Immunological Studies with Group B Arthropod-Borne Viruses

II. Effect of Prior Infection with Japanese Encephalitis Virus on the Viremia in Human Subjects Following Administration of 17D Yellow Fever Vaccine

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  • 1 Department of Microbiology, University of Maryland Medical School, Baltimore, Maryland
  • | 2 National Institute of Health, Tokyo, Japan


The incidence of viremia following vaccination with the 17D strain of yellow fever virus did not differ appreciably in a group of human subjects possessing prevaccination Japanese encephalitis neutralizing antibodies as a result of previous inapparent natural infection from the incidence of viremia in control groups possessing no prevaccination Group B arbor virus antibodies. There may have been a slight diminution in the level of circulating virus among the subjects with prevaccination JE neutralizing antibodies as compared with the level in the control groups; however, the number of uncontrolled factors which may have influenced these measurements precludes a firm conclusion on this matter.

Author Notes

Present address: Merck Institute for Research, West Point, Pennsylvania.