ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Engel J , 2001. Mesial temporal lobe epilepsy: what have we learned? Neuroscientist 7: 340–352.
-
2.
Wieser H-G , 2004. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 45: 20.
-
3.
Jobst BC , Cascino GD , 2015. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA 313: 285.
-
4.
Josephson CB , Dykeman J , Fiest KM , Liu X , Sadler RM , Jette N , Wiebe S , 2013. Systematic review and meta-analysis of standard vs selective temporal lobe epilepsy surgery. Neurology 80: 1669–1676.
-
5.
Velasco TR , 2006. Calcified cysticercotic lesions and intractable epilepsy: a cross sectional study of 512 patients. J Neurol Neurosurg Psychiatry 77: 485–488.
-
6.
Singla M , Singh P , Kaushal S , Bansal R , Singh G , 2007. Hippocampal sclerosis in association with neurocysticercosis. Epileptic Disord 9: 8.
-
7.
Secchi TL , Brondani R , Bragatti JA , Bizzi JWJ , Bianchin MM , 2022. Evaluating the association of calcified neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis in a large cohort of patients with epilepsy. Front Neurol 12: 769356.
-
8.
Sánchez SS et al., 2022. Hippocampal atrophy/sclerosis is associated with old, calcified parenchymal brain neurocysticercosis, but not with more recent, viable infections. Am J Trop Med Hyg 106: 215–218.
-
9.
Gupta RK , Awasthi R , Rathore RK , Verma A , Sahoo P , Paliwal VK , Prasad KN , Pandey CM , Narayana PA , 2012. Understanding epileptogenesis in calcified neurocysticercosis with perfusion MRI. Neurology 78: 618–625.
-
10.
Debacq G , Moyano LM , Garcia HH , Boumediene F , Marin B , Ngoungou EB , Preux PM , 2017. Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. PLoS Negl Trop Dis 11: e0005153.
-
11.
Montano SM et al., 2005. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology 65: 229–233.
-
12.
Rajshekhar V , Raghava MV , Prabhakaran V , Oommen A , Muliyil J , 2006. Active epilepsy as an index of burden of neurocysticercosis in Vellore district, India. Neurology 67: 2135–2139.
-
13.
Del Brutto OH , Arroyo G , Del Brutto VJ , Zambrano M , García HH , 2017. On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: a large‐scale, computed tomography–based population study in rural Ecuador. Epilepsia 58: 1955–1961.
-
14.
Nash TE , Pretell EJ , Lescano AG , Bustos JA , Gilman RH , Gonzalez AE , Garcia HH ; Cysticercosis Working Group in Peru , 2008. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case–control study. Lancet Neurol 7: 1099–1105.
-
15.
Kwan P , Arzimanoglou A , Berg AT , Brodie MJ , Allen Hauser W , Mathern G , Moshé SL , Perucca E , Wiebe S , French J , 2009. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies: definition of drug resistant epilepsy. Epilepsia 51: 1069–1077.
-
16.
Blümcke I et al., 2013. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia 54: 1315–1329.
-
17.
Blumcke I et al., 2017. Histopathological findings in brain tissue obtained during epilepsy surgery. N Engl J Med 377: 1648–1656.
-
18.
Engel J Jr., Van NP, Rasmussen TB, Ojemann LM, 1993. Outcome with respect to epileptic seizures. Engel J Jr., ed. Surgical Treatment of the Epilepsies. 2nd ed. New York: Raven Press, 609–621
-
19.
Del Brutto OH , 2020. Twenty-five years of evolution of standard diagnostic criteria for neurocysticercosis. How have they impacted diagnosis and patient outcomes? Expert Rev Neurother 20: 147–155.
-
20.
Bianchin MM , Velasco TR , Wichert-Ana L , dos Santos AC , Sakamoto AC , 2017. Understanding the association of neurocysticercosis and mesial temporal lobe epilepsy and its impact on the surgical treatment of patients with drug-resistant epilepsy. Epilepsy Behav 76: 168–177.
-
21.
De Oliveira Taveira M , Morita ME , Yasuda CL , Coan AC , Secolin R , Luiz Cunha da Costa A , Cendes F , 2015. Neurocysticercotic calcifications and hippocampal sclerosis: a case-control study. PLoS One 10: e0131180.
