Authors:
, , , , , , , , , , , , , , , , , and
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1.
LoVerde PT , 2019. Schistosomiasis. Adv Exp Med Biol 1154: 45–70.
-
2.
World Health Organization , 2020. Schistosomiasis. Available at: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis. Accessed November 6, 2023.
-
3.
Kayange NM , Smart LR , Tallman JE , Chu EY , Fitzgerald DW , Pain KJ , Peck RN , 2015. Kidney disease among children in sub-Saharan Africa: systematic review. Pediatr Res 77: 272–281.
-
4.
Colley DG , Bustinduy AL , Secor WE , King CH , 2014. Human schistosomiasis. Lancet 383: 2253–2264.
-
5.
Lalaye D , de Bruijn ME , de Jong TP , 2019. Prevalence of Schistosoma haematobium measured by a mobile health system in an unexplored endemic region in the subprefecture of Torrock, Chad. JMIR Public Health Surveill 5: e13359.
-
6.
Lalaye D , de Bruijn ME , de Jong TPVM , 2021. Impact of a mobile health system on the suppression of Schistosoma haematobium in Chad. Am J Trop Med Hyg 105: 1104–1108.
-
7.
Bastos MG , Karine A , Novaes B , 2018. Traditional and ultrasound physical examinations: a hybrid approach to improve clinical care. Rev Assoc Med Bras 64: 474–480.
-
8.
Trinkler F , Dietrich CF , 2020. Ultrasound of the urinary bladder. Dietrich CF, ed. EFSUMB Coursebook on Ultrasound. London, United Kingdom: European Federation of Societies for Ultrasound in Medicine and Biology, 1–41.
-
9.
Ramarakoto CE , Leutscher PDC , van Dam G , Christensen NO , 2008. Ultrasonographical findings in the urogenital organs in women and men infected with Schistosoma haematobium in northern Madagascar. Trans R Soc Trop Med Hyg 102: 767–773.
-
10.
Stamatiou K , Papadoliopoulos I , Dahanis S , Zafiropoulos G , Polizois K , 2009. The accuracy of ultrasonography in the diagnosis of superficial bladder tumors in patients presenting with hematuria. Ann Saudi Med 29: 134–137.
-
11.
Elmadani AE , Hamdoun AO , Monis A , Karamino NE , Gasmelseed N , 2013. Ultrasound findings in urinary urogenital schistosomiasisistosomaisis infection in school children in the Gezira state central Sudan. Saudi J Kidney Dis Transpl 24: 162–167.
-
12.
Dy GW , Ellison JS , Fu BC , Holt SK , Gore JL , Merguerian PA , 2017. Variable resource utilization in the prenatal and postnatal management of isolated hydronephrosis. Urology 108: 155–160.
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Assessing the Effects of One-Time Praziquantel Treatment on Urogenital Lesions Detected by Ultrasound in Schistosoma haematobium–Infected Individuals in Chad
Didier Lalaye
Didier Lalaye
Julius Global Health Center, University Medical Center Utrecht, The Netherlands;
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Tom P. V. M. de Jong
Tom P. V. M. de Jong
Department of Urology, University Children’s Hospitals UMC Utrecht, Utrecht, The Netherlands;
Department of Urology, Amsterdam UMC, Amsterdam, The Netherlands
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Department of Urology, Amsterdam UMC, Amsterdam, The Netherlands
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ABSTRACT.
The objective was to determine the impact of a single dose of praziquantel on urogenital lesions caused by Schistosoma haematobium. Ultrasound (US) was performed on three age groups of subjects with a positive test for hematuria, with the first examination performed in November 2017 and a follow-up visit 7 months later. None of the subjects had previously received treatment. The participants were categorized into three distinct age groups: group 1 = 1–15 years, group 2 = 15–30 years, and group 3 = ≥ 30 years. A total of 250 people from these three groups underwent screening: 99 in group 1, 90 in group 2, and 61 in group 3, among whom 131 (52.4%) had at least one detectable lesion of the urogenital tract on US. Follow-up US after 7 months was possible in 60%, 67%, and 77% of the respective groups (with lesions). The anomalies disappeared in 80% of individuals in group 1, 76% of those in group 2, and 65% in group 3. With the exception of calcifications, most visible anomalies had been resolved. The total number of anomalies is low. Severe obstructive uropathy was not detected. We can conclude that single treatment with praziquantel is able to cure visible anomalies, with the exception of calcifications. The low rate of anomalies, compared with levels in the literature, is speculated to be due to undetected death by obstructive uropathy caused by S. haematobium. This requires further investigation.
