Authors:
, , , , , , , , , , , , , , , , , and
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-
1.
Shin JH , Kim DI , Kim HR , Kim DS , Kook JK , Lee JN , 2007. Severe infective endocarditis of native valves caused by Weissella confusa detected incidentally on echocardiography. J Infect 54: e149–e151.
-
2.
Lee W , Cho SM , Kim M , Ko YG , Yong D , Lee K , 2013. Weissella confusa bacteremia in an immune-competent patient with underlying intramural hematomas of the aorta. Ann Lab Med 33: 459–462.
-
3.
Fusco V , Quero GM , Cho GS , Kabisch J , Meske D , Neve H , Bockelmann W , Franz CM , 2015. The genus Weissella: Taxonomy, ecology and biotechnological potential. Front Microbiol 6: 155.
-
4.
Kamboj K , Vasquez A , Balada-Llasat JM , 2015. Identification and significance of Weissella species infections. Front Microbiol 6: 1204.
-
5.
Ahmed S , Singh S , Singh V , Roberts KD , Zaidi A , Rodriguez-Palacios A , 2022. The Weissella genus: Clinically treatable bacteria with antimicrobial/probiotic effects on inflammation and cancer. Microorganisms 10: 2427.
-
6.
Kulwichit W , Nilgate S , Chatsuwan T , Krajiw S , Unhasuta C , Chongthaleong A , 2007. Accuracies of Leuconostoc phenotypic identification: A comparison of API systems and conventional phenotypic assays. BMC Infect Dis 7: 69.
-
7.
Kumar A , Augustine D , Sudhindran S , Kurian AM , Dinesh KR , Karim S , Philip R , 2011. Weissella confusa: A rare cause of vancomycin-resistant gram-positive bacteraemia. J Med Microbiol 60: 1539–1541.
-
8.
Fairfax MR , Lephart PR , Salimnia H , 2014. Weissella confusa: Problems with identification of an opportunistic pathogen that has been found in fermented foods and proposed as a probiotic. Front Microbiol 5: 254.
-
9.
Lee MR , Huang YT , Liao CH , Lai CC , Lee PI , Hsueh PR , 2011. Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997–2007. Clin Microbiol Infect 17: 1226–1231.
-
10.
Flaherty JD , Levett PN , Dewhirst FE , Troe TE , Warren JR , Johnson S , 2003. Fatal case of endocarditis due to Weissella confusa. J Clin Microbiol 41: 2237–2239.
-
11.
Salimnia H , Alangaden GJ , Bharadwaj R , Painter TM , Chandrasekar PH , Fairfax MR , 2011. Weissella confusa: An unexpected cause of vancomycin-resistant gram-positive bacteremia in immunocompromised hosts. Transpl Infect Dis 13: 294–298.
-
12.
Olano A , Chua J , Schroeder S , Minari A , La Salvia M , Hall G , 2001. Weissella confusa (basonym: Lactobacillus confusus) bacteremia: A case report. J Clin Microbiol 39: 1604–1607.
-
13.
Harlan NP , Kempker RR , Parekh SM , Burd EM , Kuhar DT , 2011. Weissella confusa bacteremia in a liver transplant patient with hepatic artery thrombosis. Transpl Infect Dis 13: 290–293.
-
14.
Medford R , Patel SN , Evans GA , 2014. A confusing case – Weissella confusa prosthetic joint infection: A case report and review of the literature. Can J Infect Dis Med Microbiol 25: 173–175.
-
15.
Vasquez A , Pancholi P , Balada-Llasat JM , 2015. Photo quiz: Confusing bacteremia in a Crohn’s disease patient. Weissella confusa. J Clin Microbiol 53: 103595.
-
16.
Spiegelhauer MR , Yusibova M , Rasmussen IKB , Fuglsang KA , Thomsen K , Andersen LP , 2020. A case report of polymicrobial bacteremia with Weissella confusa and comparison of previous treatment for successful recovery with a review of the literature. Access Microbiol 2: acmi000119.
-
17.
