Case Report: Type 2 Leprosy Reaction Mimicking Sweet Syndrome: A Case Report and Literature Review

Chengbei Bao Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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Qiuyun Xu Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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Ying Zou Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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Zhixun Xiao Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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Bo Cheng Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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Ting Gong Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Central Laboratory, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

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Chao Ji Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;
Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;
Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

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ABSTRACT.

Type 2 leprosy reaction is a type of acute inflammation that predominantly affects borderline lepromatous leprosy and lepromatous leprosy patients and occurs before, during, or after therapy. The atypical variant, which resembles Sweet syndrome, could easily lead to misdiagnosis. Here, we report a case of a 52-year-old man who presented with type 2 leprosy reaction that mimicked Sweet syndrome. In addition, we review published cases and summarize their features to raise awareness of this atypical variant to enable improved diagnosis and management.

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Author Notes

Disclosure: Written informed consent was obtained from the individual for the publication of any potentially identifiable images or data included in this article. All datasets generated for this study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.

Authors’ addresses: Chengbei Bao, Qiuyun Xu, Ying Zou, Zhixun Xiao, and Bo Cheng, Department of Dermatology, Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, Fujian Dermatology and Venereology Research Institute, First Affiliated Hospital of Fujian Medical University, Fujian, China, E-mails: bcb_4better@fjmu.edu.cn, xqy220@fjmu.edu.cn, zouying0819@fjmu.edu.cn, zhixun@fjmu.edu.cn, and chengbo630415@126.com. Ting Gong, Department of Dermatology, Central Laboratory, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, E-mail: gongtingfy@fjmu.edu.cn.

Address correspondence to Chao Ji, Department of Dermatology, First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian 350000, China. E-mail: jichaofy@fjmu.edu.cn
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