-
22.
Oliveira MCB , Martin MGM , Tsunemi MH , Vieira G , Castro LHM , 2014. Small calcified lesions suggestive of neurocysticercosis are associated with mesial temporal sclerosis. Arq Neuropsiquiatr 72: 510–516.
-
23.
Meguins LC , Adry RA , Silva Júnior SC , Pereira CU , Oliveira JG , Morais DF , Araújo Filho GM , Marques LH , 2015. Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis. Arq Neuropsiquiatr 73: 1014–1018.
-
24.
Chandra PS , Bal C , Garg A , Gaikwad S , Prasad K , Sharma BS , Sarkar C , Singh MB , Padma VM , Tripathi M , 2010. Surgery for medically intractable epilepsy due to postinfectious etiologies: Epilepsy Surgery for Postinfectious Etiologies. Epilepsia 51: 1097–1100.
-
25.
Tatum WO , 2012. Mesial temporal lobe epilepsy. J Clin Neurophysiol 29: 356–365.
-
26.
Rathore C , Thomas B , Kesavadas C , Abraham M , Radhakrishnan K , 2013. Calcified neurocysticercosis lesions and antiepileptic drug-resistant epilepsy: a surgically remediable syndrome? Epilepsia 54: 1815–1822.
-
27.
Da Gama CN , Kobayashi E , Li LM , Cendes F , 2005. Hippocampal atrophy and neurocysticercosis calcifications. Seizure 14: 85–88.
-
28.
Wichert-Ana L et al., 2004. Surgical treatment for mesial temporal lobe epilepsy in the presence of massive calcified neurocysticercosis. Arch Neurol 61: 1117–1119.
-
29.
Mathern GW , Babb TL , Pretorius JK , Melendez M , Lévesque MF , 1995. The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron losses in temporal lobe epilepsy. Epilepsy Res 21: 133–147.
-
30.
Sloviter RS , 2008. Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the “latent period” and other concepts. Epilepsia 49: 85–92.
-
31.
Portela LVC et al., 2003. Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy: S100B and neurocysticercosis. Acta Neurol Scand 108: 424–427.
-
32.
Lima JE , Walz R , Tort A , Souza D , Portela L , Bianchin MM , Takayanagui OM , Leite JP , 2006. Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis. Braz J Med Biol Res 39: 129–135.
-
33.
Del Brutto OH , Engel J , Eliashiv DS , García HH , 2016. Update on cysticercosis epileptogenesis: the role of the hippocampus. Curr Neurol Neurosci Rep 16: 1.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1064 | 667 | 33 |
| Full Text Views | 54 | 33 | 4 |
| PDF Downloads | 63 | 37 | 4 |
Postsurgical Outcomes of Mesial Temporal Lobe Epilepsy due to Hippocampal Sclerosis Associated with Calcified Neurocysticercosis
Walter De la Cruz
Walter De la Cruz
Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Sofía S. Sánchez-Boluarte
Sofía S. Sánchez-Boluarte
Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
School of Medicine, Universidad Cesar Vallejo, Trujillo, Peru;
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School of Medicine, Universidad Cesar Vallejo, Trujillo, Peru;
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Denisse E. Chacón
Denisse E. Chacón
Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Manuel Herrera
Manuel Herrera
Department of Medicine, McMaster University, Hamilton, Ontario, Canada;
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Liza Núñez del Prado
Liza Núñez del Prado
Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Carlos M. Vásquez
Carlos M. Vásquez
Neurosurgery Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru
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José C. Delgado
José C. Delgado
Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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ABSTRACT.
