ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Buonfrate D et al., 2020. The global prevalence of Strongyloides stercoralis infection. Pathogens 9: 468.
-
2.
Laoraksawong P , Sanpool O , Rodpai R , Thanchomnang T , Kanarkard W , Maleewong W , Kraiklang R , Intapan PM , 2018. Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors. BMC Public Health 18: 940.
-
3.
Taylor MJ , Garrard TA , O’Donahoo FJ , Ross KE , 2014. Human strongyloidiasis: Identifying knowledge gaps, with emphasis on environmental control. Res Rep Trop Med 5: 55–63.
-
4.
Concha R , Harrington W Jr. , Rogers AI , 2005. Intestinal strongyloidiasis: Recognition, management, and determinants of outcome. J Clin Gastroenterol 39: 203–211.
-
5.
Gonzalez Canga A , Sahagun Prieto AM , Diez Liebana MJ , Fernandez Martinez N , Sierra Vega M , Garcia Vieitez JJ , 2008. The pharmacokinetics and interactions of ivermectin in humans—A mini-review. AAPS J 10: 42–46.
-
6.
Hailu T , Nibret E , Amor A , Munshea A , Anegagrie M , 2020. Efficacy of single dose ivermectin against Strongyloides stercoralis infection among primary school children in Amhara National Regional State. Infect Dis (Auckl) 13: 1178633720932544.
-
7.
Keidane D , Klavina A , Bergmane MB , Kovalcuka L , 2022. Parasitofauna and current status of anthelmintic resistance in Latvian sheep farms. Vet World 15: 414–418.
-
8.
Wolstenholme AJ , Fairweather I , Prichard R , von Samson-Himmelstjerna G , Sangster NC , 2004. Drug resistance in veterinary helminths. Trends Parasitol 20: 469–476.
-
9.
Sengthong C , Yingklang M , Intuyod K , Hongsrichan N , Pinlaor S , 2020. An optimized agar plate culture improves diagnostic efficiency for Strongyloides stercoralis infection in an endemic community. Parasitol Res 119: 1409–1413.
-
10.
Nontasut P , Muennoo C , Sa-nguankiat S , Fongsri S , Vichit A , 2005. Prevalence of Strongyloides in northern Thailand and treatment with ivermectin vs albendazole. Southeast Asian J Trop Med Public Health 36: 442–444.
-
11.
Adenusi AA , Oke AO , Adenusi AO , 2003. Comparison of ivermectin and thiabendazole in the treatment of uncomplicated human Strongyloides stercoralis infection. Afr J Biotechnol 2: 465–469.
-
12.
Toma H , Sato Y , Shiroma Y , Kobayashi J , Shimabukuro I , Takara M , 2000. Comparative studies on the efficacy of three anthelminthics on treatment of human strongyloidiasis in Okinawa, Japan. Southeast Asian J Trop Med Public Health 31: 147–151.
-
13.
Nutman TB , 2017. Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology 144: 263–273.
-
14.
Zaha O , Hirata T , Kinjo F , Saito A , Fukuhara H , 2002. Efficacy of ivermectin for chronic strongyloidiasis: Two single doses given 2 weeks apart. J Infect Chemother 8: 94–98.
-
15.
Buonfrate D et al., 2019. Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): A multicentre, open-label, phase 3, randomised controlled superiority trial. Lancet Infect Dis 19: 1181–1190.
-
16.
Uparanukraw P , Phongsri S , Morakote N , 1999. Fluctuations of larval excretion in Strongyloides stercoralis infection. Am J Trop Med Hyg 60: 967–973.
-
17.
Anamnart W , Pattanawongsa A , Intapan PM , Maleewong W , 2010. Albendazole stimulates the excretion of Strongyloides stercoralis larvae in stool specimens and enhances sensitivity for diagnosis of strongyloidiasis. J Clin Microbiol 48: 4216–4220.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1687 | 1468 | 398 |
| Full Text Views | 277 | 259 | 33 |
| PDF Downloads | 134 | 104 | 12 |
High Efficacy of Ivermectin for Strongyloidiasis Treatment
Chatchawan Sengthong
Chatchawan Sengthong
The Office of Disease Prevention and Control 7, Khon Kaen, Thailand;
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Somchai Pinlaor
Somchai Pinlaor
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Manachai Yingklang
Manachai Yingklang
Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand;
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Ornuma Haonon
Ornuma Haonon
Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand;
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Chanakan Jantawong
Chanakan Jantawong
Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand;
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Porntip Pinlaor
Porntip Pinlaor
Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
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Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
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Paiboon Sithithaworn
Paiboon Sithithaworn
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Nuttanan Hongsrichan
Nuttanan Hongsrichan
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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ABSTRACT.
Infection with Strongyloides stercoralis is often asymptomatic but can be life-threatening in immunocompromised patients, which can be prevented by ivermectin (IVM) treatment. The efficacy of IVM has been reported to have lessened over time in some regions as a consequence of prolonged use and mass treatment campaigns. Ivermectin has been used in Thailand for more than a decade; therefore, we investigated the efficacy of a single dose (200 µg/kg) of IVM against in asymptomatic strongyloidiasis in northeastern Thailand. Fecal samples were collected before and 2 weeks after treatment and were analyzed for the presence of Strongyloides using a modified agar plate culture and the formalin-ethyl acetate concentration technique. Our results showed that single-dose IVM treatment successfully eliminated S. stercoralis infection in asymptomatic individuals in the endemic area with a 100% cure rate, indicating the high efficacy of IVM treatment in strongyloidiasis in northeast Thailand.
