
-
4.
Wu H , Wang X , Zhou X , Chen S , Mai W , Huang H , You Z , Zhang S , Zhang X , Lu B , 2021. Osteomyelitis and septic arthritis due to Burkholderia pseudomallei: A 10-year retrospective melioidosis study from south China. Front Cell Infect Microbiol 11: 654745.
-
5.
Chetchotisakd P , Porramatikul S , Mootsikapun P , Anunnatsiri S , Thinkhamrop B , 2001. Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. Clin Infect Dis 33: 29–34.
-
6.
Teparrukkul P , Nilsakul J , Dunachie S , Limmathurotsakul D , 2017. Clinical epidemiology of septic arthritis caused by Burkholderia pseudomallei and other bacterial pathogens in northeast Thailand. Am J Trop Med Hyg 97: 1695–1701.
-
7.
Shetty RP , Mathew M , Smith J , Morse LP , Mehta JA , Currie BJ , 2015. Management of melioidosis osteomyelitis and septic arthritis. Bone Joint J 97-B: 277–282.
-
8.
Gassiep I , Armstrong M , Norton R , 2020. Human melioidosis. Clin Microbiol Rev 33: e00006–e00019.
-
9.
Dance D , 2014. Treatment and prophylaxis of melioidosis. Int J Antimicrob Agents 43: 310–318.
-
10.
Churuangsuk C , Chusri S , Hortiwakul T , Charernmak B , Silpapojakul K , 2016. Characteristics, clinical outcomes and factors influencing mortality of patients with melioidosis in southern Thailand: A 10-year retrospective study. Asian Pac J Trop Med 9: 256–260.
-
11.
Currie BJ , Ward L , Cheng AC , 2010. The epidemiology and clinical spectrum of melioidosis: 540 Cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
12.
Chantratita N et al., 2023. Characteristics and one year outcomes of melioidosis patients in northeastern Thailand: A prospective, multicenter cohort study. Lancet Reg Health Southeast Asia 9: 100118.
-
13.
Dubey DK , Bano N , Dubey M , Sangwan P , Mitra SK , Kulshrestha V , Jain B , Mehdi I , 2023. A case series of melioidosis: An underdiagnosed infection. IDCases 31: e01685.
-
14.
Chowdhury S et al., 2022. The epidemiology of melioidosis and its association with diabetes mellitus: A systematic review and meta-analysis. Pathogens 11: 149.
-
15.
Kaewrakmuk J et al., 2023. Under-reporting cases and deaths from melioidosis: A retrospective finding in Songkhla and Phatthalung Province of southern Thailand, 2014–2020. Trop Med Infect Dis 8: 286.
-
16.
Kosuwon W , Taimglang T , Sirichativapee W , Jeeravipoolvarn P , 2003. Melioidotic septic arthritis and its risk factors. J Bone Joint Surg Am 85: 1058–1061.
-
17.
Suputtamongkol Y et al., 1999. Risk factors for melioidosis and bacteremic melioidosis. Clin Infect Dis 29: 408–413.
-
18.
Zueter A , Yean CY , Abumarzouq M , Rahman ZA , Deris ZZ , Harun A , 2016. The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a north-eastern state of Malaysia: A fifteen-year review. BMC Infect Dis 16: 333.
-
19.
Hinjoy S et al., 2018. Melioidosis in Thailand: Present and future. Trop Med Infect Dis 3: 38.
-
20.
Limmathurotsakul D , Wongratanacheewin S , Teerawattanasook N , Wongsuvan G , Chaisuksant S , Chetchotisakd P , Chaowagul W , Day NP , Peacock SJ , 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
21.
Thabit AK , Fatani DF , Bamakhrama MS , Barnawi OA , Basudan LO , Alhejaili SF , 2019. Antibiotic penetration into bone and joints: An updated review. Int J Infect Dis 81: 128–136.
-
22.
Landersdorfer CB , Bulitta JB , Kinzig M , Holzgrabe U , Sörgel F , 2009. Penetration of antibacterials into bone: Pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 48: 89–124.
-
23.
Mabille C , El Samad Y , Joseph C , Brunschweiler B , Goeb V , Grados F , Lanoix JP , 2021. Medical versus surgical treatment in native hip and knee septic arthritis. Infect Dis Now 51: 164–169.
-
24.
Coakley G et al., 2006. BSR & BHPR, BOA, RCGP and BSAC guidelines for management of the hot swollen joint in adults. Rheumatology (Oxford) 45: 1039–1041.
-
25.