Author Notes
Disclosure: Before the start of the study, permission was granted by the health authority of Torroc (District sanitaire de Torrock). Individuals were informed in churches and mosques, and oral consent was given by all subjects or one of the parents of each participant under the age of 18 years. Written consent was not possible due to local illiteracy, but the community head was duly informed, and adult subjects and parents were adequately informed on the purpose of the study to obtain their verbal consent. Data were analyzed anonymously.
Authors’ addresses: Didier Lalaye, Julius Global Health Center, University Medical Center Utrecht, Utrecht, The Netherlands, E-mail: lalaye84@gmail.com. Tom P. V. M. de Jong, Department of Urology, University Children’s Hospitals UMC Utrecht, The Netherlands, and Department of Urology, Amsterdam UMC, Amsterdam, The Netherlands, E-mail: t.p.v.m.dejong@umcutrecht.nl.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
LoVerde PT , 2019. Schistosomiasis. Adv Exp Med Biol 1154: 45–70.
-
2.
World Health Organization , 2020. Schistosomiasis. Available at: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis. Accessed November 6, 2023.
-
3.
Kayange NM , Smart LR , Tallman JE , Chu EY , Fitzgerald DW , Pain KJ , Peck RN , 2015. Kidney disease among children in sub-Saharan Africa: systematic review. Pediatr Res 77: 272–281.
-
4.
Colley DG , Bustinduy AL , Secor WE , King CH , 2014. Human schistosomiasis. Lancet 383: 2253–2264.
-
5.
Lalaye D , de Bruijn ME , de Jong TP , 2019. Prevalence of Schistosoma haematobium measured by a mobile health system in an unexplored endemic region in the subprefecture of Torrock, Chad. JMIR Public Health Surveill 5: e13359.
-
6.
Lalaye D , de Bruijn ME , de Jong TPVM , 2021. Impact of a mobile health system on the suppression of Schistosoma haematobium in Chad. Am J Trop Med Hyg 105: 1104–1108.
-
7.
Bastos MG , Karine A , Novaes B , 2018. Traditional and ultrasound physical examinations: a hybrid approach to improve clinical care. Rev Assoc Med Bras 64: 474–480.
-
8.
Trinkler F , Dietrich CF , 2020. Ultrasound of the urinary bladder. Dietrich CF, ed. EFSUMB Coursebook on Ultrasound. London, United Kingdom: European Federation of Societies for Ultrasound in Medicine and Biology, 1–41.
-
9.
Ramarakoto CE , Leutscher PDC , van Dam G , Christensen NO , 2008. Ultrasonographical findings in the urogenital organs in women and men infected with Schistosoma haematobium in northern Madagascar. Trans R Soc Trop Med Hyg 102: 767–773.
-
10.
Stamatiou K , Papadoliopoulos I , Dahanis S , Zafiropoulos G , Polizois K , 2009. The accuracy of ultrasonography in the diagnosis of superficial bladder tumors in patients presenting with hematuria. Ann Saudi Med 29: 134–137.
-
11.
Elmadani AE , Hamdoun AO , Monis A , Karamino NE , Gasmelseed N , 2013. Ultrasound findings in urinary urogenital schistosomiasisistosomaisis infection in school children in the Gezira state central Sudan. Saudi J Kidney Dis Transpl 24: 162–167.
-
12.
Dy GW , Ellison JS , Fu BC , Holt SK , Gore JL , Merguerian PA , 2017. Variable resource utilization in the prenatal and postnatal management of isolated hydronephrosis. Urology 108: 155–160.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3625 | 1048 | 175 |
| Full Text Views | 58 | 20 | 0 |
| PDF Downloads | 85 | 42 | 0 |