Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Guerra JAAA , Kampa KC , Morsoletto DGB , Junior AP , Ivantes CAP , 2017. Hepatitis E: A literature review. J Clin Transl Hepatol 5: 376–383.
-
2.
Kamar N , Izopet J , Pavio N , Aggarwal R , Labrique A , Wedemeyer H , Dalton HR , 2017. Hepatitis E virus infection. Nat Rev Dis Primers 3: 17086.
-
3.
Izopet J , Tremeaux P , Marion O , Migueres M , Capelli N , Chapuy-Regaud S , Mansuy J-M , Abravanel F , Kamar N , Lhomme S , 2019. Hepatitis E virus infections in Europe. J Clin Virol Off Publ Pan Am Soc Clin Virol 120: 20–26.
-
4.
World Health Organization , 2023. Hepatitis E. Available at: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e. Accessed October 2, 2023.
-
5.
Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention , 2021. Hepatitis E—FAQs, Resources, and Testing Requests. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/hepatitis/hev/index.htm. Accessed March 30, 2021.
-
6.
Thom K et al., 2018. Hepatitis E virus (HEV) in Scotland: Evidence of recent increase in viral circulation in humans. Euro Surveill 23: 17-00174.
-
7.
Van der Poel WHM , Dalton HR , Johne R , Pavio N , Bouwknegt M , Wu T , Cook N , Meng XJ , 2018. Knowledge gaps and research priorities in the prevention and control of hepatitis E virus infection. Transbound Emerg Dis 65 (Suppl 1 ):22–29.
-
8.
Pischke S et al., 2019. Chronic Hepatitis E in rheumatology and internal medicine patients: A retrospective multicenter European cohort study. Viruses 11: 186.
-
9.
Rivero-Juarez A , Lopez-Lopez P , Frias M , Rivero A , 2019. Hepatitis E infection in HIV-infected patients. Front Microbiol 10: 1425.
-
10.
Mclean BN , Gulliver J , Dalton HR , 2017. Hepatitis E virus and neurological disorders. Pract Neurol 17: 282–288.
-
11.
Garcia HH , Nash TE , Del Brutto OH , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
12.
Fierro NA , Realpe M , Meraz-Medina T , Roman S , Panduro A , 2016. Hepatitis E virus: An ancient hidden enemy in Latin America. World J Gastroenterol 22: 2271–2283.
-
13.
Garcia HH , Lescano AG , Gonzales I , Bustos JA , Pretell EJ , Horton J , Saavedra H , Gonzalez AE , Gilman RH , Cysticercosis Working Group in Peru , 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clin Infect Dis Off Publ Infect Dis Soc Am 62: 1375–1379.
-
14.
Garcia HH , Gonzales I , Lescano AG , Bustos JA , Pretell EJ , Saavedra H , Nash TE , Cysticercosis Working Group in Peru , 2014. Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after. Epilepsia 55: 1452–1459.
-
15.
Garcia HH et al., Cysticercosis Working Group in Peru , 2014. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: A double-blind, randomised controlled trial. Lancet Infect Dis 14: 687–695.
-
16.
Garcia HH et al., 2016. Elimination of Taenia solium transmission in northern Peru. N Engl J Med 374: 2335–2344.
-
17.
Vildosola H , Colichón A , Barreda M , Piscoya J , Palacios O , 2000. Hepatitis E IgG antibodies seroprevalence in a Peruvian risk group [in Spanish]. Rev Gastroenterol Peru Organo Soc Gastroenterol Peru 20: 111–116.
-
18.
Passos-Castilho AM , Reinaldo MR , de Sena A , Granato CFH , 2017. High prevalence of hepatitis E virus antibodies in Sao Paulo, southeastern Brazil: Analysis of a group of blood donors representative of the general population. Braz J Infect Dis Off Publ Braz Soc Infect Dis 21: 535–539.
-
19.
Campolmi I et al., 2018. Seroprevalence of hepatitis A virus, hepatitis E virus, and Helicobacter pylori in rural communities of the Bolivian Chaco, 2013. Am J Trop Med Hyg 98: 1275–1280.
-
20.
Wallace SJ et al., 2017. Investigation of liver dysfunction: Who should we test for hepatitis E? Eur J Gastroenterol Hepatol 29: 215–220.
-
21.
Chandnani M , Kaur M , Ramadhas A , Tumarinson T , 2016. A case report about the most common yet most forgotten hepatitis E. Am J Case Rep 17: 584–586.
