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RefWorks
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Zotero
EndNote
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Gastrointestinal Manifestations of Chagas Disease: A Systematic Review with Meta-Analysis
Nayara Ragi Baldoni
Nayara Ragi Baldoni
University of Itaúna, Itaúna, Brazil;
Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil;
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Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil;
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Lea Campos de Oliveira-da Silva
Lea Campos de Oliveira-da Silva
Laboratory of Parasitology (LIM46), Clinical Hospital of São Paulo, Brazil;
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Ana Carolina Oliveira Gonçalves
Ana Carolina Oliveira Gonçalves
Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil;
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Nayara Dornela Quintino
Nayara Dornela Quintino
Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil;
Divinópolis Regional Health Superintendence/Minas Gerais State Health Secretariat (SES-MG), Belo Horizonte, Brazil;
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Divinópolis Regional Health Superintendence/Minas Gerais State Health Secretariat (SES-MG), Belo Horizonte, Brazil;
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Ariela Mota Ferreira
Ariela Mota Ferreira
State University of Montes Claros (Unimontes), Montes Claro, Brazil;
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Ana Luiza Bierrenbach
Ana Luiza Bierrenbach
Teaching and Research Institute of Sírio-Libanês Hospital, São Paulo, Brazil;
Graduate Program, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil;
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Graduate Program, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil;
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José Luiz Padilha da Silva
José Luiz Padilha da Silva
Department of Statistics, Federal University of Paraná, Curitiba, Brazil;
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Maria Carmo Pereira Nunes
Maria Carmo Pereira Nunes
Federal University of Minas Gerais, Belo Horizonte, Brazil;
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Antonio Luiz P. Ribeiro
Antonio Luiz P. Ribeiro
Federal University of Minas Gerais, Belo Horizonte, Brazil;
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Claudia Di Lorenzo Oliveira
Claudia Di Lorenzo Oliveira
Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil;
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Ester Cerdeira Sabino
Ester Cerdeira Sabino
Institute of Tropical Medicine, Faculty of Medicine, University of São Paulo, Brazil
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Clareci Silva Cardoso
Clareci Silva Cardoso
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ABSTRACT.
The aims of this study were to estimate the prevalence of gastrointestinal manifestations among individuals with positive serology for Chagas disease (ChD) and to describe the clinical gastrointestinal manifestations of the disease. A systematic review with meta-analysis was conducted based on the criteria and recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed, Scopus, Virtual Health Library, Web of Science, and Embase databases were used to search for evidence. Two reviewers independently selected eligible articles and extracted data. RStudio® software was used for the meta-analysis. For subgroup analysis, the studies were divided according to the origin of the individuals included: 1) individuals from health units were included in the health care service prevalence analysis, and 2) individuals from the general population were included in the population prevalence analysis. A total of 2,570 articles were identified, but after removal of duplicates and application of inclusion criteria, 24 articles were included and 21 were part of the meta-analysis. Most of the studies were conducted in Brazil. Radiological diagnosis was the most frequent method used to identify the gastrointestinal clinical form. The combined effect of meta-analysis studies showed a prevalence of gastrointestinal manifestations in individuals with ChD of 12% (95% CI, 8.0–17.0%). In subgroup analysis, the prevalence for studies involving health care services was 16% (95% CI, 11.0–23.0%), while the prevalence for population-based studies was 9% (95% CI, 5.0–15.0%). Megaesophagus and megacolon were the main forms of ChD presentation in the gastrointestinal form. The prevalence of gastrointestinal manifestations of ChD was 12%. Knowing the prevalence of ChD in its gastrointestinal form is an important step in planning health actions for these patients.
