ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Franco-Paredes C , Marcos LA , Henao-Martínez AF , Rodríguez-Morales AJ , Vilamil-Gómez WE , Gotuzzo E , Bonifaz A , 2018. Cutaneous mycobacterial infections. Clin Microbiol Rev 32: e00069–18.
-
2.
Hill MK , Sanders CV , 2017. Cutaneous tuberculosis. Microbiol Spectr 5. doi: 10.1128/microbiolspec.TNMI7-0010-2016.
-
3.
Mohta S , Kumar A , Singh N , Wig N , 2017. A case of tuberculous gumma: There is more to it than meets the eye. BMJ Case Rep 2017: bcr2017221701.
-
4.
Charifa A , Mangat R , Oakley AM , 2022. Cutaneous tuberculosis. In: StatPearls. Treasure Island, FL: StatPearls Publishing.
-
5.
Lange C , Aaby P , Behr MA , Donald PR , Kaufmann SHE , Betea MG , Mandalakas AM , 2022. 100 years of Mycobacterium bovis bacille Calmette–Guérin. Lancet Infect Dis 22: e2–e12.
-
6.
Kaul S , Kaur I , Mehta S , Singal A , 2023. Cutaneous tuberculosis. Part I: Pathogenesis, classification, and clinical features. J Am Acad Dermatol 89: 1091–1103.
-
7.
Khadka P , Koirala S , Thapaliya J , 2018. Cutaneous tuberculosis: Clinicopathologic arrays and diagnostic challenges. Dermatol Res Pract 2018: 7201973.
-
8.
Inoue T , Fukumoto T , Ansai S , Kimura T , 2006. Erythema induratum of Bazin in an infant after bacille Calmette–Guerin vaccination. J Dermatol 33: 268–272.
-
9.
Machan A , Hanafi T , Hjira N , Boui M , 2018. Tuberculous gummas: Epidemiological, clinical, bacteriological, immunological, and therapeutic features. Int J Mycobacteriol 7: 203–211.
-
10.
Dekeyzer S , Moerman F , Callens S , Vandekerckhove L , 2013. Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis. Acta Clin Belg 68: 34–36.
-
11.
Paccoud O , Monsel G , Calin R , Caumes E , Pourcher V , 2018. Tuberculous gumma-like paradoxical cutaneous reaction in a heart transplant recipient. Med Mal Infect 48: 554–556.
-
12.
Alam MA , Ahmed MN , Khan AH , Arafat SM , 2021. Metastatic tuberculous abscess: A rare manifestation of cutaneous tuberculosis. IDCases 26: e01257.
-
13.
Isoletta E , Ciolfi C , Bonometti A , Sachs M , Brazzelli V , 2022. An atypical presentation of tuberculous gumma heralding a diagnosis of lymph node tuberculosis: Hindsight is 20/20. JAAD Case Rep 24: 14–17.
-
14.
Azendour H , Meziane M , Znati K , Benzekri L , Senouci K , 2021. A polymorphous cutaneous tuberculosis. Int J Mycobacteriol 10: 85–88.
-
15.
Bachmeyer C , Ammouri W , Moguelet P , Charoud A , Buot G , Grateau G , Caumes E , 2007. Abcès tuberculeux métastatiques (gommes tuberculeuses): Un diagnostic rare en France [Metastatic tubercular abscesses (tuberculous gumma): an unusual diagnosis in France]. Ann Dermatol Venereol 134: 49–52.
-
16.
Sezgin B , Atilganoglu U , Yigit O , Ergün SS , Cambaz N , Demirkesen C , 2008. Concomitant cutaneous metastatic tuberculous abscesses and multifocal skeletal tuberculosis. Indian J Dermatol 53: 149–153.
-
17.
Dash M , Sarangi R , Panda M , 2012. Generalized tuberculous gumma. Indian Pediatr 49: 773.
-
18.
Parker L , Babu S , 2013. Tuberculous gumma: A forgotten entity in the UK. BMJ Case Rep 2013: bcr2013010462.
-
19.
Vidal D , Barnadas M , Pérez M , Coll P , Alomar A , 2001. Tuberculous gumma following venepuncture. Br J Dermatol 144: 601–603.
-
20.
Mohta S , Kumar A , Singh N , Wig N , 2017. A case of tuberculous gumma: There is more to it than meets the eye. BMJ Case Rep 2017: 1–3.
-
21.
Difonzo EM , Lotti L , Salvini C , Sestini S , Fabroni C , 2006. Tuberculous gumma in a patient with cervical lymphadenitis. Int J Dermatol 45: 1467–1468.
-
22.
Maejima H , Arai S , Ebata T , Takeda H , Kusunoki M , Katsuoka K , 2007. Tuberculous gumma associated with idiopathic thrombocytopenic purpura: report of a Japanese female patient. J Dermatol 34: 86–91.
