High Efficacy of Ivermectin for Strongyloidiasis Treatment

Chatchawan Sengthong The Office of Disease Prevention and Control 7, Khon Kaen, Thailand;

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Somchai Pinlaor Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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Manachai Yingklang Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand;

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Ornuma Haonon Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand;

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Chanakan Jantawong Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand;

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Porntip Pinlaor Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand

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Paiboon Sithithaworn Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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Nuttanan Hongsrichan Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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ABSTRACT.

Infection with Strongyloides stercoralis is often asymptomatic but can be life-threatening in immunocompromised patients, which can be prevented by ivermectin (IVM) treatment. The efficacy of IVM has been reported to have lessened over time in some regions as a consequence of prolonged use and mass treatment campaigns. Ivermectin has been used in Thailand for more than a decade; therefore, we investigated the efficacy of a single dose (200 µg/kg) of IVM against in asymptomatic strongyloidiasis in northeastern Thailand. Fecal samples were collected before and 2 weeks after treatment and were analyzed for the presence of Strongyloides using a modified agar plate culture and the formalin-ethyl acetate concentration technique. Our results showed that single-dose IVM treatment successfully eliminated S. stercoralis infection in asymptomatic individuals in the endemic area with a 100% cure rate, indicating the high efficacy of IVM treatment in strongyloidiasis in northeast Thailand.

Author Notes

Financial support: This study was supported by Research and Graduate Studies, Khon Kaen University (RP66-4-003). S. Pinlaor acknowledges research funds from Thailand Science Research and Innovation (TSRI), through Program Management Unit for Competitiveness (PMUC), number C10F630030 and CKDNET (grant no. CKDNET2559007). P. Sithithaworn was supported by National Research Council of Thailand.

Authors’ contributions: C. Sengthong: conceptualization, methodology; data curation; writing—original draft. S. Pinlaor: conceptualization, data curation; writing—original draft; funding acquisition. M. Yingklang, O. Haonon, C. Jantawong, P. Pinlaor: methodology; writing—review and editing. P. Sithithaworn: suggestions, writing—original draft, funding acquisition. N. Hongsrichan: supervision; conceptualization, data curation; suggestion, review and editing, writing—original draft.

Authors’ addresses: Chatchawan Sengthong, The Office of Disease Prevention and Control 7, Khon Kaen, Thailand, E-mail: chachasengthong@gmail.com. Somchai Pinlaor, and Nuttanan Hongsrichan, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, and Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mails: psomec@kku.ac.th, and nuttho@kku.ac.th. Manachai Yingklang, Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand, E-mail: manatao@gmail.com. Ornuma Haonon, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand, E-mail: grookae9@gmail.com. Chanakan Jantawong, Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand, E-mail: chanakan.jtw@gmail.com. Porntip Pinlaor, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand, and Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: porawa@kku.ac.th. Paiboon Sithithaworn, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: paibsit@gmail.com.

Address correspondence to Nuttanan Hongsrichan, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. E-mail: nuttho@kku.ac.th
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