Anthelmintic Studies on Pyrvinium Pamoate (Povan) and Other Drugs in Rodents, Dogs, and Monkeys

Paul E. ThompsonResearch Division, Parke, Davis & Company, Ann Arbor, Michigan

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David E. WorleyResearch Division, Parke, Davis & Company, Ann Arbor, Michigan

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Jack E. MeisenhelderResearch Division, Parke, Davis & Company, Ann Arbor, Michigan

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Summary

Pyrvinium pamoate (Povan®) removed Syphacia obvelata and Aspiculuris tetraptera from mice when given either in the diet or as a single oral dose. S. muris in rats also was readily susceptible to pyrvinium pamoate but Nematospiroides dubius and Hymenolepis nana in mice were not. Multiple oral doses efficiently removed ascarids and hookworms in dogs but failed to remove whipworms.

The relationship of these effects to those of pyrvinium chloride is reviewed.

Natural Strongyloides infections in rhesus monkeys were used to assess the antistrongyloides activity of pyrvinium pamoate, while gentian violet, dithiazanine iodide, and pyrvinium chloride were tested as reference drugs. All substances were given orally as aqueous suspensions. Pyrvinium pamoate lacked significant effect under test conditions that permitted varying degrees of effect by the reference drugs. These limited comparisons suggested gentian violet to be the most potent of the drugs tested against simian strongyloidiasis.

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