Goldenberg DL , Brandt KD , Cohen AS , Cathcart ES , 1975. Treatment of septic arthritis: Comparison of needle aspiration and surgery as initial modes of joint drainage. Arthritis Rheum 18: 83–90.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1026 | 1022 | 156 |
| Full Text Views | 75 | 75 | 13 |
| PDF Downloads | 121 | 121 | 13 |
Outcomes of Adjunctive Therapy with Open Arthrotomy for Patients with Septic Arthritis Due to Melioidosis: A Retrospective Study
Sorawit Chittrakarn
Sorawit Chittrakarn
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Pisud Siripaitoon
Pisud Siripaitoon
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Narongdet Kositpantawong
Narongdet Kositpantawong
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Siripen Kanchanasuwan
Siripen Kanchanasuwan
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Duangkamol Aiewruengsurat
Duangkamol Aiewruengsurat
Allergy and Rheumatology Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Piyawat Bintachitt
Piyawat Bintachitt
Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
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Boonsri Charoenmak
Boonsri Charoenmak
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Monchana Jullangkoon
Monchana Jullangkoon
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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Sarunyou Chusri
Sarunyou Chusri
Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand;
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ABSTRACT.
Melioidosis is a potentially fatal infection caused by the bacterium Burkholderia pseudomallei. Septic arthritis caused by this infection is uncommon and difficult to treat. The role of adjunctive open arthrotomy in this type of infection has not yet been elucidated. We conducted a retrospective study of patients with microbiologically confirmed melioidosis between January 2002 and December 2022. Patients with a clinical condition of septic arthritis and positive cultures for B. pseudomallei were included. Comparisons were made between patients who received adjunctive therapy with open arthrotomy with conventional standard treatment and those who did not in terms of clinical outcomes and hospital expenditures. Of the 478 patients diagnosed with melioidosis microbiological confirmation, 81 patients had septic arthritis, accounting for 17% of cases. Among these patients, only 36 (44%) underwent adjunctive therapy with open arthrotomy. The 14-day and 30-day in-hospital mortality and length of hospital stays of patients who underwent adjunctive therapy with open arthrotomy were more favorable than those of patients who did not receive adjunctive therapy with open arthrotomy; however, the difference was not statistically significant. Patients who underwent adjunctive therapy with open arthrotomy had lower hospital expenditures (antimicrobial and non-antimicrobial costs) than those who did not undergo open arthrotomy. Adjunctive therapy with open arthrotomy for patients with septic arthritis due to melioidosis was associated with favorable clinical outcomes and significantly lower hospital expenditures.
Author Notes
Disclosures: This study was approved by the Ethics Committee of the Faculty of Medicine, Prince of Songkla University (certification number: REC.66-349-14-1). The requirement for informed consent from participants or representatives was waived owing to the retrospective nature of the study, and the data were fully anonymized before analysis and presentation.
Authors’ addresses: Sorawit Chittrakarn, Pisud Siripaitoon, Narongdet Kositpantawong, Siripen Kanchanasuwan, Boonsri Charoenmak, Monchana Jullangkoon, and Sarunyou Chusri, Infectious Disease Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand, E-mails: sorawit.c@psu.ac.th, grippen45@gmail.com, poom_032@yahoo.com, kaymed29@yahoo.com, cboonsrii@medicine.psu.ac.th, nana_jittung@hotmail.com, and sarunyouchusri@hotmail.com. Duangkamol Aiewruengsurat, Allergy and Rheumatology Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand, E-mail: dklangkamol@yahoo.com. Piyawat Bintachitt, Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand, E-mail: piyabintap@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Wiersinga WJ , Virk HS , Torres AG , Currie BJ , Peacock SJ , Dance DAB , Limmathurotsakul D , 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
-
2.
Teparrakkul P , Tsai JJ , Chierakul W , Gerstenmaier JF , Wacharaprechasgu T , Piyaphanee W , Limmathurotsakul D , Chaowagul W , Day NP , Peacock SJ , 2008. Rheumatological manifestations in patients with melioidosis. Southeast Asian J Trop Med Public Health 39: 649–655.
-
3.
Morse LP , Smith J , Mehta J , Ward L , Cheng AC , Currie BJ , 2013. Osteomyelitis and septic arthritis from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study from northern Australia. J Orthop 10: 86–91.
-
4.
Wu H , Wang X , Zhou X , Chen S , Mai W , Huang H , You Z , Zhang S , Zhang X , Lu B , 2021. Osteomyelitis and septic arthritis due to Burkholderia pseudomallei: A 10-year retrospective melioidosis study from south China. Front Cell Infect Microbiol 11: 654745.