The aim of this study was to analyze postsurgical outcomes for individuals with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) who underwent anterior temporal lobectomy, based on the presence of calcified neurocysticercosis (cNCC). A retrospective cross-sectional study was conducted on 89 patients with MTLE-HS who underwent anterior temporal lobectomy between January 2012 and December 2020 at a basic epilepsy surgery center located in Lima, Peru. We collected sociodemographic, clinical, and diagnostic information. The postsurgical results were analyzed using bivariate analysis according to the Engel classification. We included 89 individuals with a median age of 28 years (interquartile range [IQR]: 24–37), and more than half (55.1%) were male. Seventeen (19.1%) were diagnosed with cNCC. A greater number of patients with cNCC had lived in rural areas of Peru during their early life compared with those without cNCC (12 [70.6%] versus 26 [36.1%]; P = 0.010). Patients with cNCC exhibited a greater median frequency of focal to bilateral tonic-clonic seizures per month (1 [IQR: 0–2] versus 0 [0–0.5]; P = 0.009). Conversely, a lower proportion of patients with cNCC reported a history of an initial precipitating injury in comparison to the group without cNCC (4 [23.5%] versus 42 [58.3%]; P = 0.014). At the 1-year follow-up, most patients (82.4%) with cNCC were categorized as Engel IA. Similarly, at the 2-year follow-up, nine (75.0%) were classified as Engel IA. Our findings suggest that most patients diagnosed with cNCC exhibit favorable postsurgical outcomes, comparable to those without cNCC. Additionally, it can be postulated that cNCC may play a role as an initial precipitating injury.
Author Notes
Authors’ addresses: Walter De la Cruz, Denisse E. Chacón, Liza Núñez del Prado, and José C. Delgado, Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mails: wdelacruz1711@gmail.com, denissees@hotmail.com, sangedolma@gmail.com, and jdelgador@unmsm.edu.pe. Sofía S. Sánchez-Boluarte, Epilepsy Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, and School of Medicine, Universidad Cesar Vallejo, Trujillo, Peru, E-mail: sssboluarte@gmail.com. Manuel Herrera, Department of Medicine, McMaster University, Hamilton, Ontario, Canada, E-mail: herrem4@mcmaster.ca. Carlos M. Vásquez, Neurosurgery Department, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: carlomao79@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Engel J , 2001. Mesial temporal lobe epilepsy: what have we learned? Neuroscientist 7: 340–352.
-
2.
Wieser H-G , 2004. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 45: 20.
-
3.
Jobst BC , Cascino GD , 2015. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA 313: 285.
-
4.
Josephson CB , Dykeman J , Fiest KM , Liu X , Sadler RM , Jette N , Wiebe S , 2013. Systematic review and meta-analysis of standard vs selective temporal lobe epilepsy surgery. Neurology 80: 1669–1676.
-
5.
Velasco TR , 2006. Calcified cysticercotic lesions and intractable epilepsy: a cross sectional study of 512 patients. J Neurol Neurosurg Psychiatry 77: 485–488.
-
6.
Singla M , Singh P , Kaushal S , Bansal R , Singh G , 2007. Hippocampal sclerosis in association with neurocysticercosis. Epileptic Disord 9: 8.
-
7.
Secchi TL , Brondani R , Bragatti JA , Bizzi JWJ , Bianchin MM , 2022. Evaluating the association of calcified neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis in a large cohort of patients with epilepsy. Front Neurol 12: 769356.
-
8.
Sánchez SS et al., 2022. Hippocampal atrophy/sclerosis is associated with old, calcified parenchymal brain neurocysticercosis, but not with more recent, viable infections. Am J Trop Med Hyg 106: 215–218.
-
9.
Gupta RK , Awasthi R , Rathore RK , Verma A , Sahoo P , Paliwal VK , Prasad KN , Pandey CM , Narayana PA , 2012. Understanding epileptogenesis in calcified neurocysticercosis with perfusion MRI. Neurology 78: 618–625.
-
10.
Debacq G , Moyano LM , Garcia HH , Boumediene F , Marin B , Ngoungou EB , Preux PM , 2017. Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. PLoS Negl Trop Dis 11: e0005153.
-
11.
Montano SM et al., 2005. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology 65: 229–233.
-
12.
Rajshekhar V , Raghava MV , Prabhakaran V , Oommen A , Muliyil J , 2006. Active epilepsy as an index of burden of neurocysticercosis in Vellore district, India. Neurology 67: 2135–2139.
-
13.
Del Brutto OH , Arroyo G , Del Brutto VJ , Zambrano M , García HH , 2017. On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: a large‐scale, computed tomography–based population study in rural Ecuador. Epilepsia 58: 1955–1961.
-
14.
Nash TE , Pretell EJ , Lescano AG , Bustos JA , Gilman RH , Gonzalez AE , Garcia HH ; Cysticercosis Working Group in Peru , 2008. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case–control study. Lancet Neurol 7: 1099–1105.
