Case Report: Osteomyelitis Due to Sporothrix brasiliensis in Two Immunocompetent Patients Requiring Surgical Amputation

Alexsander Moreira Siqueira Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Wendel Marcel D’Angioli Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Bárbara Lapera Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Isabella Gomes Carvalho de Souza Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Noel Löwenthal Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Júlia Rossit Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Simone de Abreu Neves Salles Dermatology Service, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil

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Ricardo Luiz Dantas Machado Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Elisabeth Martins da Silva da Rocha Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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Andréa Regina de Souza Baptista Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;

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ABSTRACT.

Sporotrichosis is the most frequent subcutaneous mycosis in Latin America. Sporothrix brasiliensis is the most virulent species, responsible for the majority of human and animal cases in Brazil. Osteomyelitis was described as a potential comorbidity of S. brasiliensis infection; however, surgical amputation resulting from an extracutaneous form is a rare outcome. In such cases, immunodeficiency and alcoholism must be investigated. We present two unusual cases of surgical amputation as a severe morbidity resulting from osteomyelitis by S. brasiliensis in immunocompetent nonalcoholic patients.

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Author Notes

Financial support: This work was supported by Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ - E-26/010.001882/2014), Rede Micologia RJ, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES Finance Code 001), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (W. M. D. and I. G. C. S. were granted PIBIC/CNPq scholarships; A. R. S. B. and R. L. D. M. are research fellows of CNPq, Brazil).

Authors’ addresses: Alexsander Moreira Siqueira, Wendel Marcel D’Angioli, Bárbara Lapera, Isabella Gomes Carvalho de Souza, Noel Löwenthal, Júlia Rossit, Ricardo Luiz Dantas Machado, Elisabeth Martins da Silva da Rocha, and Andréa Regina de Souza Baptista, Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil, E-mails: amsiqueira@id.uff.br, marcelcosta879@msn.com, barbaramlapera@gmail.com, isabella_gomes@id.uff.br, noellowenthal@id.uff.br, julia.rossit1996@gmail.com, ricardomachado@id.uff.br, martinselisabeth@id.uff.br, and andrearegina@id.uff.br. Simone de Abreu Neves Salles, Dermatology Service, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil, E-mail: reneg9233@gmail.com.

Address correspondence to Andréa Regina de Souza Baptista, Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Block E, Outeiro de São João Batista, s/n, Centro, Niterói, RJ 24020-140, Brazil. E-mail: andrearegina@id.uff.br
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