-
23.
Dekeyzer S , Moerman F , Callens S , Vandekerckhove L , 2013. Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis. Acta Clin Belg 68: 34–36.
-
24.
Matsuura-Otsuki Y , Hanafusa T , Igawa K , Sato H , Nishizawa A , Yokozeki H , 2016. Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still’s disease and Good’s syndrome. Eur J Dermatol 26: 309–311.
-
25.
Kato M , Shimizu A , Ishikawa O , 2014. Metastatic tuberculous abscess as a manifestation of miliary tuberculosis. J Dermatol 41: 1117–1118.
-
26.
Pacheco C , Silva E , Miranda J , Duarte R , 2015. Cutaneous tuberculosis as metastatic tuberculous abscess. J Bras Pneumol 41: 200–202.
-
27.
Almagro M , Del Pozo J , Rodríguez-Lozano J , Silva JG , Yebra-Pimentel MT , Fonseca E , 2005. Metastatic tuberculous abscesses in an immunocompetent patient. Clin Exp Dermatol 30: 247–249.
-
28.
Kalaria VG , Kapila R , Schwartz RA , 2000. Tuberculous gumma (cutaneous metastatic tuberculous abscess) with underlying lymphoma. Cutis 66: 277–279.
-
29.
Lakshmi TS , Rao AG , 2002. Multi focal tuberculosis. Indian J Dermatol Venereol Leprol 68: 358–359.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1687 | 1687 | 64 |
| Full Text Views | 52 | 52 | 1 |
| PDF Downloads | 68 | 68 | 1 |
Case Report: Clinical and Pathological Findings of Tuberculous Gumma: A Case Report and Literature Review
Li-Jia Deng
Li-Jia Deng
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
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Qian Ye
Qian Ye
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
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Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
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Si-Yu Luo
Si-Yu Luo
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Qin-Xiao Wang
Qin-Xiao Wang
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
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Sheng Fang
Sheng Fang
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
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ABSTRACT.
Tuberculous gumma (TG) is a rare type of cutaneous tuberculosis thought to occur as a result of the hematogenous spread of Mycobacterium tuberculosis, which is more common in immunosuppressed individuals. An 8-year-old boy presented with a 2-month history of multiple indolent enlarging ulcerated nodules on his left upper extremity. He had a past medical history of bacille Calmette–Guerin vaccine induced lupus vulgaris. Skin biopsy of the nodules showed granulomas and neutrophil-dominated purulent inflammation. Ziehl–Neelsen staining was negative, and the cultures were positive for M. tuberculosis. Furthermore, the M. tuberculosis complex was identified using metagenomic next-generation sequencing. Standard antitubercular therapy was started at full doses, and the skin lesions had significantly improved 3 months later. Here we review the literature since 2000 and describe the clinical and pathological features of TG.
Author Notes
Disclosure: Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. This is a retrospective case study. The First Affiliated Hospital Ethics Committee has confirmed that no ethical approval is required. The original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding authors.
Authors’ addresses: Li-Jia Deng, Si-Yu Luo, Qin-Xiao Wang, and Sheng Fang, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, E-mails: denglijiaderm@yeah.net; siyuluoderm@yeah.net; qinxiaowangderm@yeah.net; fangshengderm@163.com. Qian Ye, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China and Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, E-mail: yeqian0330@163.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Franco-Paredes C , Marcos LA , Henao-Martínez AF , Rodríguez-Morales AJ , Vilamil-Gómez WE , Gotuzzo E , Bonifaz A , 2018. Cutaneous mycobacterial infections. Clin Microbiol Rev 32: e00069–18.
-
2.
Hill MK , Sanders CV , 2017. Cutaneous tuberculosis. Microbiol Spectr 5. doi: 10.1128/microbiolspec.TNMI7-0010-2016.
-
3.
Mohta S , Kumar A , Singh N , Wig N , 2017. A case of tuberculous gumma: There is more to it than meets the eye. BMJ Case Rep 2017: bcr2017221701.
-
4.
Charifa A , Mangat R , Oakley AM , 2022. Cutaneous tuberculosis. In: StatPearls. Treasure Island, FL: StatPearls Publishing.
-
5.
Lange C , Aaby P , Behr MA , Donald PR , Kaufmann SHE , Betea MG , Mandalakas AM , 2022. 100 years of Mycobacterium bovis bacille Calmette–Guérin. Lancet Infect Dis 22: e2–e12.
-
6.
Kaul S , Kaur I , Mehta S , Singal A , 2023. Cutaneous tuberculosis. Part I: Pathogenesis, classification, and clinical features. J Am Acad Dermatol 89: 1091–1103.
-
7.
Khadka P , Koirala S , Thapaliya J , 2018. Cutaneous tuberculosis: Clinicopathologic arrays and diagnostic challenges. Dermatol Res Pract 2018: 7201973.