-
22.
Sarda P , Sharma SK , Mohan A , Makharia G , Jayaswal A , Pandey RM , Singh S , 2009. Role of acute viral hepatitis as a confounding factor in antituberculosis treatment induced hepatotoxicity. Indian J Med Res 129: 64–67.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1647 | 1515 | 548 |
| Full Text Views | 67 | 58 | 21 |
| PDF Downloads | 65 | 53 | 10 |
Increased Prevalence of Antibodies to Hepatitis E Virus in Patients with Neurocysticercosis
Jesus Abanto
Jesus Abanto
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Neurology, University of Cincinnati, Cincinnati, Ohio;
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Department of Neurology, University of Cincinnati, Cincinnati, Ohio;
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Arantxa N. Sanchez Boluarte
Arantxa N. Sanchez Boluarte
Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú;
Department of Global Health, University of Washington, Seattle, Washington;
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Department of Global Health, University of Washington, Seattle, Washington;
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Yesenia Castillo
Yesenia Castillo
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
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Erika Perez
Erika Perez
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Herbert Saavedra
Herbert Saavedra
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Isidro Gonzales
Isidro Gonzales
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Javier A. Bustos
Javier A. Bustos
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Florence Abravanel
Florence Abravanel
Laboratoire de Virologie, CHU Purpan, Toulouse, France;
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Jacques Izopet
Jacques Izopet
Laboratoire de Virologie, CHU Purpan, Toulouse, France;
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Richie G. Madden
Richie G. Madden
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)
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HEV International Direct Action Group (HEViDrAG)
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Hector H. Garcia
Hector H. Garcia
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Perú;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Perú;
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Harry R. Dalton
for the Cysticercosis Working Group in Peru
Harry R. Dalton
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, South Australia;
HEV International Direct Action Group (HEViDrAG)
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HEV International Direct Action Group (HEViDrAG)
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ABSTRACT.
We explored the association between serological status for hepatitis E and neurocysticercosis (NCC) in neurologic patients attending a national neurological referral center in Lima, Perú, between the years 2008 and 2012. Anti-hepatitis E antibodies were evaluated in patients with and without NCC, and a control group of rural general population. Anti-hepatitis E IgG was found in 23.8% of patients with NCC, compared with 14.3% in subjects without NCC from a general rural population (P = 0.023) and 14.4% in subjects with neurological complaints without NCC (P = 0.027). Seropositive patients had a median age of 44 years compared with 30 years in seronegative patients (P <0.001). No significant differences in sex, region of residence, or liver enzyme values were found. Seropositivity to hepatitis E was frequent in this Peruvian population and higher in patients with NCC, suggesting shared common routes of infection.
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Author Notes
Financial support: Beijing Wantai Biological donated the ELISA kits for detection of IgG and IgM antibodies against HEV used in this study. J. Abanto is partially supported by
Disclosure: The authors certify that they have no affiliations with or involvement in any entity with any financial interest.
Authors’ addresses: Jesus Abanto, Department of Neurology, University of Cincinnati, Cincinnati, OH, and Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: abantojs@ucmail.uc.edu. Arantxa N. Sanchez Boluarte, Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru, and Department of Global Health, University of Washington, Seattle, WA, E-mail: aransb21@uw.edu. Yesenia Castillo, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: yesenia.castillo.b@upch.pe. Erika Perez, Isidro Gonzales, and Herbert Saavedra, Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: erika.perez.p@upch.pe, isidrogonzalesq@hotmail.com, and hsaavedrapastor@hotmail.com. Javier A. Bustos and Hector H. Garcia, Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru, and Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru, E-mails: jbustos@jhsph.edu and hgarcia@jhsph.edu. Florence Abravanel and Jacques Izopet, Laboratoire de Virologie, CHU Purpan, Toulouse, France, E-mails: abravanel.f@chu-toulouse.fr and izopet.j@chu-toulouse.fr. Richie G. Madden and Harry R. Dalton, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, Australia, and HEV International Direct Action Group, E-mails: richie@forfey.com and hardalton@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Guerra JAAA , Kampa KC , Morsoletto DGB , Junior AP , Ivantes CAP , 2017. Hepatitis E: A literature review. J Clin Transl Hepatol 5: 376–383.
-
2.
Kamar N , Izopet J , Pavio N , Aggarwal R , Labrique A , Wedemeyer H , Dalton HR , 2017. Hepatitis E virus infection. Nat Rev Dis Primers 3: 17086.
