Case Report: Gastrointestinal Basidiobolomycosis in a Young Girl with Cystic Fibrosis and Celiac Disease

Ali Tadayon Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

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Omid Reza Azh Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

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Mostafa Poor Khosravani Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

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Seyedeh Sedigheh Hamzavi Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

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Fatemeh Yarmahmoodi Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

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Babak Shirazi Yeganeh Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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Mehdi Ghasemian School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

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ABSTRACT.

Basidiobolomycosis is an uncommon fungal infection that has been reported in the literature mainly as a cause of infection in the skin and subcutaneous tissue. Intraabdominal infections have been reported in tropical and subtropical areas in the Middle East, such as Iran and Saudi Arabia, and in the United States. Our patient was a 6-year-old girl with cystic fibrosis and celiac disease who was referred to our department with a history of chronic abdominal pain. In the imaging studies of the abdomen and pelvis, a large retroperitoneal mass was reported in the right upper part of the abdomen with involvement of the duodenum and the mesentery of the small and large intestines, as well as the superior mesenteric vessels, and was diagnosed as basidiobolomycosis through biopsy. Because of the large unresectable mass, the patient was first treated with antifungal drugs for 2 months and then surgical resection was performed. The main point in the management of these patients is a combination of antifungal therapy and surgical resection. In some patients, complex surgeries such as the Whipple procedure may be performed to appropriately manage intraabdominal infections.

Author Notes

Authors’ addresses: Ali Tadayon, Omid Reza Azh, and Mostafa Poor Khosravani, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, E-mails: alitad4@gmail.com, dromidazh@gmail.com, and prkmostafa@gmail.com. Mehdi Ghasemian, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: ghasemian.m97@gmail.com. Seyedeh Sedigheh Hamzavi, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, and Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: s.hamzavi55@yahoo.com. Fatemeh Yarmahmoodi, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, and Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: yarmahmoodif@gmail.com. Babak Shirazi Yeganeh, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: babakshirazi51@gmail.com.

Address correspondence to Mehdi Ghasemian, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. E-mail: ghasemian.m97@gmail.com
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