ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Freitas DF , Santos SS , Almeida-Paes R , de Oliveira MM , do Valle AC , Gutierrez-Galhardo MC , Zancopé-Oliveira RM , Nosanchuk JD , 2015. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence 6: 112–120.
-
2.
Barros NM , Pessoa AS , Brotas AM , 2020. Systemic sporotrichosis in an alcoholic patient. An Bras Dermatol 95: 376–378.
-
3.
Gandhi N , Chander R , Jain A , Sanke S , Garg T , 2016. Atypical cutaneous sporotrichosis in an immunocompetent adult: response to potassium iodide. Indian J Dermatol 61: 236.
-
4.
Hassan K , Turker T , Zangeneh T , 2016. Disseminated sporotrichosis in an immunocompetent patient. Case Reports Plast Surg Hand Surg 3: 44–47.
-
5.
Orofino-Costa R , Unterstell N , Gripp AC , Macedo PM , Brota A , Dias E , Teixeira MM , Felipe MS , Bernardes-Engemanna AR , Lopes-Bezerra LM , 2013. Pulmonary cavitation and skin lesions mimicking tuberculosis in a HIV negative patient caused by Sporothrix brasiliensis. Med Mycol Case Rep 2: 65–71.
-
6.
Monte Alves M et al., 2020. Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Negl Trop Dis 14: e0008141.
-
7.
Gremião IDF , Oliveira MME , Monteiro de Miranda LH , Saraiva Freitas DF , Pereira SA , 2020. Geographic expansion of sporotrichosis, Brazil. Emerg Infect Dis 26: 621–624.
-
8.
Hessler C , Kauffman CA , Chow FC , 2017. The upside of bias: a case of chronic meningitis due to Sporothrix schenckii in an immunocompetent host. Neurohospitalist 7: 30–34.
-
9.
Medeiros KB , Landeiro LG , Diniz LM , Falqueto A , 2016. Esporotricose disseminada cutânea associada à lesão ocular em paciente imunocompetente. An Bras Dermatol 91: 537–539.
-
10.
Lederer HT , Sullivan E , Crum-Cianflone NF , 2016. Sporotrichosis as an unusual case of osteomyelitis: a case report and review of the literature. Med Mycol Case Rep 11: 31–35.
-
11.
Ramos V et al., 2021. Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil. PLoS Negl Trop Dis 15: e0009250.
-
12.
Espinel-Ingroff A et al., 2017. Multicenter, international study of MIC/MEC distributions for definition of epidemiological cutoff values for Sporothrix species identified by molecular methods. Antimicrob Agents Chemother 61: e01057-17.
-
13.
Aronowitz PB , Gilroy M , Christiansen KN , 2017. Disseminated sporotrichosis with osteolytic bone involvement. J Gen Intern Med 32: 1063.
-
14.
Freitas DF , Valle AC , da Silva MB , Campos DP , Lyra MR , de Souza RV , Veloso VG , Zancopé-Oliveira RM , Bastos FI , Galhardo MC , 2015. Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil. PLoS Negl Trop Dis 8: e3110.
-
15.
Gladstone JI , Littman M , 1971. Osseous sporotrichosis: failure of treatment with potassium iodide and sulfadimethoxine and success with amphotericin B. Am J Med 51: 121–133.
-
16.
Kasimoğlu O , Murat A , Kotoğyan A , 1966. A localized case of sporotrichosis with osteomyelitic manifestations of Garré pattern. Tip Fak Mecm 29: 514–523.
-
17.
Sharkey-Mathis PK , Kauffman CA , Graybill JR , Stevens DA , Hostetler JS , Cloud G , Dismukes WE , 1993. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med 95: 279–285.
-
18.
Yagnik KJ , Skelton WP 4th , Olson A , Trillo CA , Lascano J , 2017. A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia. IDCases 9: 70–72.
-
19.
Ferreira LC , Barroso PF , Tonomura E , Akiti T , de Pinho Rodrigues KM , 2016. Osteomyelitis caused by Sporothrix schenckii in an immunocompetent patient. Rev Soc Bras Med Trop 49: 527–529.
-
20.
Jorge LS , Chueire AG , Rossit ARB , 2010. Osteomyelitis: a current challenge. Braz J Infect Dis 14: 310–315.
-
21.
Lew DP , Waldvogel FA , 2004. Osteomyelitis. Lancet 364: 369–379.
-
22.
Rao N , Ziran BH , Lipsky BA , 2011. Treating osteomyelitis: antibiotics and surgery. Plast Reconstr Surg 127 (Suppl 1 ):177S–187S.
-
23.
Calhoun DL , Waskin H , White MP , Bonner JR , Mulholland JH , Rumans LW , Stevens DA , Galgiani JN , 1991. Treatment of systemic sporotrichosis with ketoconazole. Rev Infect Dis 13: 47–51.
-
24.
Eustace KE , Sampaio FM , Lyra MR , Quintella L , do Valle AC , 2013. Cutaneous disseminated sporotrichosis complicated by osteomyelitis. Acta Derm Venereol 93: 192–193.
-
25.