-
3.
Izopet J , Tremeaux P , Marion O , Migueres M , Capelli N , Chapuy-Regaud S , Mansuy J-M , Abravanel F , Kamar N , Lhomme S , 2019. Hepatitis E virus infections in Europe. J Clin Virol Off Publ Pan Am Soc Clin Virol 120: 20–26.
-
4.
World Health Organization , 2023. Hepatitis E. Available at: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e. Accessed October 2, 2023.
-
5.
Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention , 2021. Hepatitis E—FAQs, Resources, and Testing Requests. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/hepatitis/hev/index.htm. Accessed March 30, 2021.
-
6.
Thom K et al., 2018. Hepatitis E virus (HEV) in Scotland: Evidence of recent increase in viral circulation in humans. Euro Surveill 23: 17-00174.
-
7.
Van der Poel WHM , Dalton HR , Johne R , Pavio N , Bouwknegt M , Wu T , Cook N , Meng XJ , 2018. Knowledge gaps and research priorities in the prevention and control of hepatitis E virus infection. Transbound Emerg Dis 65 (Suppl 1 ):22–29.
-
8.
Pischke S et al., 2019. Chronic Hepatitis E in rheumatology and internal medicine patients: A retrospective multicenter European cohort study. Viruses 11: 186.
-
9.
Rivero-Juarez A , Lopez-Lopez P , Frias M , Rivero A , 2019. Hepatitis E infection in HIV-infected patients. Front Microbiol 10: 1425.
-
10.
Mclean BN , Gulliver J , Dalton HR , 2017. Hepatitis E virus and neurological disorders. Pract Neurol 17: 282–288.
-
11.
Garcia HH , Nash TE , Del Brutto OH , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
12.
Fierro NA , Realpe M , Meraz-Medina T , Roman S , Panduro A , 2016. Hepatitis E virus: An ancient hidden enemy in Latin America. World J Gastroenterol 22: 2271–2283.
-
13.
Garcia HH , Lescano AG , Gonzales I , Bustos JA , Pretell EJ , Horton J , Saavedra H , Gonzalez AE , Gilman RH , Cysticercosis Working Group in Peru , 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clin Infect Dis Off Publ Infect Dis Soc Am 62: 1375–1379.
-
14.
Garcia HH , Gonzales I , Lescano AG , Bustos JA , Pretell EJ , Saavedra H , Nash TE , Cysticercosis Working Group in Peru , 2014. Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after. Epilepsia 55: 1452–1459.
-
15.
Garcia HH et al., Cysticercosis Working Group in Peru , 2014. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: A double-blind, randomised controlled trial. Lancet Infect Dis 14: 687–695.
-
16.
Garcia HH et al., 2016. Elimination of Taenia solium transmission in northern Peru. N Engl J Med 374: 2335–2344.
-
17.
Vildosola H , Colichón A , Barreda M , Piscoya J , Palacios O , 2000. Hepatitis E IgG antibodies seroprevalence in a Peruvian risk group [in Spanish]. Rev Gastroenterol Peru Organo Soc Gastroenterol Peru 20: 111–116.
-
18.
Passos-Castilho AM , Reinaldo MR , de Sena A , Granato CFH , 2017. High prevalence of hepatitis E virus antibodies in Sao Paulo, southeastern Brazil: Analysis of a group of blood donors representative of the general population. Braz J Infect Dis Off Publ Braz Soc Infect Dis 21: 535–539.
-
19.
Campolmi I et al., 2018. Seroprevalence of hepatitis A virus, hepatitis E virus, and Helicobacter pylori in rural communities of the Bolivian Chaco, 2013. Am J Trop Med Hyg 98: 1275–1280.
-
20.
Wallace SJ et al., 2017. Investigation of liver dysfunction: Who should we test for hepatitis E? Eur J Gastroenterol Hepatol 29: 215–220.
-
21.
Chandnani M , Kaur M , Ramadhas A , Tumarinson T , 2016. A case report about the most common yet most forgotten hepatitis E. Am J Case Rep 17: 584–586.
-
22.
Sarda P , Sharma SK , Mohan A , Makharia G , Jayaswal A , Pandey RM , Singh S , 2009. Role of acute viral hepatitis as a confounding factor in antituberculosis treatment induced hepatotoxicity. Indian J Med Res 129: 64–67.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1647 | 1515 | 548 |
| Full Text Views | 67 | 58 | 21 |
| PDF Downloads | 65 | 53 | 10 |