- Supplemental Materials (PDF 8.8652 KB)
Author Notes
Financial support: The Sami-Trop cohort study is supported by the
Authors’ addresses: Nayara Ragi Baldoni, University of Itaúna, Itaúna, Brazil, and Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil, E-mail: nrbaldoni@gamil.com. Lea Campos de Oliveira-da Silva, Laboratory of Parasitology (LIM46), Clinical Hospital of São Paulo, São Paulo, Brazil, E-mail: lea.c.oliveira@gmail.com. Ana Carolina Oliveira Gonçalves, Claudia Di Lorenzo Oliveira, and Clareci Silva Cardoso, Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil, E-mails: aco_goncalves@yahoo.com.br, claudiadlorenzo@gmail.com, and clarecicardoso@yahoo.com.br. Nayara Dornela Quintino, Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ/CNPq, Medical School, Federal University of de São João del-Rei, Divinópolis, Brazil, and Divinópolis Regional Health Superintendence/Minas Gerais State Health Secretariat (SES-MG), Belo Horizonte, Brazil, E-mail: nayaradornela@yahoo.com.br. Ariela Mota Ferreira, State University of Montes Claros (Unimontes), Montes Claro, Brazil, E-mail: arielamota@hotmail.com. Ana Luiza Bierrenbach, Teaching and Research Institute of Sírio-Libanês Hospital, São Paulo, Brazil, and Graduate Program, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil, E-mail: albierrenbach@yahoo.com.br. José Luiz Padilha da Silva, Department of Statistics, Federal University of Paraná, Curitiba, Brazil, E-mail: jlpadilha@ufpr.br. Maria Carmo Pereira Nunes and Antonia Luiz P. Ribeiro, Federal University of Minas Gerais, Belo Horizonte, Brazil, E-mails: mcarmo@waymail.com.br and tom1963br@yahoo.com.br. Ester Cerdeira Sabino, Institute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil, E-mail: sabinoec@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pérez-Molina JA , Molina I , 2018. Chagas disease. Lancet 6: 82–94.
-
2.
Nóbrega AA , Araújo WN , Vasconcelos AMN , 2014. Mortality due to Chagas disease in Brazil according to a specific cause. Am J Trop Med Hyg 91: 528–533.
-
3.
Ferreira AM , Santos LI , Sabino EC , Ribeiro ALP , Oliveira-da Silva LCd , Damasceno RF , D’Angelo MFSV , Nunes MCP , Haikal DS , 2022. Two-year death prediction models among patients with Chagas disease using machine learning-based methods. PLoS Negl Trop Dis 16: e0010356.
-
4.
Echavarría NG , Echeverría LE , Stewart M , Gallego C , Saldarriaga C , 2021. Chagas disease: chronic Chagas cardiomyopathy. Curr Probl Cardiol 46: 100507.
-
5.
Santos E , Falcão LM , 2020. Chagas cardiomyopathy and heart failure: from epidemiology to treatment. Rev Port Cardiol 39: 279–289.
-
6.
Matsuda NM , Miller SM , Evora PRB , 2009. The chronic gastrointestinal manifestations of Chagas disease. Clinics (São Paulo) 64: 1219–1224.
-
7.
Dantas RO , 2021. Management of esophageal dysphagia in Chagas disease. Dysphagia 36: 517–522.
-
8.
Henry MACA , Lerco MM , Oliveira WK , 2007. Câncer do esôfago em paciente com megaesôfago chagásico. Arq Gastroenterol 44: 151–155.
-
9.
Baldoni NRB , Quintino ND , Alves GCS , Oliveira CL , Sabino EC , Ribeiro ALP , Cardoso CS , 2021. Quality of life in patients with Chagas disease and the instrument used: an integrative review. Rev Inst Med Trop 63: e46.
-
10.
Bierrenbach AL et al., 2022. Hospitalizations due to gastrointestinal Chagas disease: national registry. PLoS Negl Trop Dis 16: e0010796.
-
11.
Page MJ et al., 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372: 1–9.
-
12.
Ouzzani M , Hammady H , Fredorowicz Z , Elmagarmid A , 2016. Rayyan – a web and mobile app for systematic reviews. Syst Rev 5: 210.
-
13.
Downs SH , Black N , 1998. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52: 377–384.
-
14.
Nascimento RS , Valente SRG , Oliveira LCM , 2002. Seroprevalence of Helicobacter pylori infection in chronic chagasic patients, and in the rural and urban population from Uberlândia, Minas Gerais, Brazil. Rev Inst Med Trop São Paulo 44: 251–254.