-
5.
Chetchotisakd P , Porramatikul S , Mootsikapun P , Anunnatsiri S , Thinkhamrop B , 2001. Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. Clin Infect Dis 33: 29–34.
-
6.
Teparrukkul P , Nilsakul J , Dunachie S , Limmathurotsakul D , 2017. Clinical epidemiology of septic arthritis caused by Burkholderia pseudomallei and other bacterial pathogens in northeast Thailand. Am J Trop Med Hyg 97: 1695–1701.
-
7.
Shetty RP , Mathew M , Smith J , Morse LP , Mehta JA , Currie BJ , 2015. Management of melioidosis osteomyelitis and septic arthritis. Bone Joint J 97-B: 277–282.
-
8.
Gassiep I , Armstrong M , Norton R , 2020. Human melioidosis. Clin Microbiol Rev 33: e00006–e00019.
-
9.
Dance D , 2014. Treatment and prophylaxis of melioidosis. Int J Antimicrob Agents 43: 310–318.
-
10.
Churuangsuk C , Chusri S , Hortiwakul T , Charernmak B , Silpapojakul K , 2016. Characteristics, clinical outcomes and factors influencing mortality of patients with melioidosis in southern Thailand: A 10-year retrospective study. Asian Pac J Trop Med 9: 256–260.
-
11.
Currie BJ , Ward L , Cheng AC , 2010. The epidemiology and clinical spectrum of melioidosis: 540 Cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
12.
Chantratita N et al., 2023. Characteristics and one year outcomes of melioidosis patients in northeastern Thailand: A prospective, multicenter cohort study. Lancet Reg Health Southeast Asia 9: 100118.
-
13.
Dubey DK , Bano N , Dubey M , Sangwan P , Mitra SK , Kulshrestha V , Jain B , Mehdi I , 2023. A case series of melioidosis: An underdiagnosed infection. IDCases 31: e01685.
-
14.
Chowdhury S et al., 2022. The epidemiology of melioidosis and its association with diabetes mellitus: A systematic review and meta-analysis. Pathogens 11: 149.
-
15.
Kaewrakmuk J et al., 2023. Under-reporting cases and deaths from melioidosis: A retrospective finding in Songkhla and Phatthalung Province of southern Thailand, 2014–2020. Trop Med Infect Dis 8: 286.
-
16.
Kosuwon W , Taimglang T , Sirichativapee W , Jeeravipoolvarn P , 2003. Melioidotic septic arthritis and its risk factors. J Bone Joint Surg Am 85: 1058–1061.
-
17.
Suputtamongkol Y et al., 1999. Risk factors for melioidosis and bacteremic melioidosis. Clin Infect Dis 29: 408–413.
-
18.
Zueter A , Yean CY , Abumarzouq M , Rahman ZA , Deris ZZ , Harun A , 2016. The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a north-eastern state of Malaysia: A fifteen-year review. BMC Infect Dis 16: 333.
-
19.
Hinjoy S et al., 2018. Melioidosis in Thailand: Present and future. Trop Med Infect Dis 3: 38.
-
20.
Limmathurotsakul D , Wongratanacheewin S , Teerawattanasook N , Wongsuvan G , Chaisuksant S , Chetchotisakd P , Chaowagul W , Day NP , Peacock SJ , 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
21.
Thabit AK , Fatani DF , Bamakhrama MS , Barnawi OA , Basudan LO , Alhejaili SF , 2019. Antibiotic penetration into bone and joints: An updated review. Int J Infect Dis 81: 128–136.
-
22.
Landersdorfer CB , Bulitta JB , Kinzig M , Holzgrabe U , Sörgel F , 2009. Penetration of antibacterials into bone: Pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 48: 89–124.
-
23.
Mabille C , El Samad Y , Joseph C , Brunschweiler B , Goeb V , Grados F , Lanoix JP , 2021. Medical versus surgical treatment in native hip and knee septic arthritis. Infect Dis Now 51: 164–169.
-
24.
Coakley G et al., 2006. BSR & BHPR, BOA, RCGP and BSAC guidelines for management of the hot swollen joint in adults. Rheumatology (Oxford) 45: 1039–1041.
-
25.
Goldenberg DL , Brandt KD , Cohen AS , Cathcart ES , 1975. Treatment of septic arthritis: Comparison of needle aspiration and surgery as initial modes of joint drainage. Arthritis Rheum 18: 83–90.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1026 | 1022 | 156 |
| Full Text Views | 75 | 75 | 13 |
| PDF Downloads | 121 | 121 | 13 |