Friedman SJ , Doyle JA , 1983. Extracutaneous sporotrichosis. Int J Dermatol 22: 171–176.
-
26.
Macêdo-Sales PA et al., 2020. Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area. Fungal Genet Biol 140: 103397.
-
27
Ministério da Saúde, Gabinete do Ministro , 2020. Diário Oficial da União, Portaria n° 264, de 17 de Fevereiro de 2020. Available at: https://www.in.gov.br/en/web/dou/-/portaria-n-264-de-17-de-fevereiro-de-2020-244043656, Accessed November 21, 2022.
-
28.
Alzuguir CLC , Pereira SA , Magalhães MAFM , Almeida-Paes R , Freitas DFS , Oliveira LFA , Pimentel MIF , 2020. Geo-epidemiology and socioeconomic aspects of human sporotrichosis in the municipality of Duque de Caxias, Rio de Janeiro, Brazil, between 2007 and 2016. Trans R Soc Trop Med Hyg 114: 99–106.
-
29.
Della Terra PP , Rodrigues AM , Fernandes GF , Nishikaku AS , Burger E , de Camargo ZP , 2017. Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis. PLoS Negl Trop Dis 11: e0005903.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2498 | 1109 | 271 |
| Full Text Views | 119 | 58 | 3 |
| PDF Downloads | 103 | 38 | 4 |
Case Report: Osteomyelitis Due to Sporothrix brasiliensis in Two Immunocompetent Patients Requiring Surgical Amputation
Alexsander Moreira Siqueira
Alexsander Moreira Siqueira
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Wendel Marcel D’Angioli
Wendel Marcel D’Angioli
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Bárbara Lapera
Bárbara Lapera
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Isabella Gomes Carvalho de Souza
Isabella Gomes Carvalho de Souza
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Noel Löwenthal
Noel Löwenthal
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Júlia Rossit
Júlia Rossit
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Simone de Abreu Neves Salles
Simone de Abreu Neves Salles
Dermatology Service, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil
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Ricardo Luiz Dantas Machado
Ricardo Luiz Dantas Machado
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Elisabeth Martins da Silva da Rocha
Elisabeth Martins da Silva da Rocha
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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Andréa Regina de Souza Baptista
Andréa Regina de Souza Baptista
Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil;
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ABSTRACT.
Sporotrichosis is the most frequent subcutaneous mycosis in Latin America. Sporothrix brasiliensis is the most virulent species, responsible for the majority of human and animal cases in Brazil. Osteomyelitis was described as a potential comorbidity of S. brasiliensis infection; however, surgical amputation resulting from an extracutaneous form is a rare outcome. In such cases, immunodeficiency and alcoholism must be investigated. We present two unusual cases of surgical amputation as a severe morbidity resulting from osteomyelitis by S. brasiliensis in immunocompetent nonalcoholic patients.
- Supplemental Materials (PDF 676.48 KB)
Author Notes
Financial support: This work was supported by
Authors’ addresses: Alexsander Moreira Siqueira, Wendel Marcel D’Angioli, Bárbara Lapera, Isabella Gomes Carvalho de Souza, Noel Löwenthal, Júlia Rossit, Ricardo Luiz Dantas Machado, Elisabeth Martins da Silva da Rocha, and Andréa Regina de Souza Baptista, Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niterói, Brazil, E-mails: amsiqueira@id.uff.br, marcelcosta879@msn.com, barbaramlapera@gmail.com, isabella_gomes@id.uff.br, noellowenthal@id.uff.br, julia.rossit1996@gmail.com, ricardomachado@id.uff.br, martinselisabeth@id.uff.br, and andrearegina@id.uff.br. Simone de Abreu Neves Salles, Dermatology Service, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil, E-mail: reneg9233@gmail.com.
ProCite
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BibTeX
Zotero
EndNote
-
1.
Freitas DF , Santos SS , Almeida-Paes R , de Oliveira MM , do Valle AC , Gutierrez-Galhardo MC , Zancopé-Oliveira RM , Nosanchuk JD , 2015. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence 6: 112–120.
-
2.
Barros NM , Pessoa AS , Brotas AM , 2020. Systemic sporotrichosis in an alcoholic patient. An Bras Dermatol 95: 376–378.
-
3.
Gandhi N , Chander R , Jain A , Sanke S , Garg T , 2016. Atypical cutaneous sporotrichosis in an immunocompetent adult: response to potassium iodide. Indian J Dermatol 61: 236.
-
4.
Hassan K , Turker T , Zangeneh T , 2016. Disseminated sporotrichosis in an immunocompetent patient. Case Reports Plast Surg Hand Surg 3: 44–47.
-
5.
Orofino-Costa R , Unterstell N , Gripp AC , Macedo PM , Brota A , Dias E , Teixeira MM , Felipe MS , Bernardes-Engemanna AR , Lopes-Bezerra LM , 2013. Pulmonary cavitation and skin lesions mimicking tuberculosis in a HIV negative patient caused by Sporothrix brasiliensis. Med Mycol Case Rep 2: 65–71.
-
6.
Monte Alves M et al., 2020. Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Negl Trop Dis 14: e0008141.
