Increased Prevalence of Antibodies to Hepatitis E Virus in Patients with Neurocysticercosis

Jesus Abanto Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Neurology, University of Cincinnati, Cincinnati, Ohio;

Search for other papers by Jesus Abanto in
Current site
Google Scholar
PubMed
Close
,
Arantxa N. Sanchez Boluarte Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Global Health, University of Washington, Seattle, Washington;

Search for other papers by Arantxa N. Sanchez Boluarte in
Current site
Google Scholar
PubMed
Close
,
Yesenia Castillo Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;

Search for other papers by Yesenia Castillo in
Current site
Google Scholar
PubMed
Close
,
Erika Perez Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

Search for other papers by Erika Perez in
Current site
Google Scholar
PubMed
Close
,
Herbert Saavedra Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

Search for other papers by Herbert Saavedra in
Current site
Google Scholar
PubMed
Close
,
Isidro Gonzales Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

Search for other papers by Isidro Gonzales in
Current site
Google Scholar
PubMed
Close
,
Javier A. Bustos Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

Search for other papers by Javier A. Bustos in
Current site
Google Scholar
PubMed
Close
,
Florence Abravanel Laboratoire de Virologie, CHU Purpan, Toulouse, France;

Search for other papers by Florence Abravanel in
Current site
Google Scholar
PubMed
Close
,
Jacques Izopet Laboratoire de Virologie, CHU Purpan, Toulouse, France;

Search for other papers by Jacques Izopet in
Current site
Google Scholar
PubMed
Close
,
Richie G. Madden Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)

Search for other papers by Richie G. Madden in
Current site
Google Scholar
PubMed
Close
,
Hector H. Garcia Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;

Search for other papers by Hector H. Garcia in
Current site
Google Scholar
PubMed
Close
, and
Harry R. Dalton Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)

Search for other papers by Harry R. Dalton in
Current site
Google Scholar
PubMed
Close
for the Cysticercosis Working Group in Peru
Restricted access

ABSTRACT.

We explored the association between serological status for hepatitis E and neurocysticercosis (NCC) in neurologic patients attending a national neurological referral center in Lima, Perú, between the years 2008 and 2012. Anti-hepatitis E antibodies were evaluated in patients with and without NCC, and a control group of rural general population. Anti-hepatitis E IgG was found in 23.8% of patients with NCC, compared with 14.3% in subjects without NCC from a general rural population (P = 0.023) and 14.4% in subjects with neurological complaints without NCC (P = 0.027). Seropositive patients had a median age of 44 years compared with 30 years in seronegative patients (P <0.001). No significant differences in sex, region of residence, or liver enzyme values were found. Seropositivity to hepatitis E was frequent in this Peruvian population and higher in patients with NCC, suggesting shared common routes of infection.

    • Supplemental Materials (PDF 14.080 KB)

Author Notes

Financial support: Beijing Wantai Biological donated the ELISA kits for detection of IgG and IgM antibodies against HEV used in this study. J. Abanto is partially supported by FIC NIH training grant TW001140.

Disclosure: The authors certify that they have no affiliations with or involvement in any entity with any financial interest.

Authors’ addresses: Jesus Abanto, Department of Neurology, University of Cincinnati, Cincinnati, OH, and Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: abantojs@ucmail.uc.edu. Arantxa N. Sanchez Boluarte, Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru, and Department of Global Health, University of Washington, Seattle, WA, E-mail: aransb21@uw.edu. Yesenia Castillo, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: yesenia.castillo.b@upch.pe. Erika Perez, Isidro Gonzales, and Herbert Saavedra, Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: erika.perez.p@upch.pe, isidrogonzalesq@hotmail.com, and hsaavedrapastor@hotmail.com. Javier A. Bustos and Hector H. Garcia, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, and Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: jbustos@jhsph.edu and hgarcia@jhsph.edu. Florence Abravanel and Jacques Izopet, Laboratoire de Virologie, CHU Purpan, Toulouse, France, E-mails: abravanel.f@chu-toulouse.fr and izopet.j@chu-toulouse.fr. Richie G. Madden and Harry R. Dalton, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, Australia, and HEV International Direct Action Group, E-mails: richie@forfey.com and hardalton@gmail.com.

Address correspondence to Arantxa N. Sanchez Boluarte, School of Medicine, Universidad Peruana Cayetano Heredia, Ave. Honorio Delgado 430, Lima 31, Peru. E-mail: aransb21@uw.edu
  • 1.

    Guerra JAAA , Kampa KC , Morsoletto DGB , Junior AP , Ivantes CAP , 2017. Hepatitis E: A literature review. J Clin Transl Hepatol 5: 376383.

  • 2.