Fhoula I , Boumaiza M , Tayh G , Rehaiem A , Klibi N , Ouzari IH , 2022. Antimicrobial activity and safety features assessment of Weissella spp. from environmental sources. Food Sci Nutr 10: 2896–2910.
-
18.
El-Mekkawy RM , Hamour NE , Hassanein WA , Allam AA , 2023. Evaluation of the antibacterial activity of Weissella confusa K3 cell-free supernatant against extended-spectrum βeta lactamase (ESBL) producing uropathogenic Escherichia coli U60. Saudi J Biol Sci 30: 103595.
-
19.
Azim A , Singh N , Venkatesh V , Verma S , Agarwal A , 2023. Weissella confusa causing vancomycin-resistant septicemia infection in a pediatric patient: A case report from a university teaching hospital in North India. Cureus 15: e38292.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 1312 | 1313 | 155 |
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Characterization of Weissella Species during a 3-Year Observational Study – An Emerging Threat
Ashima Jamwal
Ashima Jamwal
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Gerlin Varghese
Gerlin Varghese
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Deepika Sarawat
Deepika Sarawat
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Nidhi Tejan
Nidhi Tejan
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Sangram Singh Patel
Sangram Singh Patel
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Chinmoy Sahu
Chinmoy Sahu
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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ABSTRACT.
Weissella species are mistaken for Lactobacillus or Leuconostoc because of their Gram-staining property and resistance to vancomycin. In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four–hour growth from a positive blood culture or CSF sample was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Demographic and clinical details of the patients were extracted from the hospital information system. Kirby-Bauer disk diffusion was used for antibiotic susceptibility testing. During the 3-year study, 13 isolates of Weissella species were identified in our laboratory. Among the patients, male predominance was seen. The age range of the patients was 5–53 years. The samples were blood samples (n = 11) and CSF samples (n = 2). Of these isolates, 12 (92.3%) were identified as Weissella confusa and 1 (7.69%) was identified as Weissella viridescens. Common risk factors were anemia, prolonged hospital stay, indwelling catheter, chemotherapy, and chronic kidney disease. All the isolates in this study were sensitive to amikacin, daptomycin, amoxicillin-clavulanate, minocycline, and linezolid. Death was attributed to Weissella infection in three patients. Weissella species are opportunistic organisms that need to be identified quickly and precisely to guarantee the right course of treatment.
Author Notes
Disclosure: All authors have agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Authors’ contributions: A. Jamwal: conception of work and data acquisition. G. Varghese: data curation and clinical data collection. D. Sarawat: data analysis. S. S. Patel: revising the draft critically for important intellectual content. N. Tejan: data analysis. C. Sahu: final approval of the version to be published.
Authors’ addresses: Ashima Jamwal, Gerlin Varghese, Deepika Sarawat, Nidhi Tejan, Sangram Singh Patel, and Chinmoy Sahu, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, E-mails: ashi.jamwal@gmail.com, gerlinvarghese20@gmail.com, docdeepika14@gmail.com, nidhiresearchsgpgi@gmail.com, sangramresearch968@gmail.com, and chinmoyresearch@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Shin JH , Kim DI , Kim HR , Kim DS , Kook JK , Lee JN , 2007. Severe infective endocarditis of native valves caused by Weissella confusa detected incidentally on echocardiography. J Infect 54: e149–e151.
-
2.
Lee W , Cho SM , Kim M , Ko YG , Yong D , Lee K , 2013. Weissella confusa bacteremia in an immune-competent patient with underlying intramural hematomas of the aorta. Ann Lab Med 33: 459–462.
-
3.
Fusco V , Quero GM , Cho GS , Kabisch J , Meske D , Neve H , Bockelmann W , Franz CM , 2015. The genus Weissella: Taxonomy, ecology and biotechnological potential. Front Microbiol 6: 155.
-
4.
Kamboj K , Vasquez A , Balada-Llasat JM , 2015. Identification and significance of Weissella species infections. Front Microbiol 6: 1204.
-
5.