-
7.
Gremião IDF , Oliveira MME , Monteiro de Miranda LH , Saraiva Freitas DF , Pereira SA , 2020. Geographic expansion of sporotrichosis, Brazil. Emerg Infect Dis 26: 621–624.
-
8.
Hessler C , Kauffman CA , Chow FC , 2017. The upside of bias: a case of chronic meningitis due to Sporothrix schenckii in an immunocompetent host. Neurohospitalist 7: 30–34.
-
9.
Medeiros KB , Landeiro LG , Diniz LM , Falqueto A , 2016. Esporotricose disseminada cutânea associada à lesão ocular em paciente imunocompetente. An Bras Dermatol 91: 537–539.
-
10.
Lederer HT , Sullivan E , Crum-Cianflone NF , 2016. Sporotrichosis as an unusual case of osteomyelitis: a case report and review of the literature. Med Mycol Case Rep 11: 31–35.
-
11.
Ramos V et al., 2021. Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil. PLoS Negl Trop Dis 15: e0009250.
-
12.
Espinel-Ingroff A et al., 2017. Multicenter, international study of MIC/MEC distributions for definition of epidemiological cutoff values for Sporothrix species identified by molecular methods. Antimicrob Agents Chemother 61: e01057-17.
-
13.
Aronowitz PB , Gilroy M , Christiansen KN , 2017. Disseminated sporotrichosis with osteolytic bone involvement. J Gen Intern Med 32: 1063.
-
14.
Freitas DF , Valle AC , da Silva MB , Campos DP , Lyra MR , de Souza RV , Veloso VG , Zancopé-Oliveira RM , Bastos FI , Galhardo MC , 2015. Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil. PLoS Negl Trop Dis 8: e3110.
-
15.
Gladstone JI , Littman M , 1971. Osseous sporotrichosis: failure of treatment with potassium iodide and sulfadimethoxine and success with amphotericin B. Am J Med 51: 121–133.
-
16.
Kasimoğlu O , Murat A , Kotoğyan A , 1966. A localized case of sporotrichosis with osteomyelitic manifestations of Garré pattern. Tip Fak Mecm 29: 514–523.
-
17.
Sharkey-Mathis PK , Kauffman CA , Graybill JR , Stevens DA , Hostetler JS , Cloud G , Dismukes WE , 1993. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med 95: 279–285.
-
18.
Yagnik KJ , Skelton WP 4th , Olson A , Trillo CA , Lascano J , 2017. A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia. IDCases 9: 70–72.
-
19.
Ferreira LC , Barroso PF , Tonomura E , Akiti T , de Pinho Rodrigues KM , 2016. Osteomyelitis caused by Sporothrix schenckii in an immunocompetent patient. Rev Soc Bras Med Trop 49: 527–529.
-
20.
Jorge LS , Chueire AG , Rossit ARB , 2010. Osteomyelitis: a current challenge. Braz J Infect Dis 14: 310–315.
-
21.
Lew DP , Waldvogel FA , 2004. Osteomyelitis. Lancet 364: 369–379.
-
22.
Rao N , Ziran BH , Lipsky BA , 2011. Treating osteomyelitis: antibiotics and surgery. Plast Reconstr Surg 127 (Suppl 1 ):177S–187S.
-
23.
Calhoun DL , Waskin H , White MP , Bonner JR , Mulholland JH , Rumans LW , Stevens DA , Galgiani JN , 1991. Treatment of systemic sporotrichosis with ketoconazole. Rev Infect Dis 13: 47–51.
-
24.
Eustace KE , Sampaio FM , Lyra MR , Quintella L , do Valle AC , 2013. Cutaneous disseminated sporotrichosis complicated by osteomyelitis. Acta Derm Venereol 93: 192–193.
-
25.
Friedman SJ , Doyle JA , 1983. Extracutaneous sporotrichosis. Int J Dermatol 22: 171–176.
-
26.
Macêdo-Sales PA et al., 2020. Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area. Fungal Genet Biol 140: 103397.
-
27
Ministério da Saúde, Gabinete do Ministro , 2020. Diário Oficial da União, Portaria n° 264, de 17 de Fevereiro de 2020. Available at: https://www.in.gov.br/en/web/dou/-/portaria-n-264-de-17-de-fevereiro-de-2020-244043656, Accessed November 21, 2022.
-
28.
Alzuguir CLC , Pereira SA , Magalhães MAFM , Almeida-Paes R , Freitas DFS , Oliveira LFA , Pimentel MIF , 2020. Geo-epidemiology and socioeconomic aspects of human sporotrichosis in the municipality of Duque de Caxias, Rio de Janeiro, Brazil, between 2007 and 2016. Trans R Soc Trop Med Hyg 114: 99–106.
-
29.
Della Terra PP , Rodrigues AM , Fernandes GF , Nishikaku AS , Burger E , de Camargo ZP , 2017. Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis. PLoS Negl Trop Dis 11: e0005903.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2498 | 1109 | 271 |
| Full Text Views | 119 | 58 | 3 |
| PDF Downloads | 103 | 38 | 4 |