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Gong QL et al., 2021. Meta-analysis of the prevalence of Echinococcus in dogs in China from 2010 to 2019. PLoS Negl Trop Dis 15: e0009268.
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Liu L et al., 2018. Geographic distribution of echinococcosis in Tibetan region of Sichuan Province, China. Infect Dis Poverty 7: 1101–1109.
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| Past two years | Past Year | Past 30 Days | |
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Epidemiology and Clinical Characteristics of Cerebral Alveolar Echinococcosis in the Tibetan Region of Sichuan, China
Tao Li
Tao Li
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China;
Department of Neurosurgery, Shifang Traditional Chinese Medicine Hospital, Shifang, China;
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Department of Neurosurgery, Shifang Traditional Chinese Medicine Hospital, Shifang, China;
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Wei Zhang
Wei Zhang
Department of Neurosurgery, People’s Hospital of Garze Tibetan Autonomous Prefecture, Kangding, China
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Liangwei Shen
Liangwei Shen
Department of Neurosurgery, People’s Hospital of Garze Tibetan Autonomous Prefecture, Kangding, China
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Xiang Wang
Xiang Wang
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China;
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ABSTRACT.
This study aimed to examine the epidemiology and clinical characteristics of cerebral alveolar echinococcosis in the Tibetan region of Sichuan, China. A retrospective analysis of hospitalized cases of cerebral alveolar echinococcosis from six medical units in the Garze Tibetan Autonomous Prefecture, Sichuan Province, from January 2016 to June 2021 was conducted. The study focused on the characteristics, clinical presentation, and imaging features of the disease. Of 119 cerebral alveolar echinococcosis patients, 76 were male and 43 were female. Occupationally, 62 were farmers, 46 were herdsmen, nine were monks, and two were students. The mean age was 43.9 (± 13.9) years. The primary clinical manifestations were dizziness, headaches, and epilepsy. The incidence of cerebral alveolar echinococcosis was most concentrated within 4 years after the diagnosis of hepatic alveolar echinococcosis (77/119, 64.7%). There were 86 cases (72.3%) with multiple intracranial echinococcosis lesions, with an average size of 2.0 cm × 2.5 cm. The imaging features showed that the lesion was mainly concentrated in the anterior circulation blood supply area, and the lesion had multiple aggregated small vesicular structures as its unique imaging feature. Among 98 follow-up cases, 62 could live independently (63.3%); 18 deaths were recorded (18.4%), with an approximate 5-year survival rate of 81.6%. Regular examination of patients with first diagnosis of hepatic alveolar echinococcosis without a combination of echinococcosis in other parts of the body can help monitor and prevent the occurrence of cerebral alveolar echinococcosis, improve the understanding of cerebral alveolar echinococcosis in Tibetan areas of Sichuan.
Author Notes
Disclosure: The study complied with the ethical requirements of China’s major control programs, such as the central financial subsidy for echinococcosis, and obtained the informed consent of the investigator.
Authors’ contributions: T. Li: conceptualization, data curation, writing—original draft, visualization. W. Zhang: formal analysis, writing—review and editing. L. Shen: resources. X. Wang: conceptualization, writing—review & editing, supervision.
Authors’ addresses: Tao Li, Shifang Traditional Chinese Medicine Hospital, Shifang, China, E-mail: xl1990lt@163.com. Xiang Wang, West China Hospital, Sichuan University, Chengdu, China, E-mail: wangxiangtim@gmail.com. Wei Zhang and Liangwei Shen, People’s Hospital of Garze Tibetan Autonomous Prefecture, Sichuan, China, E-mails: 791469430@qq.com and 630286668@qq.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Fu MH , Wang X , Han S , Guan YY , Bergquist R , Wu WP , 2021. Advances in research on echinococcoses epidemiology in China. Acta Trop 219: 105921.
-
2.
Gong QL et al., 2021. Meta-analysis of the prevalence of Echinococcus in dogs in China from 2010 to 2019. PLoS Negl Trop Dis 15: e0009268.
-
3.
Liu L et al., 2018. Geographic distribution of echinococcosis in Tibetan region of Sichuan Province, China. Infect Dis Poverty 7: 1101–1109.
-
4.
Svrckova P , Nabarro L , Chiodini PL , Jäger HR , 2019. Disseminated cerebral hydatid disease (multiple intracranial echinococcosis). Pract Neurol 19: 156–163.
-
5.
Abbasi B , Akhavan R , Ghamari Khameneh A , Darban Hosseini Amirkhiz G , Rezaei-Dalouei H , Tayebi S , Hashemi J , Aminizadeh B , Darban Hosseini Amirkhiz S , 2021. Computed tomography and magnetic resonance imaging of hydatid disease: A pictorial review of uncommon imaging presentations. Heliyon 7: e07086.
-
6.
Du G , Li Y , Wu P , Wang X , Su R , Fan Y , Geng D , 2021. Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis. Chinese Neurosurg J 7: 30.
-
7.
Wen H , Vuitton L , Tuxun T , Li J , Vuitton DA , Zhang W , McManus DP , 2019. Echinococcosis: Advances in the 21st century. Clin Microbiol Rev 32: e00075-18.
-
8.
Takci E , Sengul G , Akar A , Uslu H , Alper F , Erdogan F , Aydin IH , 2008. Alveolar echinococcosis of the brain in five patients. J Clin Neurosci 15: 1105–1109.
-
9.
He W et al., 2021. Prevalence and spatial distribution patterns of human echinococcosis at the township level in Sichuan Province, China. Infect Dis Poverty 10: 82.
-
10.
Gottstein B , Wang J , Boubaker G , Marinova I , Spiliotis M , Müller N , Hemphill A , 2015. Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis). Vet Parasitol 213: 103–109.
-
11.
Bai Y et al., 2020. Dynamic changes in the global transcriptome and microRNAome reveal complex miRNA–mRNA regulation in early stages of the bi-directional development of Echinococcus granulosus protoscoleces. Front Microbiol 11: 654.
-
12.
Li S et al., 2021. Clinical features, radiological characteristics, and outcomes of patients with intracranial alveolar echinococcosis: A case series from Tibetan areas of Sichuan Province, China. Front Neurol 11: 537565.
-
13.
Kadry Z , Renner EC , Bachmann LM , Attigah N , Renner EL , Ammann RW , Clavien PA , 2005. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg 92: 1110–1116.
-
14.
Woolsey ID , Miller AL , 2021. Echinococcus granulosus sensu lato and Echinococcus multilocularis: A review. Res Vet Sci 135: 517–522.
-
15.
Yu Q , Xiao N , Han S , Tian T , Zhou XN , 2020. Progress on the national echinococcosis control programme in China: Analysis of humans and dogs population intervention during 2004–2014. Infect Dis Poverty 9: 137.
-
16.
Wang Q et al., 2014. Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: A prospective for control options. Infect Dis Poverty 3: 3.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1391 | 932 | 72 |
| Full Text Views | 86 | 44 | 4 |
| PDF Downloads | 85 | 51 | 4 |