    Kamar N , Izopet J , Pavio N , Aggarwal R , Labrique A , Wedemeyer H , Dalton HR , 2017. Hepatitis E virus infection. Nat Rev Dis Primers 3: 17086.

  • 3.

    Izopet J , Tremeaux P , Marion O , Migueres M , Capelli N , Chapuy-Regaud S , Mansuy J-M , Abravanel F , Kamar N , Lhomme S , 2019. Hepatitis E virus infections in Europe. J Clin Virol Off Publ Pan Am Soc Clin Virol 120: 2026.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    World Health Organization , 2023. Hepatitis E. Available at: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e. Accessed October 2, 2023.

    • PubMed
    • Export Citation
  • 5.

    Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention , 2021. Hepatitis E—FAQs, Resources, and Testing Requests. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/hepatitis/hev/index.htm. Accessed March 30, 2021.

    • PubMed
    • Export Citation
  • 6.

    Thom K et al., 2018. Hepatitis E virus (HEV) in Scotland: Evidence of recent increase in viral circulation in humans. Euro Surveill 23: 17-00174.

  • 7.

    Van der Poel WHM , Dalton HR , Johne R , Pavio N , Bouwknegt M , Wu T , Cook N , Meng XJ , 2018. Knowledge gaps and research priorities in the prevention and control of hepatitis E virus infection. Transbound Emerg Dis 65 (Suppl 1 ):2229.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Pischke S et al., 2019. Chronic Hepatitis E in rheumatology and internal medicine patients: A retrospective multicenter European cohort study. Viruses 11: 186.

  • 9.

    Rivero-Juarez A , Lopez-Lopez P , Frias M , Rivero A , 2019. Hepatitis E infection in HIV-infected patients. Front Microbiol 10: 1425.

  • 10.

    Mclean BN , Gulliver J , Dalton HR , 2017. Hepatitis E virus and neurological disorders. Pract Neurol 17: 282288.

  • 11.

    Garcia HH , Nash TE , Del Brutto OH , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 12021215.

  • 12.

    Fierro NA , Realpe M , Meraz-Medina T , Roman S , Panduro A , 2016. Hepatitis E virus: An ancient hidden enemy in Latin America. World J Gastroenterol 22: 22712283.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Garcia HH , Lescano AG , Gonzales I , Bustos JA , Pretell EJ , Horton J , Saavedra H , Gonzalez AE , Gilman RH , Cysticercosis Working Group in Peru , 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clin Infect Dis Off Publ Infect Dis Soc Am 62: 13751379.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Garcia HH , Gonzales I , Lescano AG , Bustos JA , Pretell EJ , Saavedra H , Nash TE , Cysticercosis Working Group in Peru , 2014. Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after. Epilepsia 55: 14521459.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Garcia HH et al., Cysticercosis Working Group in Peru , 2014. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: A double-blind, randomised controlled trial. Lancet Infect Dis 14: 687695.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Garcia HH et al., 2016. Elimination of Taenia solium transmission in northern Peru. N Engl J Med 374: 23352344.

  • 17.

    Vildosola H , Colichón A , Barreda M , Piscoya J , Palacios O , 2000. Hepatitis E IgG antibodies seroprevalence in a Peruvian risk group [in Spanish]. Rev Gastroenterol Peru Organo Soc Gastroenterol Peru 20: 111116.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Passos-Castilho AM , Reinaldo MR , de Sena A , Granato CFH , 2017. High prevalence of hepatitis E virus antibodies in Sao Paulo, southeastern Brazil: Analysis of a group of blood donors representative of the general population. Braz J Infect Dis Off Publ Braz Soc Infect Dis 21: 535539.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Campolmi I et al., 2018. Seroprevalence of hepatitis A virus, hepatitis E virus, and Helicobacter pylori in rural communities of the Bolivian Chaco, 2013. Am J Trop Med Hyg 98: 12751280.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Wallace SJ et al., 2017. Investigation of liver dysfunction: Who should we test for hepatitis E? Eur J Gastroenterol Hepatol 29: 215220.

  • 21.

    Chandnani M , Kaur M , Ramadhas A , Tumarinson T , 2016. A case report about the most common yet most forgotten hepatitis E. Am J Case Rep 17: 584586.

  • 22.

    Sarda P , Sharma SK , Mohan A , Makharia G , Jayaswal A , Pandey RM , Singh S , 2009. Role of acute viral hepatitis as a confounding factor in antituberculosis treatment induced hepatotoxicity. Indian J Med Res 129: 6467.

    • PubMed
    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 358 358 70
Full Text Views 25 25 4
PDF Downloads 38 38 5
 
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save