Encephalitis on Taiwan

IV. Human Serology

San-Pin Wang United States Naval Medical Research Unit No. 2, Taipei, Taiwan

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J. Thomas Grayston United States Naval Medical Research Unit No. 2, Taipei, Taiwan

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Summary

The results of serologic tests with Japanese encephalitis virus antigen and sera from humans on Taiwan and adjacent islands are reported. Seventy-one of 72 adult sera from various parts of Taiwan showed neutralizing antibody against JE virus. Neutralizing antibody was found in 32% of 120 sera from 7-year-old children. Tests with sera from the Taipei area show an increasing percentage of neutralizing antibody in children from 1 through 12 years of age. HI antibody tests on these children's serum taken before and after the 1958 encephalitis season showed 4% with fourfold titer rises and a similar percent with falls in titer. The children with antibody rises were 4 to 10 years of age. Similar studies in the nearby Pescadore Islands showed that infection was uncommon in children and that only half of the adults tested had neutralising antibody. A limited interpretation of these results is presented.

Author Notes

Present address: Department of Preventive Medicine, University of Washington, Seattle 5, Washington.

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