-
15.
Kwan P , Arzimanoglou A , Berg AT , Brodie MJ , Allen Hauser W , Mathern G , Moshé SL , Perucca E , Wiebe S , French J , 2009. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies: definition of drug resistant epilepsy. Epilepsia 51: 1069–1077.
-
16.
Blümcke I et al., 2013. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia 54: 1315–1329.
-
17.
Blumcke I et al., 2017. Histopathological findings in brain tissue obtained during epilepsy surgery. N Engl J Med 377: 1648–1656.
-
18.
Engel J Jr., Van NP, Rasmussen TB, Ojemann LM, 1993. Outcome with respect to epileptic seizures. Engel J Jr., ed. Surgical Treatment of the Epilepsies. 2nd ed. New York: Raven Press, 609–621
-
19.
Del Brutto OH , 2020. Twenty-five years of evolution of standard diagnostic criteria for neurocysticercosis. How have they impacted diagnosis and patient outcomes? Expert Rev Neurother 20: 147–155.
-
20.
Bianchin MM , Velasco TR , Wichert-Ana L , dos Santos AC , Sakamoto AC , 2017. Understanding the association of neurocysticercosis and mesial temporal lobe epilepsy and its impact on the surgical treatment of patients with drug-resistant epilepsy. Epilepsy Behav 76: 168–177.
-
21.
De Oliveira Taveira M , Morita ME , Yasuda CL , Coan AC , Secolin R , Luiz Cunha da Costa A , Cendes F , 2015. Neurocysticercotic calcifications and hippocampal sclerosis: a case-control study. PLoS One 10: e0131180.
-
22.
Oliveira MCB , Martin MGM , Tsunemi MH , Vieira G , Castro LHM , 2014. Small calcified lesions suggestive of neurocysticercosis are associated with mesial temporal sclerosis. Arq Neuropsiquiatr 72: 510–516.
-
23.
Meguins LC , Adry RA , Silva Júnior SC , Pereira CU , Oliveira JG , Morais DF , Araújo Filho GM , Marques LH , 2015. Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis. Arq Neuropsiquiatr 73: 1014–1018.
-
24.
Chandra PS , Bal C , Garg A , Gaikwad S , Prasad K , Sharma BS , Sarkar C , Singh MB , Padma VM , Tripathi M , 2010. Surgery for medically intractable epilepsy due to postinfectious etiologies: Epilepsy Surgery for Postinfectious Etiologies. Epilepsia 51: 1097–1100.
-
25.
Tatum WO , 2012. Mesial temporal lobe epilepsy. J Clin Neurophysiol 29: 356–365.
-
26.
Rathore C , Thomas B , Kesavadas C , Abraham M , Radhakrishnan K , 2013. Calcified neurocysticercosis lesions and antiepileptic drug-resistant epilepsy: a surgically remediable syndrome? Epilepsia 54: 1815–1822.
-
27.
Da Gama CN , Kobayashi E , Li LM , Cendes F , 2005. Hippocampal atrophy and neurocysticercosis calcifications. Seizure 14: 85–88.
-
28.
Wichert-Ana L et al., 2004. Surgical treatment for mesial temporal lobe epilepsy in the presence of massive calcified neurocysticercosis. Arch Neurol 61: 1117–1119.
-
29.
Mathern GW , Babb TL , Pretorius JK , Melendez M , Lévesque MF , 1995. The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron losses in temporal lobe epilepsy. Epilepsy Res 21: 133–147.
-
30.
Sloviter RS , 2008. Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the “latent period” and other concepts. Epilepsia 49: 85–92.
-
31.
Portela LVC et al., 2003. Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy: S100B and neurocysticercosis. Acta Neurol Scand 108: 424–427.
-
32.
Lima JE , Walz R , Tort A , Souza D , Portela L , Bianchin MM , Takayanagui OM , Leite JP , 2006. Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis. Braz J Med Biol Res 39: 129–135.
-
33.
Del Brutto OH , Engel J , Eliashiv DS , García HH , 2016. Update on cysticercosis epileptogenesis: the role of the hippocampus. Curr Neurol Neurosci Rep 16: 1.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1064 | 667 | 33 |
| Full Text Views | 54 | 33 | 4 |
| PDF Downloads | 63 | 37 | 4 |