Author Notes
Financial support: This study was supported by
Authors’ contributions: C. Sengthong: conceptualization, methodology; data curation; writing—original draft. S. Pinlaor: conceptualization, data curation; writing—original draft; funding acquisition. M. Yingklang, O. Haonon, C. Jantawong, P. Pinlaor: methodology; writing—review and editing. P. Sithithaworn: suggestions, writing—original draft, funding acquisition. N. Hongsrichan: supervision; conceptualization, data curation; suggestion, review and editing, writing—original draft.
Authors’ addresses: Chatchawan Sengthong, The Office of Disease Prevention and Control 7, Khon Kaen, Thailand, E-mail: chachasengthong@gmail.com. Somchai Pinlaor, and Nuttanan Hongsrichan, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, and Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mails: psomec@kku.ac.th, and nuttho@kku.ac.th. Manachai Yingklang, Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand, E-mail: manatao@gmail.com. Ornuma Haonon, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand, E-mail: grookae9@gmail.com. Chanakan Jantawong, Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand, E-mail: chanakan.jtw@gmail.com. Porntip Pinlaor, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand, and Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: porawa@kku.ac.th. Paiboon Sithithaworn, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: paibsit@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Buonfrate D et al., 2020. The global prevalence of Strongyloides stercoralis infection. Pathogens 9: 468.
-
2.
Laoraksawong P , Sanpool O , Rodpai R , Thanchomnang T , Kanarkard W , Maleewong W , Kraiklang R , Intapan PM , 2018. Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors. BMC Public Health 18: 940.
-
3.
Taylor MJ , Garrard TA , O’Donahoo FJ , Ross KE , 2014. Human strongyloidiasis: Identifying knowledge gaps, with emphasis on environmental control. Res Rep Trop Med 5: 55–63.
-
4.
Concha R , Harrington W Jr. , Rogers AI , 2005. Intestinal strongyloidiasis: Recognition, management, and determinants of outcome. J Clin Gastroenterol 39: 203–211.
-
5.
Gonzalez Canga A , Sahagun Prieto AM , Diez Liebana MJ , Fernandez Martinez N , Sierra Vega M , Garcia Vieitez JJ , 2008. The pharmacokinetics and interactions of ivermectin in humans—A mini-review. AAPS J 10: 42–46.
-
6.
Hailu T , Nibret E , Amor A , Munshea A , Anegagrie M , 2020. Efficacy of single dose ivermectin against Strongyloides stercoralis infection among primary school children in Amhara National Regional State. Infect Dis (Auckl) 13: 1178633720932544.
-
7.
Keidane D , Klavina A , Bergmane MB , Kovalcuka L , 2022. Parasitofauna and current status of anthelmintic resistance in Latvian sheep farms. Vet World 15: 414–418.
-
8.
Wolstenholme AJ , Fairweather I , Prichard R , von Samson-Himmelstjerna G , Sangster NC , 2004. Drug resistance in veterinary helminths. Trends Parasitol 20: 469–476.
-
9.
Sengthong C , Yingklang M , Intuyod K , Hongsrichan N , Pinlaor S , 2020. An optimized agar plate culture improves diagnostic efficiency for Strongyloides stercoralis infection in an endemic community. Parasitol Res 119: 1409–1413.
-
10.
Nontasut P , Muennoo C , Sa-nguankiat S , Fongsri S , Vichit A , 2005. Prevalence of Strongyloides in northern Thailand and treatment with ivermectin vs albendazole. Southeast Asian J Trop Med Public Health 36: 442–444.
-
11.
Adenusi AA , Oke AO , Adenusi AO , 2003. Comparison of ivermectin and thiabendazole in the treatment of uncomplicated human Strongyloides stercoralis infection. Afr J Biotechnol 2: 465–469.
-
12.
Toma H , Sato Y , Shiroma Y , Kobayashi J , Shimabukuro I , Takara M , 2000. Comparative studies on the efficacy of three anthelminthics on treatment of human strongyloidiasis in Okinawa, Japan. Southeast Asian J Trop Med Public Health 31: 147–151.
-
13.
Nutman TB , 2017. Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology 144: 263–273.
-
14.
Zaha O , Hirata T , Kinjo F , Saito A , Fukuhara H , 2002. Efficacy of ivermectin for chronic strongyloidiasis: Two single doses given 2 weeks apart. J Infect Chemother 8: 94–98.
-
15.
Buonfrate D et al., 2019. Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): A multicentre, open-label, phase 3, randomised controlled superiority trial. Lancet Infect Dis 19: 1181–1190.
-
16.
Uparanukraw P , Phongsri S , Morakote N , 1999. Fluctuations of larval excretion in Strongyloides stercoralis infection. Am J Trop Med Hyg 60: 967–973.
-
17.
Anamnart W , Pattanawongsa A , Intapan PM , Maleewong W , 2010. Albendazole stimulates the excretion of Strongyloides stercoralis larvae in stool specimens and enhances sensitivity for diagnosis of strongyloidiasis. J Clin Microbiol 48: 4216–4220.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1687 | 1468 | 398 |
| Full Text Views | 277 | 259 | 33 |
| PDF Downloads | 134 | 104 | 12 |