Ahmed S , Singh S , Singh V , Roberts KD , Zaidi A , Rodriguez-Palacios A , 2022. The Weissella genus: Clinically treatable bacteria with antimicrobial/probiotic effects on inflammation and cancer. Microorganisms 10: 2427.
-
6.
Kulwichit W , Nilgate S , Chatsuwan T , Krajiw S , Unhasuta C , Chongthaleong A , 2007. Accuracies of Leuconostoc phenotypic identification: A comparison of API systems and conventional phenotypic assays. BMC Infect Dis 7: 69.
-
7.
Kumar A , Augustine D , Sudhindran S , Kurian AM , Dinesh KR , Karim S , Philip R , 2011. Weissella confusa: A rare cause of vancomycin-resistant gram-positive bacteraemia. J Med Microbiol 60: 1539–1541.
-
8.
Fairfax MR , Lephart PR , Salimnia H , 2014. Weissella confusa: Problems with identification of an opportunistic pathogen that has been found in fermented foods and proposed as a probiotic. Front Microbiol 5: 254.
-
9.
Lee MR , Huang YT , Liao CH , Lai CC , Lee PI , Hsueh PR , 2011. Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997–2007. Clin Microbiol Infect 17: 1226–1231.
-
10.
Flaherty JD , Levett PN , Dewhirst FE , Troe TE , Warren JR , Johnson S , 2003. Fatal case of endocarditis due to Weissella confusa. J Clin Microbiol 41: 2237–2239.
-
11.
Salimnia H , Alangaden GJ , Bharadwaj R , Painter TM , Chandrasekar PH , Fairfax MR , 2011. Weissella confusa: An unexpected cause of vancomycin-resistant gram-positive bacteremia in immunocompromised hosts. Transpl Infect Dis 13: 294–298.
-
12.
Olano A , Chua J , Schroeder S , Minari A , La Salvia M , Hall G , 2001. Weissella confusa (basonym: Lactobacillus confusus) bacteremia: A case report. J Clin Microbiol 39: 1604–1607.
-
13.
Harlan NP , Kempker RR , Parekh SM , Burd EM , Kuhar DT , 2011. Weissella confusa bacteremia in a liver transplant patient with hepatic artery thrombosis. Transpl Infect Dis 13: 290–293.
-
14.
Medford R , Patel SN , Evans GA , 2014. A confusing case – Weissella confusa prosthetic joint infection: A case report and review of the literature. Can J Infect Dis Med Microbiol 25: 173–175.
-
15.
Vasquez A , Pancholi P , Balada-Llasat JM , 2015. Photo quiz: Confusing bacteremia in a Crohn’s disease patient. Weissella confusa. J Clin Microbiol 53: 103595.
-
16.
Spiegelhauer MR , Yusibova M , Rasmussen IKB , Fuglsang KA , Thomsen K , Andersen LP , 2020. A case report of polymicrobial bacteremia with Weissella confusa and comparison of previous treatment for successful recovery with a review of the literature. Access Microbiol 2: acmi000119.
-
17.
Fhoula I , Boumaiza M , Tayh G , Rehaiem A , Klibi N , Ouzari IH , 2022. Antimicrobial activity and safety features assessment of Weissella spp. from environmental sources. Food Sci Nutr 10: 2896–2910.
-
18.
El-Mekkawy RM , Hamour NE , Hassanein WA , Allam AA , 2023. Evaluation of the antibacterial activity of Weissella confusa K3 cell-free supernatant against extended-spectrum βeta lactamase (ESBL) producing uropathogenic Escherichia coli U60. Saudi J Biol Sci 30: 103595.
-
19.
Azim A , Singh N , Venkatesh V , Verma S , Agarwal A , 2023. Weissella confusa causing vancomycin-resistant septicemia infection in a pediatric patient: A case report from a university teaching hospital in North India. Cureus 15: e38292.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1312 | 1313 | 155 |
| Full Text Views | 206 | 206 | 22 |
| PDF Downloads | 45 | 45 | 1 |