-
8.
Inoue T , Fukumoto T , Ansai S , Kimura T , 2006. Erythema induratum of Bazin in an infant after bacille Calmette–Guerin vaccination. J Dermatol 33: 268–272.
-
9.
Machan A , Hanafi T , Hjira N , Boui M , 2018. Tuberculous gummas: Epidemiological, clinical, bacteriological, immunological, and therapeutic features. Int J Mycobacteriol 7: 203–211.
-
10.
Dekeyzer S , Moerman F , Callens S , Vandekerckhove L , 2013. Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis. Acta Clin Belg 68: 34–36.
-
11.
Paccoud O , Monsel G , Calin R , Caumes E , Pourcher V , 2018. Tuberculous gumma-like paradoxical cutaneous reaction in a heart transplant recipient. Med Mal Infect 48: 554–556.
-
12.
Alam MA , Ahmed MN , Khan AH , Arafat SM , 2021. Metastatic tuberculous abscess: A rare manifestation of cutaneous tuberculosis. IDCases 26: e01257.
-
13.
Isoletta E , Ciolfi C , Bonometti A , Sachs M , Brazzelli V , 2022. An atypical presentation of tuberculous gumma heralding a diagnosis of lymph node tuberculosis: Hindsight is 20/20. JAAD Case Rep 24: 14–17.
-
14.
Azendour H , Meziane M , Znati K , Benzekri L , Senouci K , 2021. A polymorphous cutaneous tuberculosis. Int J Mycobacteriol 10: 85–88.
-
15.
Bachmeyer C , Ammouri W , Moguelet P , Charoud A , Buot G , Grateau G , Caumes E , 2007. Abcès tuberculeux métastatiques (gommes tuberculeuses): Un diagnostic rare en France [Metastatic tubercular abscesses (tuberculous gumma): an unusual diagnosis in France]. Ann Dermatol Venereol 134: 49–52.
-
16.
Sezgin B , Atilganoglu U , Yigit O , Ergün SS , Cambaz N , Demirkesen C , 2008. Concomitant cutaneous metastatic tuberculous abscesses and multifocal skeletal tuberculosis. Indian J Dermatol 53: 149–153.
-
17.
Dash M , Sarangi R , Panda M , 2012. Generalized tuberculous gumma. Indian Pediatr 49: 773.
-
18.
Parker L , Babu S , 2013. Tuberculous gumma: A forgotten entity in the UK. BMJ Case Rep 2013: bcr2013010462.
-
19.
Vidal D , Barnadas M , Pérez M , Coll P , Alomar A , 2001. Tuberculous gumma following venepuncture. Br J Dermatol 144: 601–603.
-
20.
Mohta S , Kumar A , Singh N , Wig N , 2017. A case of tuberculous gumma: There is more to it than meets the eye. BMJ Case Rep 2017: 1–3.
-
21.
Difonzo EM , Lotti L , Salvini C , Sestini S , Fabroni C , 2006. Tuberculous gumma in a patient with cervical lymphadenitis. Int J Dermatol 45: 1467–1468.
-
22.
Maejima H , Arai S , Ebata T , Takeda H , Kusunoki M , Katsuoka K , 2007. Tuberculous gumma associated with idiopathic thrombocytopenic purpura: report of a Japanese female patient. J Dermatol 34: 86–91.
-
23.
Dekeyzer S , Moerman F , Callens S , Vandekerckhove L , 2013. Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis. Acta Clin Belg 68: 34–36.
-
24.
Matsuura-Otsuki Y , Hanafusa T , Igawa K , Sato H , Nishizawa A , Yokozeki H , 2016. Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still’s disease and Good’s syndrome. Eur J Dermatol 26: 309–311.
-
25.
Kato M , Shimizu A , Ishikawa O , 2014. Metastatic tuberculous abscess as a manifestation of miliary tuberculosis. J Dermatol 41: 1117–1118.
-
26.
Pacheco C , Silva E , Miranda J , Duarte R , 2015. Cutaneous tuberculosis as metastatic tuberculous abscess. J Bras Pneumol 41: 200–202.
-
27.
Almagro M , Del Pozo J , Rodríguez-Lozano J , Silva JG , Yebra-Pimentel MT , Fonseca E , 2005. Metastatic tuberculous abscesses in an immunocompetent patient. Clin Exp Dermatol 30: 247–249.
-
28.
Kalaria VG , Kapila R , Schwartz RA , 2000. Tuberculous gumma (cutaneous metastatic tuberculous abscess) with underlying lymphoma. Cutis 66: 277–279.
-
29.
Lakshmi TS , Rao AG , 2002. Multi focal tuberculosis. Indian J Dermatol Venereol Leprol 68: 358–359.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1687 | 1687 | 64 |
| Full Text Views | 52 | 52 | 1 |
| PDF Downloads | 68 | 68 | 1 |