-
15.
Bey E , Condori MBP , Gaget O , Solano P , Revollo S , Saussine C , Brenière SF , 2019. Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation. World J Urol 37: 1395–1402.
-
16.
Lopes ER , Rocha A , Meneses ACO , Lopes MAB , Fatureto MC , Lopes GP , Chapadeiro E , 1989. Prevalência de megas em necrópsia realizadas no Triângulo Mineiro no período de 1954 a 1988. Rev Soc Bras Med Trop 22: 211–215.
-
17.
Portela LF et al., 2022. Socio-epidemiological factors and comorbidities associated with Chagas disease manifestations in two urban reference health care centres in Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg 117: 102–110.
-
18.
Pereira JB , Coura JR , 1986. Morbidade da doença de chagas. Estudo seccional em uma área endêmica, Virgem da Lapa, Minas Gerais. Rev Soc Bras Med Trop 19: 139–148.
-
19.
Pereira JB , Coura JR , 1987. Morbidade da doença de chagas em populações urbanas do Sertão da Paraíba. Rev Soc Bras Med Trop 20: 101–107.
-
20.
Castro C , Rezende JM , Camargo M , Prata A , Macêdo V , 1987. Prevalência de esofagopatia chagásica no município de Manbaí, Goiás, Brasil. Rev Soc Bras Med Trop 20: 13–17.
-
21.
Kamiji MM , Oliveira RB , 2005. O perfil dos portadores de doença de Chagas, com ênfase na forma digestiva, em hospital terciário de Ribeirão Preto, SP. Rev Soc Bras Med Trop 38: 305–309.
-
22.
Peñaranda-Carrillo R , Castro C , Rezende J , Aluízio Prata A , Macêdo V , 2006. Estudo radiológico do esôfago de chagásicos, em 25 anos do Projeto Mambaí. Rev Soc Bras Med Trop 39: 152–155.
-
23.
Bozelli CE , Araújo SM , Guilherme ALF , Gomes ML , 2006. Perfil clínico-epidemiológico de pacientes com doença de Chagas no Hospital Universitário de Maringá, Paraná, Brasil. Cad Saude Publica 22: 1027–1034.
-
24.
Almeida EA , Neto RMB , Guariento ME , Wanderley JS , Souza ML , 2007. Apresentação clínica da doença de Chagas crônica em indivíduos idosos. Rev Soc Bras Med Trop 40: 311–315.
-
25.
Alves RMA , Thomaz RP , Almeida EA , Wanderley JS , Guariento ME , 2009. Chagas’ disease and ageing: the coexistence of other chronic diseases with Chagas’ disease in elderly patients. Rev Soc Bras Med Trop 42: 622–628.
-
26.
Castro C , Hernandez EB , Rezende J , Prata A , 2010. Estudo radiológico do megacólon em área endêmica de doença de Chagas. Rev Soc Bras Med Trop 43: 562–566.
-
27.
Ozaki Y , Guariento ME , Almeida EA , 2011. Quality of life and depressive symptoms in Chagas disease patients. Qual Life Res 20: 133–138.
-
28.
Fonseca FM , Queiroz DMM , Rocha AMC , Prata A , Crema E , Rodrigues V Jr. , Ramirez LE , Oliveira AG , 2012. Seroprevalence of Helicobacter pylori infection in chagasic and nonchagasic patients from the same geographical region of Brazil. Rev Soc Bras Med Trop 45: 194–198.
-
29.
Castro C , Hernandez EB , Rezende J , Prata A , 2012. Occurrence of dolichocolon without megacolon in chronic Chagas disease patients. Rev Soc Bras Med Trop 45: 353–356.
-
30.
Pereira LS , Freitas EC , Fidalgo ASOBV , Andrade MC , Cândido DS , Silva Filho JD , Michailowsky V , Oliveira MF , Queiroz JAN , 2015. Clinical and epidemiological profile of elderly patients with Chagas disease followed between 2005-2013 by pharmaceutical care service in Ceará State, Northeastern Brazil. Rev Inst Med 57: 145–152.
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